SMG6 antibody (AA 251-511) (HRP)

Catalog No. ABIN7171720

Product Details anti-SMG6 Antibody (HRP)

Target: SMG6 (Smg-6 Homolog, Nonsense Mediated mRNA Decay Factor (SMG6))

Binding Specificity: AA 251-511

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMG6 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Telomerase-binding protein EST1A protein (251-511AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMG6

Target: SMG6 (Smg-6 Homolog, Nonsense Mediated mRNA Decay Factor (SMG6))

Alternative Name: SMG6 (SMG6 Products)

Background:

Background: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5\'-(GTGTGG)(4)GTGT-3\' telomeric DNA, but not to a telomerase RNA template component (TER).

Aliases: SMG6 antibody, C17orf31 antibody, EST1A antibody, KIAA0732Telomerase-binding protein EST1A antibody, EC 3.1.-.- antibody, EST1-like protein A antibody, Ever shorter telomeres 1A antibody, Smg-6 homolog antibody, Telomerase subunit EST1A antibody, hSmg5/7a antibody

UniProt: Q86US8