MMP 9 antibody

Catalog No. ABIN969288

Product Details anti-MMP 9 Antibody

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP 9 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: MMP9 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MMP9 expressed in E. Coli.

Clone: 5G3

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MMP 9 antibody (ABIN969288)

Bozzi, Inzitari, Sbardell, Monaco, Pavoni, Gioia, Marini, Morlacchi, Sciandra, Castagnola, Giardina, Brancaccio, Coletta: "Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site." in: IUBMB life, Vol. 61, Issue 12, pp. 1143-52, (2009) (PubMed).

Lipari, Mauro, Tortorici, Burruano, Leone, Spatola, Gerbino, Buscemi, Teté: "Immunohistochemical and transcriptional expression of the matrix metalloproteinases MMP-2 and MMP-9 in normal and pathological human oral mucosa." in: Journal of biological regulators and homeostatic agents, Vol. 23, Issue 4, pp. 259-67, (2009) (PubMed).

Target Details for MMP 9

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Alternative Name: MMP9 (MMP9 Products)

Background:

Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Aliases: GELB, CLG4B, MMP-9, MANDP2

Molecular Weight: 92kDa

Gene ID: 4318

HGNC: 4318

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events