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Human Clusterin Protein expressed in Escherichia coli (E. coli) - ABIN1344142
Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages. in Journal of leukocyte biology 2011
Zebrafish clusterin is expressed in the notochord and nervous system during development. Clusterin has also role in neuronal cell death and thus, more generally, in neurodegeneration.
Data show that inhibition or targeted knockdown of Notch signaling significantly increased clusterin mRNA expression in choroid plexus.
The plasma levels of septin-9 and clusterin in ovarian cancer patients were abnormally elevated, which might be used as potential candidates of peripheral blood tumor biomarkers for early diagnosis of EOC and septin-9 might be related to distal metastases of EOC.
Data suggest that the potential of clusterin and glutathione synthetase (GSH-S) as platelet biomarkers for early detection of colorectal cancer (CRC) could improve existing screening modalities in clinical application.
recombinant alpha- and beta-chains exhibit structural and functional differences and differ in their sub-cellular localization.
miR-195 improved the sensitivity of resistant prostate cancer cells to docetaxel by suppressing CLU.
The VDR/MEG3/Clusterin signaling pathway may serve as potential therapeutic targets and prognosis biomarkers for colorectal cancer patients in future.
Meta analysis validated the Alzheimer disease protective association for CLU (rs11136000) variants.
that the Clusterin rs11136000 polymorphism C allele is associated with AD susceptibility
clusterin promotes growth and invasion in renal cell carcinoma cells in vitro and in vivo through upregulation of S100A4
The results showed that secreted CLU was overexpressed in three hepatocellular carcinoma cell lines. The downregulation of CLU by CLU shRNA synergistically increased Sorafenib sensitivity in the Bel7402 and SMMC7721 cells, and potentiated Sorafenib induced cell apoptosis.
Our study showed low clusterin immunostaining in colorectal carcinoma with lack of association with prognostic indicators
This study showed that the 1- and 2-year follow-up, generalized estimating equation analyses of Alzheimer's disease patients revealed that high levels of plasma clusterin at baseline were associated with a significantly larger decrease in Mini-Mental State Examination compared with low levels of plasma clusterin.
plasma level decreases in healthy but not in asthmatic pregnancy and correlates directly with lung function
Downregulation of apoE and apoJ in CSF strongly suggests a critical role of lipid metabolism in the development and progression of Moyamoya disease.
Our study may help to further elucidate the development and progression of non-small cell lung cancer , also it may contribute to the research of therapies targeting sCLU.
Using global proteomic profiling of brain leptomeningeal arteries, this study revealed that clusterin and tissue inhibitor of metalloproteinases-3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.
The presence of microbial invasion of the amniotic cavity, intra-amniotic inflammation (IAI), and microbial-associated IAI was characterized by lower amniotic fluid clusterin concentrations in pregnancies complicated by preterm prelabor rupture of membranes.
Our meta-analysis demonstrated that the rs9331888/C> G polymorphism in the clusterin gene might contribute to Alzheimer disease susceptibility especially in Caucasian populations.
these findings revealed that CLU genotypes could probably modulate the cerebral the Abeta loads on imaging and volume of hippocampus
No association for CLU with Alzheimer's disease in south-Indian population.
we confirm that a PEX/Alzheimer's Disease associated risk variant, rs2279590, resides within an enhancer element and regulates the expression of three candidate genes CLU, PTK2B and EPHX2, which were previously known to be modulators in the progression of Alzheimer's Disease.
Data identified sCLU as a regulator of mBMSCs lineage commitment to osteoblasts versus adipocytes through a mechanism mediated by ERK1/2 signaling. Inhibiting sCLU is a possible therapeutic approach for enhancing osteoblast differentiation and consequently bone formation.
Results of quantitative real-time polymerase chain reaction analysis showed that Clu mRNA levels in the inner ear were increased during embryogenesis and were constantly expressed in the adult.
