SGK3 antibody (AA 1-150)

Catalog No. ABIN7169180

Product Details anti-SGK3 Antibody

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Binding Specificity: AA 1-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGK3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase Sgk3 protein (1-150AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SGK3

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Alternative Name: SGK3 (SGK3 Products)

Background:

Background: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.

Aliases: CISK antibody, Cytokine independent survival kinase antibody, DKFZp781N0293 antibody, Serine/threonine protein kinase Sgk3 antibody, Serine/threonine-protein kinase Sgk3 antibody, Serum/glucocorticoid regulated kinase 3 antibody, Serum/glucocorticoid regulated kinase family member 3 antibody, Serum/glucocorticoid regulated kinase like antibody, Serum/glucocorticoid-regulated kinase 3 antibody, Serum/glucocorticoid-regulated kinase-like antibody, SGK 2 antibody, SGK 3 antibody, SGK2 antibody, Sgk3 antibody, SGK3_HUMAN antibody, SGKL antibody

UniProt: Q96BR1