MBTPS2 antibody (N-Term)

Catalog No. ABIN953342

Product Details anti-MBTPS2 Antibody

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Binding Specificity: AA 14-44, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human MBTPS2 (N-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human MBTPS2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MBTPS2

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Alternative Name: MBTPS2 (MBTPS2 Products)

Background: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.Synonyms: Membrane-bound transcription factor site-2 protease, S2P, S2P endopeptidas, Site-2 protease, Sterol regulatory element-binding proteins intramembrane protease

Molecular Weight: 57444 Da

Gene ID: 51360

NCBI Accession: NP_056968

Pathways: ER-Nucleus Signaling