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anti-Human MAL Antibodies:
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Human Polyclonal MAL Primary Antibody for ELISA - ABIN451626
Khor, Chapman, Vannberg, Dunne, Murphy, Ling, Frodsham, Walley, Kyrieleis, Khan, Aucan, Segal, Moore, Knox, Campbell, Lienhardt, Scott, Aaby, Sow, Grignani, Sillah, Sirugo, Peshu, Williams, Maitland et al.: A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. ... in Nature genetics 2007
The major allele A of rs2511521 located in DRD2 (show DRD2 Antibodies) and the minor allele T of rs625413 located in TIRAP (show TIRAP Antibodies) are significantly associated with increased risk of food addiction in overweight/obese subjects with low/zero food addiction symptoms.
Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (show TLR4 Antibodies) TIR domains and induce formation of MyD88 (show MYD88 Antibodies) assemblies.
Combined targeting of UBAP1 (show UBAP1 Antibodies) and toll (show TLR4 Antibodies)-like receptor adaptors TIRAP (show TIRAP Antibodies) and MyD88 (show MYD88 Antibodies) by Pseudomonas aeruginosa PumA (show BBC3 Antibodies) impedes both cytokine and toll (show TLR4 Antibodies)-like receptor signalling, highlighting a novel strategy for innate immune evasion.
Epistatic interaction between MyD88 (show MYD88 Antibodies) and TIRAP (show TIRAP Antibodies) against Helicobacter pylori.
Presence of at least one copy of the TIRAP (show TIRAP Antibodies) (2054C > T) variant may be associated with severity of bronchopulmonary dysplasia among preterm neonates.
MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer.
Results show that MAl protein binds to and regulates MYD88 (show MYD88 Antibodies).
This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia
TIRAP (show TIRAP Antibodies) polymorphisms are associated with progression and survival of patients with symptomatic myeloma.
Expression of the developmentally regulated proteolipid MAL is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
MAL (show TIRAP Antibodies) overexpression leads to reduced expression of Mpz and p75NTR (show NGFR Antibodies), despite functional pathways and normal expression of genes important for Schwann cell differentiation.
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Phagosomal retention of Francisella tularensis results in TIRAP/Mal (show TIRAP Antibodies)-independent TLR2 (show TLR2 Antibodies) signaling.
The specific reduction and mistargeting of MAL protein as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy.
Our results demonstrate a critical role for MAL in the maintenance of central nervous system paranodes, likely by controlling the trafficking and/or sorting of NF155 and other membrane components in oligodendrocytes.
Our results suggest a functional role for MAL in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.
SYP is an hexameric MAL-domain channel protein.
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.
T-lymphocyte maturation-associated protein
, myelin and lymphocyte protein
, MyD88 adapter-like protein
, Toll-like receptor adaptor protein
, adapter protein wyatt
, adaptor protein Wyatt
, toll/interleukin-1 receptor domain-containing adapter protein
, myelin and lymphocyte protein, T-cell differentiation protein
, Myelin and lymphocyte protein
, 17 kDa myelin vesicular protein
, NS 3
, VIP17 proteolipid
, VIP17/MAL proteolipid
, MAL-like protein