Thyroid Stimulating Hormone (TSH) antibody

Details for Product No. ABIN94482
Antigen
Reactivity
Human
284
27
20
6
4
1
Host
Mouse
216
47
30
5
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
24
16
15
14
14
14
2
2
2
2
2
2
1
1
1
1
1
1
Application
Radioimmunoassay (RIA), ELISA
211
32
31
25
17
13
13
11
10
8
6
6
6
4
3
3
3
2
2
1
1
1
1
1
Options
Immunogen Human thyrotropin.
Clone TSH-116
Isotype IgG2a
Specificity The antibody TSH-116 reacts with human thyroid stimulating hormone (hTSH, thyrotropin), a glycoprotein hormone produced by the anterior pituitary gland cells in response to signals from the hypothalamus gland in the brain.
The TSH-116 reacts with association constant 1.1 x 1011 l/mol.
Following cross-reactivity expressed as binding of labelled hormone (% of total) was determined by solid phase RIA with excess of the antibody TSH-116: hTSH (78.9), hCG (20.3), hLH (23.2), hFSH (29.9).
Cross-Reactivity (Details) Human
Purification Purified by protein-A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Antigen
Alternative Name Thyrotropin (hTSH)
Background Thyrotropin (hTSH) promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones. hTSH is composed of two subunits - alpha nad beta.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Jirkalová, Cáp, Straková, Príbysová, Plicka, Lomský: "Immunoradiometric and luminescence immunoenzymometric assay of human thyrotropin from dried blood spots for screening of neonatal hypothyroidism." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 10, pp. 823-7, 1997 (PubMed).