SLC22A1 antibody

Catalog No. ABIN969400

Product Details anti-SLC22A1 Antibody

Target: SLC22A1 (Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SLC22A1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: SLC22A1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human SLC22A1 expressed in E. Coli.

Clone: 2C5

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-SLC22A1 antibody (ABIN969400)

Zach, Krieger, Foedermayr, Zellhofer, Lutz: "OCT1 (SLC22A1) R61C polymorphism and response to imatinib treatment in chronic myeloid leukemia patients." in: Leukemia & lymphoma, Vol. 49, Issue 11, pp. 2222-3, (2008) (PubMed).

Hirayama, Watanabe, Nakashima, Nanbu, Hamada, Kuniyasu, Nakayama, Kawaguchi, Saito: "Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells." in: Pharmaceutical research, Vol. 25, Issue 4, pp. 827-35, (2008) (PubMed).

Giannoudis, Davies, Lucas, Harris, Pirmohamed, Clark: "Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia." in: Blood, Vol. 112, Issue 8, pp. 3348-54, (2008) (PubMed).

Target Details for SLC22A1

Target: SLC22A1 (Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))

Alternative Name: SLC22A1 (SLC22A1 Products)

Background:

Description: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Tissue specificity: Widely expressed with high level in liver.

Aliases: OCT1, HOCT1, oct1_cds, SLC22A1

Molecular Weight: 61.2kDa

Gene ID: 6580

HGNC: 6580

UniProt: O15245

Pathways: Hormone Transport