ACD antibody (C-Term)

Catalog No. ABIN927647

Product Details anti-ACD Antibody

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Binding Specificity: C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACD antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: Acd antibody was raised in rabbit using the c terminal of Acd as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

Acd Blocking Peptide, catalog no. 33R-7345, is also available for use as a blocking control in assays to test for specificity of this Acd antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for ACD

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Alternative Name: Acd (ACD Products)

Synonyms: PIP1 antibody, PTOP antibody, TINT1 antibody, TPP1 antibody, ACD antibody, ACD, shelterin complex subunit and telomerase recruitment factor antibody, adrenocortical dysplasia antibody, ACD antibody, Acd antibody

Background: Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo. Synonyms: Polyclonal Acd antibody, Anti-Acd antibody, adrenocortical dysplasia antibody.

Pathways: Telomere Maintenance