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ZNF451 antibody

ZNF451 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7384122
  • Target See all ZNF451 Antibodies
    ZNF451 (Zinc Finger Protein 451 (ZNF451))
    Reactivity
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 19
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    This ZNF451 antibody is un-conjugated
    Application
    • 19
    • 12
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human ZNF451 (NP_001026794.1).
    Isotype
    IgG
    Top Product
    Discover our top product ZNF451 Primary Antibody
  • Application Notes
    WB 1:200-1:2000
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ZNF451 (Zinc Finger Protein 451 (ZNF451))
    Alternative Name
    ZNF451 (ZNF451 Products)
    Synonyms
    COASTER antibody, dJ417I1.1 antibody, 4930515K21Rik antibody, 4933435G09Rik antibody, AI596398 antibody, Kiaa0576-hp antibody, Znf451 antibody, mKIAA1702 antibody, zinc finger protein 451 antibody, ZNF451 antibody, Zfp451 antibody
    Background
    ZNF451,COASTER,dJ417I1.1,E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
    Molecular Weight

    Observed_MW: Refer to figures

    Calculated_MW: 63 kDa/115 kDa/121 kDa

    Gene ID
    26036
    UniProt
    Q9Y4E5
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