BTLA antibody
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- Target See all BTLA Antibodies
- BTLA (B and T Lymphocyte Associated (BTLA))
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Reactivity
- Human, Non-Human Primate
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BTLA antibody is un-conjugated
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Application
- Flow Cytometry (FACS)
- Purpose
- Anti-Hu CD272 Purified
- Specificity
- The mouse monoclonal antibody MIH26 recognizes an extracellular epitope of CD272, a transmembrane glycoprotein serving as a negative regulator of the activation in various leukocyte types.
- Purification
- Purified by protein-A affinity chromatography.
- Immunogen
- cells transfected with human CD272
- Clone
- MIH26
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product BTLA Primary Antibody
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- Application Notes
- Flow cytometry: Recommended dilution: 2-5 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- BTLA (B and T Lymphocyte Associated (BTLA))
- Alternative Name
- CD272 (BTLA Products)
- Background
- B and T lymphocyte associated,CD272, a type I transmembrane glycoprotein, contains in its intracellular domain two ITIM sequences, which are upon CD272 triggering phosphorylated and recruit SHP phosphatases to attenuate cell activation. CD272 is expressed on B and T lymphocytes, NK cells, dendritic cells, and macrophages, and its ligand is CD270. Defects in CD272-CD270 inhibitory mechanism lead to autoimmune diseases. Overexpression of CD272 is a marker of tolerant T cells.,BTLA1
- Gene ID
- 151888
- UniProt
- Q7Z6A9
- Pathways
- Cancer Immune Checkpoints
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