CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5)

Details for Product anti-CD40 Antibody No. ABIN94104
Antigen
Reactivity
Human
466
235
70
16
16
9
9
6
4
3
3
2
2
2
1
1
Host
Mouse
321
186
131
12
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD40 antibody is un-conjugated
66
66
39
26
10
9
8
5
5
4
4
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
381
198
159
107
78
55
52
47
35
14
13
12
5
4
3
3
2
2
2
1
1
1
1
1
1
1
Options
Immunogen Human CD40a
Clone HI40a
Isotype IgG1
Specificity The antibody HI40a recognizes CD40 (BP50), a 48 kDa type I single chain transmembrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells. CD40 antigen is also present on Hodgkin's and Reed-Sternberg cells, follicular dendritic cells, some macrophages, basal epithelial cells and endothelial cells.
Cross-Reactivity (Details) Human
Purification Purified by protein-A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Sterility 0.2 μm filtered
Antigen
Alternative Name CD40 (CD40 Antibody Abstract)
Background CD40 is a costimulatory molecule of the TNF receptor superfamily and is expressed on many cell types, such as B cells, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts or vascular smooth muscle cells. Interaction of CD40 and its ligand CD154 (CD40L) is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. In monocytes/macrophages CD40 engagement induces production of pro-inflammatory cytokines and chemokines. CD40-CD154 interactions are also critical for development of CD4 T cell-dependent effector functions. CD40 links innate and adaptive immune responses to bacterial stimuli and serves as an important regulator affecting functions of other costimulatory molecules.
Pathways NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μ,m filter sterilized.
Preservative Azide free
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Supplier Images
Image no. 1 for anti-CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) antibody (ABIN94104) Surface staining of human peripheral blood cells with anti-human CD40 (HI40a) FITC. C...