TGFBR2 antibody (AA 25-159)

Catalog No. ABIN7171961

Product Details anti-TGFBR2 Antibody

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Binding Specificity: AA 25-159

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TGF-beta receptor type-2 protein (25-159AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TGFBR2

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Alternative Name: TGFBR2 (TGFBR2 Products)

Background:

Background: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Aliases: AAT3 antibody, FAA3 antibody, LDS1B antibody, LDS2 antibody, LDS2B antibody, MFS2 antibody, RIIC antibody, TAAD2 antibody, TbetaR II antibody, TbetaR-II antibody, TGF beta receptor type 2 antibody, TGF beta receptor type II antibody, TGF beta receptor type IIB antibody, TGF beta type II receptor antibody, TGF-beta receptor type II antibody, TGF-beta receptor type-2 antibody, TGF-beta type II receptor antibody, TGF-beta-R2 antibody, TGFB R2 antibody, TGFbeta - RII antibody, TGFbeta RII antibody, Tgfbr2 antibody, TGFR-2 antibody, TGFR2_HUMAN antibody, Transforming growth factor beta receptor II antibody, Transforming growth factor beta receptor type II antibody, Transforming growth factor beta receptor type IIC antibody, Transforming growth factor, beta receptor II (70/80 kDa) antibody, transforming growth factor, beta receptor II alpha antibody, transforming growth factor, beta receptor II beta antibody, transforming growth factor, beta receptor II delta antibody, transforming growth factor, beta receptor II epsilon antibody, transforming growth factor, beta receptor II gamma antibody, Transforming growth factor-beta receptor type II antibody

UniProt: P37173