Class II, Major Histocompatibility Complex, Transactivator (CIITA) (AA 1) antibody

Details for Product No. ABIN97339
Antigen
Epitope
AA 1
16
4
3
2
2
1
1
1
1
1
Reactivity
Pig (Porcine)
43
30
28
5
2
2
1
1
1
1
Host
Rabbit
43
3
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
Application
Western Blotting (WB)
38
24
7
7
5
4
2
1
1
Options
Immunogen The immunogen used for this study was a bacterially produced recombinant FLAG-CIITA corresponding to through 333 of the human protein.
Immunogentype:Recombinant
Characteristics Concentration Definition: by Refractometry
Antigen
Alternative Name CIITA (CIITA Antibody Abstract)
Background Anti-CIITA antibody detects CIITA. The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
Synonyms: MHC class II transactivator CIITA MHC2TA
Gene ID 4261
UniProt P33076
Pathways Cancer Immune Checkpoints
Application Notes For immunoblotting a 1:500 dilution is recommended. Researchers should determine optimal titers for other applications.
Restrictions For Research Use only
Format Liquid
Concentration 90 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Class II, Major Histocompatibility Complex, Transactivator (CIITA) (AA 1) antibody (ABIN97339) Western blot of Anti-CIITA antibody, generated by immunization with bacterially prod...
Product cited in: Scharer, Choi, Barwick, Majumder, Lohsen, Boss: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." in: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, 2015 (PubMed).

Koues, Dudley, Mehta, Greer: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, 2009 (PubMed).