beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 451-501) antibody

Details for Product No. ABIN725705
Antigen
  • ASP2
  • BACE
  • HSPC104
  • C76936
  • Bace
  • MGC145931
  • BACE1
  • zgc:77409
  • beta-secretase 1
  • beta-site APP cleaving enzyme 1
  • beta-site APP-cleaving enzyme 1
  • BACE1
  • Bace1
  • bace1
Epitope
AA 451-501
39
23
17
14
9
7
4
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
209
112
85
8
8
6
6
6
6
6
5
4
4
3
1
1
1
Host
Rabbit
198
20
5
Clonality
Polyclonal
Conjugate
Un-conjugated
7
6
4
4
4
4
4
4
4
3
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
134
87
64
40
25
17
16
14
10
8
5
3
2
2
1
Options
Immunogen KLH conjugated synthetic peptide derived from human BACE1
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name BACE1 (BACE Antibody Abstract)
Background

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Subcellular location: Cytoplasm

Synonyms: ASP2, BACE, HSPC104, Beta-secretase 1, Aspartyl protease 2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, KIAA1149

Gene ID 23621
UniProt P56817
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 451-501) antibody (ABIN725705) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Po...
Image no. 2 for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 451-501) antibody (ABIN725705) L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (A...
Image no. 3 for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 451-501) antibody (ABIN725705) Mouse muscle lysates probed with Rabbit Anti-BACE1 Polyclonal Antibody, Unconjugated ...
Product cited in: Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, 2018 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: brain

Hong, Shen, Yin, Sun, Ma, Liu: "Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus." in: Neurochemical research, Vol. 41, Issue 5, pp. 1192-9, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Brain

Yan, Yun, Ku, Li, Sang: "NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication." in: Scientific reports, Vol. 6, pp. 22429, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: Brain

Jiao, Kong, Yao, Li, Tao, Yan, Yang: "Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease." in: Neuropharmacology, Vol. 108, pp. 332-44, 2016 (PubMed). Method employed by authors: Immunohistochemistry (Frozen Sections) (IHC (fro)) (Sample species: Mouse (Murine)). Further details: Sample: Brain

Tian, Guo, Wu, Ma, Zhao: "Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats." in: Cellular and molecular neurobiology, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Brain

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