TRPV4 antibody (AA 1-230)

Catalog No. ABIN7172887

Product Details anti-TRPV4 Antibody

Target: TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))

Binding Specificity: AA 1-230

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPV4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Transient receptor potential cation channel subfamily V member 4 protein (1-230AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRPV4

Target: TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))

Alternative Name: TRPV4 (TRPV4 Products)

Background:

Background: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH , citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca2+ in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Aliases: BCYM3 antibody, CMT2C antibody, HMSN2C antibody, osm 9 like TRP channel 4 antibody, Osm-9-like TRP channel 4 antibody, OSM9 like transient receptor potential channel 4 antibody, Osmosensitive transient receptor potential channel 4 antibody, OTRPC 4 antibody, OTRPC4 antibody, SMAL antibody, SPSMA antibody, SSQTL1 antibody, Transient receptor potential cation channel subfamily V member 4 antibody, Transient receptor potential protein 12 antibody, TRP 12 antibody, TRP12 antibody, TRPV 4 antibody, TrpV4 antibody, TRPV4_HUMAN antibody, Vanilloid receptor like channel 2 antibody, Vanilloid receptor like protein 2 antibody, Vanilloid receptor related osmotically activated channel antibody, Vanilloid receptor-like channel 2 antibody, Vanilloid receptor-like protein 2 antibody, Vanilloid receptor-related osmotically-activated channel antibody, VR 4 antibody, VR OAC antibody, VR-OAC antibody, VR4 antibody, VRL 2 antibody, VRL-2 antibody, VRL2 antibody, VROAC antibody

UniProt: Q9HBA0

Pathways: Hormone Transport, Cell-Cell Junction Organization