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PSMB8 antibody (AA 176-276) (HRP)

PSMB8 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7164993
$328.90
Plus shipping costs $45.00
Shipping to: United States
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  • Target See all PSMB8 Antibodies
    PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
    Binding Specificity
    • 15
    • 9
    • 8
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 176-276
    Reactivity
    • 69
    • 8
    • 7
    • 1
    • 1
    Human
    Host
    • 57
    • 7
    • 7
    • 1
    Rabbit
    Clonality
    • 66
    • 6
    Polyclonal
    Conjugate
    • 36
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSMB8 antibody is conjugated to HRP
    Application
    • 54
    • 35
    • 30
    • 17
    • 14
    • 14
    • 12
    • 8
    • 7
    • 7
    • 3
    • 3
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Proteasome subunit beta type-8 protein (176-276AA)
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
    Alternative Name
    PSMB8 (PSMB8 Products)
    Synonyms
    ALDD antibody, D6S216 antibody, D6S216E antibody, JMP antibody, LMP7 antibody, NKJO antibody, PSMB5i antibody, RING10 antibody, ATP6V0D2 antibody, lmp7 antibody, prosome antibody, macropain antibody, Lmp-7 antibody, Lmp7 antibody, Ring10 antibody, proteasome subunit beta 8 antibody, proteasome subunit beta 8A antibody, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) antibody, PSMB8 antibody, psmb8a antibody, Psmb8 antibody
    Background

    Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.

    Aliases: ALDD antibody, D6S216 antibody, D6S216E antibody, Large multifunctional peptidase 7 antibody, Large multifunctional protease 7 antibody, LMP 7 antibody, LMP7 antibody, Low molecular mass protein 7 antibody, Low molecular weight protein 7 antibody, Macropain subunit C13 antibody, MGC1491 antibody, Multicatalytic endopeptidase complex subunit C13 antibody, NKJO antibody, OTTHUMP00000062981 antibody, Protease component C13 antibody, Proteasome (prosome macropain) subunit beta type 8 antibody, Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) antibody, Proteasome beta 8 subunit antibody, Proteasome catalytic subunit 3i antibody, Proteasome component C13 antibody, Proteasome related gene 7 antibody, Proteasome subunit beta 5i antibody, Proteasome subunit beta 8 antibody, Proteasome subunit beta type 8 antibody, Proteasome subunit beta type antibody, Proteasome subunit beta type-8 antibody, Proteasome subunit beta-5i antibody, Proteasome subunit Y2 antibody, PSB8_HUMAN antibody, PSMB 8 antibody, PSMB5i antibody, PSMB8 antibody, Really interesting new gene 10 protein antibody, RING 10 antibody, RING10 antibody, Y2 antibody

    UniProt
    P28062
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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