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anti-Human BIRC3 Antibodies:
anti-Mouse (Murine) BIRC3 Antibodies:
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Human Monoclonal BIRC3 Primary Antibody for IP, WB - ABIN967367
Deveraux, Reed: IAP family proteins--suppressors of apoptosis. in Genes & development 1999
Show all 6 Pubmed References
Human Monoclonal BIRC3 Primary Antibody for IP, WB - ABIN967366
Goyal: Cell death inhibition: keeping caspases in check. in Cell 2001
Show all 7 Pubmed References
Human Polyclonal BIRC3 Primary Antibody for ICC, IF - ABIN4298725
Almubarak, Jones, Chaisuparat, Zhang, Meiller, Scheper: Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers. in Journal of carcinogenesis 2011
Show all 3 Pubmed References
Human Polyclonal BIRC3 Primary Antibody for ICC, IF - ABIN439961
Guicciardi, Mott, Bronk, Kurita, Fingas, Gores: Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in Experimental cell research 2010
Show all 2 Pubmed References
Human Polyclonal BIRC3 Primary Antibody for IHC (p), WB - ABIN390069
Wang, Wang, Evers: Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. in The Journal of biological chemistry 2003
Show all 7 Pubmed References
Rat (Rattus) Polyclonal BIRC3 Primary Antibody for ELISA, WB - ABIN4298723
Zheng, Kabaleeswaran, Wang, Cheng, Wu: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. in Molecular cell 2010
Human Polyclonal BIRC3 Primary Antibody for IHC, IHC (fro) - ABIN4298718
Schuster, Malinowsky, Liebmann, Berg, Wolff, Tran, Schott, Reu, Neumann, Faber, Höfler, Kirchner, Becker, Hlubek: Antibody validation by combining immunohistochemistry and protein extraction from formalin-fixed paraffin-embedded tissues. in Histopathology 2012
Human Polyclonal BIRC3 Primary Antibody for IHC (fro), IHC (p) - ABIN252132
Jo, Park, Cha, Ahn, Kim, Kim, Koo, Jeong, Park, Dong, Lee: Cellular inhibitor of apoptosis protein 2 promotes the epithelial-mesenchymal transition in triple-negative breast cancer cells through activation of the AKT signaling pathway. in Oncotarget 1970
Human Polyclonal BIRC3 Primary Antibody for IHC (p), IHC - ABIN5563850
Shen, Esnault, Schinzel, Borner, Malter: The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. in Nature immunology 2009
NAIP (show NAIP Antibodies) expression is most abundant in M2 macrophages, while cIAP1 (show BIRC2 Antibodies) and cIAP2 show an inverse pattern of expression in polarized cells, cIAP2 is preferentially expressed in M1-macrophages and cIAP1 (show BIRC2 Antibodies) in M2-macrophages. IAP (show ALPI Antibodies) antagonist treatment of resting M0 macrophages preceding polarization stimulation, induced upregulation of NAIP (show NAIP Antibodies) in M2 and downregulation of cIAP1 (show BIRC2 Antibodies) in M1 and M2 but an induction of cIAP2 in M1 macrophages.
Results indicate that Pellino-1 (show PELI1 Antibodies) contributes to lung oncogenesis through the overexpression of inhibitor of apoptosis protein 2 (cIAP2) and promotion of cell survival and chemoresistance.
We show that BIRC3 has a unique role in facilitating glioma progression from low- to high-grade
CIAP2 expression was elevated in human GBC tissues.
destabilization of TRAF2 (show TRAF2 Antibodies) by miR-17 reduced the ability of TRAF2 (show TRAF2 Antibodies) to associate with cIAP2, resulting in the downregulation of TNF-alpha (show TNF Antibodies)-induced NF-kappaBp65, c-Jun (show JUN Antibodies), and STAT3 (show STAT3 Antibodies) nuclear translocation and the production of IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), MMP-1 (show MMP1 Antibodies), and MMP-13 (show MMP13 Antibodies) in human rheumatoid arthritis synovial fibroblasts.
The expression of cIAP2 mRNA was significantly higher in the groups with Helicobacter pylori(+), atrophic gastritis/intestinal metaplasia(+), and Helicobacter pylori-positive early gastric cancer than in the control, Helicobacter pylori(+), and atrophic gastritis/intestinal metaplasia(-) groups.
Polymorphisms in the BIRC3 gene are associated with a protective effect with regards to asthma susceptibility, and a reduced load of inflammatory cells.
we indicated that miR (show MLXIP Antibodies)-34a can inhibit tumor invasion and metastasis in osteosarcoma, and its mechanism may be partly related to downregulating the expression of C-IAP2 and Bcl-2 (show BCL2 Antibodies) protein directly or indirectly.
Study demonstrate that BIRC3 expression increases secondary to acquisition of temozolomide TMZ and irradiation resistance in glioblastoma.
High BIRC3 expression is associated with pancreatic cancer.
These data reveal how, upon XIAP (show XIAP Antibodies) deficiency, a TLR-TNF (show TNF Antibodies)-TNFR2 (show TNFRSF1B Antibodies) axis drives cIAP1 (show BIRC2 Antibodies)-TRAF2 (show TRAF2 Antibodies) degradation to allow TLR or TNFR1 (show TNFRSF1A Antibodies) activation of RIPK3 (show RIPK3 Antibodies)-caspase-8 (show CASP8 Antibodies) and IL-1beta (show IL1B Antibodies). This mechanism may explain why XIAP (show XIAP Antibodies)-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations.
These results reveal an additional level of regulation of the stability and the activity of E2F1 (show E2F1 Antibodies) by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase (show MUL1 Antibodies) cIAP1 (show BIRC2 Antibodies).
Drugs targeting XIAP (show XIAP Antibodies) and cIAP1 (show BIRC2 Antibodies)/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 (show RIPK1 Antibodies) and contain high levels of TNFalpha (show TNF Antibodies).
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Antibodies) signaling by suppressing Pellino 1 (show PELI1 Antibodies)-mediated K63-linked ubiquitination of cIAP2, K48-linked ubiquitination, and degradation of TRAF3 (show TRAF3 Antibodies).
Birc3-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer.
c-IAP (show ALPI Antibodies) ubiquitin protein ligase (show UBE2K Antibodies) activity is required for 4-1BB (show TNFRSF9 Antibodies) signaling and CD8 (show CD8A Antibodies)(+) memory T-cell survival.
Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit.
we show that cIAP1 (show BIRC2 Antibodies) regulates TNF (show TNF Antibodies)-induced actin cytoskeleton reorganization through a cdc42 (show CDC42 Antibodies)-dependentpathway
cIAP2 (Birc3)-dependent antagonism of RIPK3 (show RIPK3 Antibodies)-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis.
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
IAP homolog C
, RING finger protein 49
, TNFR2-TRAF signaling complex protein
, TNFR2-TRAF-signaling complex protein 1
, apoptosis inhibitor 2
, baculoviral IAP repeat-containing 3
, baculoviral IAP repeat-containing protein 3
, inhibitor of apoptosis protein 1
, mammalian IAP homolog C
, apoptosis inhibitor 1
, baculoviral IAP repeat-containing 2
, baculoviral IAP repeat-containing protein 3-like
, inhibitor of apoptosis protein-2