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Human Clusterin Protein expressed in Mammalian Cells - ABIN1691610
Son, Diamond, Volpe, Aranow, Mackay, Santiago-Schwarz: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. in Scientific reports 2017
Human Clusterin Protein expressed in Escherichia coli (E. coli) - ABIN1344142
Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages. in Journal of leukocyte biology 2011
Zebrafish clusterin is expressed in the notochord and nervous system during development. Clusterin has also role in neuronal cell death and thus, more generally, in neurodegeneration.
Data show that inhibition or targeted knockdown of Notch (show NOTCH1 Proteins) signaling significantly increased clusterin mRNA expression in choroid plexus.
Downregulation of apoE (show APOE Proteins) and apoJ in CSF (show CSF2 Proteins) strongly suggests a critical role of lipid metabolism in the development and progression of Moyamoya disease.
Using global proteomic profiling of brain leptomeningeal arteries, this study revealed that clusterin and tissue inhibitor of metalloproteinases-3 (show TIMP3 Proteins) increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.
The presence of microbial invasion of the amniotic cavity, intra-amniotic inflammation (IAI), and microbial-associated IAI was characterized by lower amniotic fluid clusterin concentrations in pregnancies complicated by preterm prelabor rupture of membranes.
Our meta-analysis demonstrated that the rs9331888/C> G polymorphism in the clusterin gene might contribute to Alzheimer disease susceptibility especially in Caucasian populations.
these findings revealed that CLU genotypes could probably modulate the cerebral the Abeta (show APP Proteins) loads on imaging and volume of hippocampus
No association for CLU with Alzheimer's disease in south-Indian population.
we confirm that a PEX (show PHEX Proteins)/Alzheimer's Disease associated risk variant, rs2279590, resides within an enhancer element and regulates the expression of three candidate genes CLU, PTK2B (show PTK2B Proteins) and EPHX2 (show EPHX2 Proteins), which were previously known to be modulators in the progression of Alzheimer's Disease.
Silencing the expression of CLU could improve the anticancer efficacy of CPT (show CHPT1 Proteins).
Thus, we suggest that a combination of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) inhibitors with V-ATPase (show ATP6V1H Proteins) inhibitors might be an effective approach for NSCLC treatment.
plasma clusterin was associated with lower volume of the entorhinal cortex, an area that atrophies early in AD. Clusterin could be informative as part of a multi-component preclinical marker for AD
Results of quantitative real-time polymerase chain reaction analysis showed that Clu mRNA levels in the inner ear were increased during embryogenesis and were constantly expressed in the adult.
Exposure of primary hippocampal neurons to Abeta42 induced an overexpression of intracellular clusterin, but the level of clusterin in supernatants did not change. Moreover, in APP (show APP Proteins)/PSEN1 (show PSEN1 Proteins) mice, there was a significant increase in intracellular clusterin in cortex and hippocampus, compared to age-matched wild-type (WT) mice, while serum clusterin level in APP (show APP Proteins)/PSEN1 (show PSEN1 Proteins) mice and in WT mice has no significant difference.
These findings suggest that in the absence of CLU, Abeta (show APP Proteins) clearance shifts to perivascular drainage pathways, resulting in fewer parenchymal plaques but more CAA because of loss of CLU chaperone activity, complicating the potential therapeutic targeting of CLU for AD.
Sustained expression of clusterin in liver functioned as a preconditioning stimulus and prevented methionine and choline deficient (MCD (show MLYCD Proteins)) diet-induced severe steatohepatitis injury via Nrf2 (show NFE2L2 Proteins) activation.
Clusterin deficiency worsens renal inflammation and tissue fibrosis after ischemia-reperfusion injury in the kidney.
The results identify Clusterin as a new molecular partner involved in apoptotic cell efferocytosis and suggest a protective role for Clusterin in inflammation and autoimmune diseases.
Both CLU and PLXNA4 (show PLXNA4 Proteins) have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 (show PLXNA4 Proteins) or targeting CLU-PLXNA4 (show PLXNA4 Proteins) interactions may have therapeutic value in AD.
clusterin-induced TNF-alpha (show TNF Proteins) and MMP-9 (show MMP9 Proteins) up-regulation is most likely mediated via TLR4 (show TLR4 Proteins) recruitment into lipid rafts; clusterin has a role as an endogenous regulator for TLR4 (show TLR4 Proteins) signaling
susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin and Pycr1 (show PYCR1 Proteins) alterations
the antioxidant property of clusterin is suggested to regulate the expression of CCL20 (show CCL20 Proteins) in bronchial epithelial cells and the subsequent recruitment of inflammatory dendritic cells in the airway.
Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59 (show CD59 Proteins).
These results show that clusterin expression in porcine species is found in an own, as yet unidentified cell type during postnatal developmental stages.
Porcine spermatozoa may delivery CLU, PRM1 (show PRM1 Proteins) and PRM2 (show PRM2 Proteins) mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.
The expression of CLU gene was significantly higher among motility-impaired crossbred bull semen compared to the good quality one.
Clusterin haplotype AA may be a genetic marker on mastitis and other performance for Chinese Holstein cows.
The secretion of the potential zonal marker clusterin by zonal articular chondrocytes in osteoarthritic and healthy articular cartilage, was characterized.
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.
, clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
, aging-associated protein 4
, apolipoprotein J
, complement cytolysis inhibitor
, complement lysis inhibitor
, complement-associated protein SP-40,40
, ku70-binding protein 1
, sulfated glycoprotein 2
, testosterone-repressed prostate message 2
, dimeric acid glycoprotein
, testosterone repressed prostate message 2
, testosterone-repressed prostate message
, testostrone-repressed prostate message 2
, Apolipoprotein J
, testosterone repressed prostate message
, testosterone repressed prostate message-2
, glycoprotein 80
, apolipoprotein J/clusterin
, glycoprotein III
, apolipoprotein J)
, Sulfated glycoprotein 2