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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) (AA 301-390) antibody (Biotin) Primary Antibody

KCNJ11 Reactivity: Human, Mouse, Rat ELISA, IHC (p), WB Host: Rabbit Polyclonal Biotin
Catalog No. ABIN740252
$419.10
Plus shipping costs $45.00
100 μL
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  • Target
    Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11)
    Binding Specificity
    • 23
    • 17
    • 16
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-390
    Reactivity
    • 97
    • 55
    • 27
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 90
    • 7
    • 1
    Rabbit
    Clonality
    • 98
    Polyclonal
    Conjugate
    • 29
    • 9
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Biotin
    Application
    • 65
    • 54
    • 26
    • 23
    • 16
    • 14
    • 9
    • 9
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Cross-Reactivity
    Cow, Dog, Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Kir62
    Isotype
    IgG
  • Application Notes
    WB 1:300-1000
    ELISA 1:500-1000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C
    Expiry Date
    12 months
  • Target
    Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11)
    Alternative Name
    Kir6.2 (KCNJ11) (KCNJ11 Antibody Abstract)
    Synonyms
    kir6.2, Kir6.2, mBIR, BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3, potassium voltage-gated channel subfamily J member 11, potassium inwardly-rectifying channel, subfamily J, member 11, potassium inwardly rectifying channel, subfamily J, member 11, KCNJ11, kcnj11, Kcnj11
    Background

    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

    Subcellular location: Cell membrane

    Synonyms: ATP sensitive inward rectier potassium channel 11, Beta cell inward rectier subunit, mBIR, BIR, HHF 2, HHF2, IKATP, Inward rectier K+ channel Kir6.2, Inwardly rectying potassium channel KIR6.2, IRK 11, IRK11, KCNJ11, Kir 6.2, Kir6.2, MGC133230, PHHI, Potassium channel, inwardly rectying subfamily J member 11, Potassium inwardly rectying channel J11, TNDM 3, TNDM3, IRK11_HUMAN.

    Gene ID
    3767
    UniProt
    Q14654
    Pathways
    Negative Regulation of Hormone Secretion
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