SLC11A1 antibody (AA 1-58)

Catalog No. ABIN7161089

Product Details anti-SLC11A1 Antibody

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Binding Specificity: AA 1-58

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC11A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Natural resistance-associated macrophage protein 1 protein (1-58AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:300, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLC11A1

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Alternative Name: SLC11A1 (SLC11A1 Products)

Background:

Background: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Aliases: LSH antibody, Natural resistance associated macrophage protein 1 antibody, Natural resistance-associated macrophage protein 1 antibody, NRAM1_HUMAN antibody, NRAMP 1 antibody, NRAMP antibody, PBC antibody, SLC11A1 antibody, Solute carrier family 11 (proton coupled divalent metal ion transporters) member 1 antibody, solute carrier family 11 (sodium/phosphate symporters) member 1 antibody, Solute carrier family 11 member 1 antibody

UniProt: P49279

Pathways: Transition Metal Ion Homeostasis, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus