Fibrinogen antibody

Details for Product anti-Fibrinogen Antibody No. ABIN99207
Antigen
Reactivity
Human
242
85
57
33
28
25
16
2
1
1
1
Host
Goat
165
120
92
61
10
3
Clonality
Polyclonal
Conjugate
This Fibrinogen antibody is un-conjugated
44
42
40
4
4
4
4
4
3
3
3
3
3
3
3
3
3
1
Application
ELISA
260
199
68
51
50
50
42
40
38
31
28
27
20
19
16
9
8
6
5
4
3
2
2
1
1
1
1
1
1
1
1
1
1
Options
Immunogen Fibrinogen [Human Plasma]
Immunogentype:Native
Isotype IgG
Characteristics Concentration Definition: by UV absorbance at 280 nm
Antigen
Background Fibrinogen (factor I) is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for converting fibrinogen into fibrin. Fibrin is then cross linked by factor XIII to form a clot. FXIIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha-2-antiplasmin and TAFI (thrombin activatable fibrinolysis inhibitor, procarboxypeptidase B), and binding to several adhesive proteins of various cells. Both the activation of Factor XIII by thrombin and plasminogen activator (t-PA) are catalyzed by fibrin. Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps them in the network of fibers, thus functioning as a temporary inhibitor of these enzymes, which stay active and can be released during fibrinolysis. Recent research has shown that fibrin plays a key role in the inflammatory response. Anti-Fibrinogen (Human Plasma) is ideal for Serum Protein Component research.
Synonyms: FGA antibody, FGA protein antibody, FGB antibody, FGG antibody, Fib2 antibody, Fibrinogen A alpha polypeptide antibody, Fibrinogen A alpha polypeptide chain antibody, Fibrinogen alpha chain antibody
Gene ID 2243
UniProt P02671
Application Notes Anti-FIBRINOGEN has been assayed against 1.0 µg of Fibrinogen [Human Plasma] in a standard sandwich ELISA using Peroxidase conjugated Affinity Purified anti-Goat IgG [H&L] Rabbit) (ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid]) as a substrate for 30 minutes at room temperature.  A working dilution of 1:10,000 to 1:50,000 of the reconstitution concentration is suggested for this product. Specific conditions for reactivity should be optimized by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with deionized water (or equivalent)
Concentration 10.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Image no. 1 for anti-Fibrinogen antibody (ABIN99207) Immunohistochemistry of Goat Anti-Fibrinogen antibody. Tissue: human liver tissue. Fi...
Image no. 2 for anti-Fibrinogen antibody (ABIN99207) anti-Fibrinogen antibody (Image 2)