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Adhesive properties of the leukocyte integrin Mac-1 are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 modulates inflammatory gene expression in macrophages.
Bone marrow mesenchymal stromal cells induce the rapid differentiation of CD11b+ myeloid cells from bone marrow progenitors, and such an activity requires the expression of nitric oxide synthase-2.
Mac-1(-/-) pups have reduced numbers of type I alveolar cells, respiratory failure and low survival.
data provide evidence that the NLRC4 (show NLRC4 Proteins) inflammasome contributes to resistance through regulation of caspase-1 (show CASP1 Proteins), IL-1beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) in a CD11blowLy6Glow population of cells
CD11b+Gr-1 (show GSR Proteins)+ myeloid-derived suppressor cells suppress T cells in an IFN-gamma (show IFNG Proteins)- and nitric oxide-dependent manner to reduce atherosclerotic lesion development in LDLr (show LDLR Proteins) deficient mice.
Mesenteric lymph node CD11b(-) CD103 (show ITGAE Proteins)(+) PD-L1 (show CD274 Proteins)(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (show TGFB1 Proteins) activation.
TLR-stimulated macrophages from CD11B SNP carriers showed increased basal expression of IFN regulatory factor 7 (IRF7 (show IRF7 Proteins)) and IFN-beta (show IFNB1 Proteins), as well as increased nuclear exclusion of FOXO3 (show FOXO3 Proteins), which was suppressed by LA1-dependent activation of CD11b.
The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (show SIGLEC1 Proteins) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (show YWHAZ Proteins) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling
a novel role for CR3 and microglia in brain Abeta (show APP Proteins) metabolism and defining a potential new therapeutic target in Alzheimer disease.
Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4 (show TIMD4 Proteins)) on a proportion of CD103 (show ITGAE Proteins)+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).
This study shown the ITGAM expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.
CD11b expression on polymorphonuclear leukocytes from patients with ankylosing spondylitis stimulated with lipopolysaccharide is not different to that of healthy controls.
The use of CD33 (show CD33 Proteins)(+)CD11b(+)HLA-DR(-) cells as a predictive and prognostic biomarker.
demonstrate for the first time a dependency of monocyte-platelet aggregates and CD11b expression on monocytes in the presence of atrial fibrillation (AF) and support the notion of a close relationship between AF, thrombogenesis and inflammation
Increased CD11b+ and CD200 (show CD200 Proteins)+ monocytes in those with a strong presence of BVN indicate that BVN development may be associated with retinal injury and a VEGF (show VEGFA Proteins)-mediated process that is either reflected or propelled by systemic changes in monocytes.
This study, we provide evidence supporting a crucial pathogenic role for alphaM-integrin (CD11b) in acute inflammatory demyelinating polyradiculoneuropathy mononuclear leukocyte trafficking.
FRbeta (show FOLR2 Proteins) as a novel CD11b/CD18 regulator for trafficking and homing of a subset of macrophages on collagen.
this study shows that upregulation of CD11b after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults
These data describe the presence of specific pattern recognition receptor transcripts in the mRNA isolated from bovine neutrophil and show a CD11b-/Ca(2 (show CA2 Proteins)+) dependent ROS (show ROS1 Proteins) production
The molecular cloning and characterization of CD11b from cattle and its similarities to other species are presented.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
MAC-1 alpha subunit
, integrin alpha M
, integrin alpha-M
, CD11 antigen-like family member B
, CD11B (p170)
, CR-3 alpha chain
, Mac-1 alpha
, cell surface glycoprotein MAC-1 alpha subunit
, cell surface glycoprotein MAC-1 subunit alpha
, complement component receptor 3 alpha-a
, complement receptor type 3
, leukocyte adhesion receptor MO1
, macrophage antigen alpha
, antigen CD11b (p170)
, macrophage antigen alpha polypeptide
, neutrophil adherence receptor alpha-M subunit
, leukocyte integrin alpha-M chain
, complement receptor 3
, leukocyte integrin alpha M