CD172a/b antibody (PerCP,Cy5.5)

Catalog No. ABIN7566611

Product Details

Target: CD172a/b

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: PerCP,Cy5.5

Application: Flow Cytometry (FACS)

Purpose: PerCP/Cyanine5.5 Anti-Human CD172a/b Antibody[SE5A5]

Clone: SE5A5

Isotype: IgG1, kappa

Application Details

Application Notes: Each lot of this antibody is quality control tested by flow cytometric analysis. Applications vary, the appropriate dilutions must be determined for individual use.
FCM: 5 µL/test

Comment:

Matching Isotype Control: abo_E-AB-F09792J

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Expiry Date: 12 months

Target Details

Target: CD172a/b

Background: SIRPa,SIRPb,SIRPalpha/beta,BIT,SHPS1,MFR,P84,PTPNS1,CD172 antigen-like family member A,CD172 antigen-like family member B,CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.

Gene ID: 140885

UniProt: O00241