Exposure of primary hippocampal neurons to Abeta42 induced an overexpression of intracellular clusterin, but the level of clusterin in supernatants did not change. Moreover, in APP/PSEN1 mice, there was a significant increase in intracellular clusterin in cortex and hippocampus, compared to age-matched wild-type (WT) mice, while serum clusterin level in APP/PSEN1 mice and in WT mice has no significant difference.
These findings suggest that in the absence of CLU, Abeta clearance shifts to perivascular drainage pathways, resulting in fewer parenchymal plaques but more CAA because of loss of CLU chaperone activity, complicating the potential therapeutic targeting of CLU for AD.
Sustained expression of clusterin in liver functioned as a preconditioning stimulus and prevented methionine and choline deficient (MCD) diet-induced severe steatohepatitis injury via Nrf2 activation.
Clusterin deficiency worsens renal inflammation and tissue fibrosis after ischemia-reperfusion injury in the kidney.
The results identify Clusterin as a new molecular partner involved in apoptotic cell efferocytosis and suggest a protective role for Clusterin in inflammation and autoimmune diseases.
Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD.
clusterin-induced TNF-alpha and MMP-9 up-regulation is most likely mediated via TLR4 recruitment into lipid rafts; clusterin has a role as an endogenous regulator for TLR4 signaling
susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin and Pycr1 alterations
the antioxidant property of clusterin is suggested to regulate the expression of CCL20 in bronchial epithelial cells and the subsequent recruitment of inflammatory dendritic cells in the airway.
these data suggest that activation of prosurvival autophagy by hypoxia in kidney cells requires CLU expression and may be a key cytoprotective mechanism of CLU in the protection of the kidney from hypoxia/ischemia-mediated injury.
Taken together, our results suggest that an NCE-box within the clusterin promoter is necessary for insulin-stimulated hepatic expression of clusterin via SREBP-1c.
Overexpression of clusterin in proximal tubular epithelial cells decreased the levels of Ang II-stimulated fibrotic markers and AT1R.
Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.
Results suggest that regulation of clusterin expression by the lymphotoxin beta signaling pathway and its protein dynamics during immune response suggest a specific role of in the immune system.
we have identified hypothalamic clusterin as a novel anorexigenic molecule that can potentiate central leptin activity.
This study provides the first evidence that sCLU reduces OC formation by inhibiting the actions of M-CSF, thereby suggesting its protective role in bone erosion.
results suggest that clusterin plays a protective role against high-fat diet-induced insulin resistance through the suppression of oxidative stress and inflammation.
These results showed that clusterin expression is modulated dynamically during development and by sensory activity.
Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59.
These results show that clusterin expression in porcine species is found in an own, as yet unidentified cell type during postnatal developmental stages.
Porcine spermatozoa may delivery CLU, PRM1 and PRM2 mRNAs to the oocyte, which may contribute to zygotic and early embryonic development.
The expression of CLU gene was significantly higher among motility-impaired crossbred bull semen compared to the good quality one.
Clusterin haplotype AA may be a genetic marker on mastitis and other performance for Chinese Holstein cows.
The secretion of the potential zonal marker clusterin by zonal articular chondrocytes in osteoarthritic and healthy articular cartilage, was characterized.
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.
, clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
, aging-associated protein 4
, apolipoprotein J
, complement cytolysis inhibitor
, complement lysis inhibitor
, complement-associated protein SP-40,40
, ku70-binding protein 1
, sulfated glycoprotein 2
, testosterone-repressed prostate message 2
, dimeric acid glycoprotein
, testosterone repressed prostate message 2
, testosterone-repressed prostate message
, testostrone-repressed prostate message 2
, Apolipoprotein J
, testosterone repressed prostate message
, testosterone repressed prostate message-2
, glycoprotein 80
, apolipoprotein J/clusterin
, glycoprotein III
, apolipoprotein J)
, Sulfated glycoprotein 2