s100b antibody (S100 Calcium Binding Protein B)

Details for Product anti-S100B Antibody No. ABIN966987
Antigen
  • NEF
  • S100
  • S100-B
  • S100beta
  • S100P
  • AI850290
  • Bpb
  • si:dkey-110p14.2
  • wu:fq18b10
  • zgc:92776
  • S100 calcium binding protein B
  • S100 protein, beta polypeptide, neural
  • S100 calcium binding protein, beta (neural)
  • S100B
  • S100b
  • s100b
Reactivity
Human
372
247
219
171
40
25
8
7
4
2
2
1
1
1
Host
Mouse
211
201
11
4
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This s100b antibody is un-conjugated
38
27
14
9
9
9
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
3
3
3
3
3
3
3
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
343
186
163
159
113
63
59
28
25
22
16
14
9
8
3
3
2
2
1
1
1
1
Options
Immunogen Purified recombinant fragment of S100B expressed in E. Coli.
Clone 9A11B9
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others s100b products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name S100B (S100B Antibody Abstract)
Background S100B (S100 calcium binding protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S100B are present in a variety of other tissues, and calbindin is present in intestine and kidney. Parvalbumin B is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Synonyms: NEF, S100, S100beta
Gene ID 6285
Pathways Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Zimmer, Chaplin, Baldwin, Rast: "S100-mediated signal transduction in the nervous system and neurological diseases." in: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 51, Issue 2, pp. 201-14, 2005 (PubMed).

Shapiro, Marks, Whitaker-Azmitia: "Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome." in: Brain research, Vol. 1010, Issue 1-2, pp. 17-21, 2004 (PubMed).

Product cited in: Sorci, Riuzzi, Arcuri, Giambanco, Donato: "Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4880-94, 2004 (PubMed).

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