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The role of BAK1 in defense against root-knot nematode and pattern-triggered immunity
N-glycosylation and specific ERQC components are essential to activate bak1/serk4 cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated cell death.
BAK1 and SOBIR1 associate with each other in planta when the function of BIR1 (show KCNJ6 Proteins) is compromised.
an allosteric mechanism for inhibition of BAK1 by C408 S-glutathionylation
Study identifies a link between plant perception of biotic threats by BAK1, cellular calcium entry mediated by GLRs, and intracellular calcium release by TPC1 (show TPCN1 Proteins) during a biologically relevant interaction.
The Arabidopsis Malectin (show MLEC Proteins)-Like/LRR-RLK (show TXK Proteins) IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity
These findings show that BAK1 contains an additional AtRALF1 binding site, indicating that this protein may be part of a AtRALF1-containing complex as a co-receptor, and it is required for the negative regulation of cell expansion
the existence of partial redundancy between SERK3 and SERK1 as well as the promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways, is reported.
The found that in an otherwise "active" BAK1 the alphaC helix is highly disordered, a hallmark of deactivation, whereas the BRI1 alphaC helix is moderately disordered and displays swinging behavior similar to numerous animal kinases.
These data suggest that BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death.
interleukin-6 (show IL6 Proteins), endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bak mRNA was significantly increased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
This comprehensive survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core is highly structured, and the C-termini are flexible but restrained by their contact with the membrane.
The BAK1/BCL2 (show BCL2 Proteins) ratio was positively correlated with the results of audiometric tests. Our results indicate that BAK-mediated apoptosis may be a core mechanism in the progression of age-related hearing impairment in humans
UMI-77 enhances TRAIL-induced apoptosis by unsequestering Bim (show BCL2L11 Proteins) and Bak, which provides a novel therapeutic strategy for the treatment of gliomas.
after the induction of apoptosis, Bak switches from its association with Mtx2 (show MTX2 Proteins) and VDAC2 (show VDAC2 Proteins) to a closer association with Mtx1 (show MTX1 Proteins).
Conversion of Bim (show BCL2L11 Proteins)-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
The results strongly suggest that the direct apoptosis-activation activities of Bid (show BID Proteins), Bim (show BCL2L11 Proteins), Puma (show BBC3 Proteins), and p53 (show TP53 Proteins) are not essential for activating Bax (show BAX Proteins)/Bak once the anti-apoptotic Bcl-2 (show BCL2 Proteins) proteins are neutralized.
Studied BAK1, SPRY4 (show SPRY4 Proteins) and GAB2 (show GAB2 Proteins) SNPs in pediatric germ cell tumors(GCT (show QPCT Proteins)); found a variant in SPRY4 (show SPRY4 Proteins) was associated with reduced risk of GCT (show QPCT Proteins); a variant in BAK1 was positively associated with GCT (show QPCT Proteins) with a strong estimated effect for testis tumors; and a SNP in GAB2 (show GAB2 Proteins) was associated with increased risk for GCT (show QPCT Proteins).
These results not only establish Bok (show BOK Proteins) as a Bak- and Bax (show BAX Proteins)-independent apoptosis inducer, but also suggest a potential impact of Bok (show BOK Proteins) expression in ovarian cancer therapy.
The low-level constitutive production of platelets caused by the G allele of rs5745568 in BAK1 protein seems to increase the risk of bleeding in dengue infection
the expression of Bak1 was downregulated in CRC (show CALR Proteins) tumor tissues and was reversely correlated with the expression of miR410, which provided further support that Bak1 was regulated by miR410.
We propose that the GC-induced mitochondrial accumulation of Bax (show BAX Proteins) and the interaction between the GR and Bim (show BCL2L11 Proteins), Bcl-xL (show BCL2L1 Proteins) and Bak could play a role in the regulation of thymocyte apoptosis.
Postnatal synaptic rearrangement needed for acquisition of skilled behaviors requires the activity-dependent, non-apoptotic Bax (show BAX Proteins)/Bak-caspase (show CASP3 Proteins) signaling cascade. Adult Bax (show BAX Proteins)/Bak mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors.
The authors show that Bak is activated and that activated Bak is bound to p53 (show TP53 Proteins) during reovirus encephalitis.
Pancreatic beta-Cell Death due to Pdx-1 (show PDX1 Proteins) Deficiency Requires Multi-BH Domain Protein Bax (show BAX Proteins) but Not Bak.
lipid profile in the absence of the proapoptotic proteins BAX (show BAX Proteins) and BAK in mouse embryonic fibroblasts
alpha1 dissociation is a key step in unfolding Bak into three major components, the N terminus, the core (alpha2-alpha5) and the latch (alpha6-alpha8) that is required for apoptosis.
BAX (show BAX Proteins) and BAK have a nonapoptotic role in eicosanoid metabolism in inflammation.
Puma (show BBC3 Proteins) is the major mediator of virus-induced Bax (show BAX Proteins)/Bak activation and mitochondrial membrane permeabilization induction.
Motifs of VDAC2 (show VDAC2 Proteins) required for mitochondrial Bak import and tBid-induced apoptosis.
regulation of A1 and Bak contribute to mitochondrial membrane stability, reduced caspase-9 (show CASP9 Proteins) activity, and delayed apoptosis in bovine neutrophils exposed to glucocorticoids
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
BCL2-like 7 protein
, apoptosis regulator BAK
, bcl-2 homologous antagonist/killer
, bcl-2-like protein 7
, pro-apoptotic protein BAK
, Bcl2 homologous antagonist/killer
, Bcl-2-like 7