ZNF451 antibody
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- Target See all ZNF451 Antibodies
- ZNF451 (Zinc Finger Protein 451 (ZNF451))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ZNF451 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human ZNF451 (NP_001026794.1).
- Isotype
- IgG
- Top Product
- Discover our top product ZNF451 Primary Antibody
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- Application Notes
- WB 1:200-1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- ZNF451 (Zinc Finger Protein 451 (ZNF451))
- Alternative Name
- ZNF451 (ZNF451 Products)
- Synonyms
- COASTER antibody, dJ417I1.1 antibody, 4930515K21Rik antibody, 4933435G09Rik antibody, AI596398 antibody, Kiaa0576-hp antibody, Znf451 antibody, mKIAA1702 antibody, zinc finger protein 451 antibody, ZNF451 antibody, Zfp451 antibody
- Background
- ZNF451,COASTER,dJ417I1.1,E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
- Molecular Weight
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Observed_MW: Refer to figures
Calculated_MW: 63 kDa/115 kDa/121 kDa
- Gene ID
- 26036
- UniProt
- Q9Y4E5
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