Influenza A Matrix Protein 2 antibody (Influenza A Virus) (N-Term)

Catalog No. ABIN966508

Product Details

Target: Influenza A Matrix Protein 2 (M2)

Binding Specificity: N-Term

Reactivity: Influenza A Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of influenza A virus Matrix protein M2

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details

Target: Influenza A Matrix Protein 2 (M2)

Abstract: M2 Products

Target Type: Influenza Protein

Background: The Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell's nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans-Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans-Golgi network, from incorrect maturation in an otherwise low pH environment