PTPRF antibody (AA 1104-1163)
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- Target See all PTPRF Antibodies
- PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))
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Binding Specificity
- AA 1104-1163
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PTPRF antibody is un-conjugated
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Application
- ELISA, Flow Cytometry (FACS)
- Purpose
- PTPRF Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human PTPRF (AA: 1104-1163) expressed in E. Coli.
- Clone
- 6D7C7
- Isotype
- IgG1
- Top Product
- Discover our top product PTPRF Primary Antibody
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))
- Alternative Name
- PTPRF (PTPRF Products)
- Background
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Description:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Aliases: LAR, BNAH2
- Molecular Weight
- 213kDa
- Gene ID
- 5792
- Pathways
- EGFR Signaling Pathway
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