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Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) (AA 701-800) antibody (Alexa Fluor 647) Primary Antibody

INPPL1 Reactivity: Mouse, Rat IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 647
Catalog No. ABIN902767
$442.20
Plus shipping costs $45.00
100 μL
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Delivery in 11 to 16 Business Days
  • Target
    Inositol Polyphosphate Phosphatase-Like 1 (INPPL1)
    Binding Specificity
    • 16
    • 16
    • 15
    • 14
    • 8
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 701-800
    Reactivity
    • 64
    • 57
    • 41
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 75
    • 3
    • 1
    Rabbit
    Clonality
    • 77
    • 2
    Polyclonal
    Conjugate
    • 24
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Alexa Fluor 647
    Application
    • 38
    • 38
    • 26
    • 19
    • 16
    • 9
    • 9
    • 4
    • 3
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Cow, Dog, Horse, Human, Pig, Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human INPPL1
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 4 °C
    Expiry Date
    12 months
  • Target
    Inositol Polyphosphate Phosphatase-Like 1 (INPPL1)
    Alternative Name
    INPPL1 (INPPL1 Antibody Abstract)
    Synonyms
    inppl1, si:bz46j2.7, si:rp71-46j2.7, INPPL1, OPSMD, SHIP2, 51C, Ship2, inositol polyphosphate phosphatase-like 1b, inositol polyphosphate phosphatase like 1, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B, inositol polyphosphate phosphatase-like 1, inppl1b, INPPL1, LOC100180571, Inppl1
    Background

    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity.

    Subcellular location: Cytoplasm, Cell membrane

    Synonyms: OPSMD, SHIP2, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Inositol polyphosphate phosphatase-like protein 1, INPPL-1, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol phosphatase 2, SHIP-2, INPPL1

    Gene ID
    3636
    UniProt
    O15357
    Pathways
    Platelet-derived growth Factor Receptor Signaling
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