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Our results suggest that RAB10 could be a promising therapeutic target for Alzheimer's Disease prevention
RAB10 regulates cell survival and proliferation through multiple oncogenic, cell stress and apoptosis pathways. More importantly, high RAB10 expression levels in HCC (show FAM126A Proteins) cells correlated with a poor prognosis in HCC (show FAM126A Proteins) patients.
miR (show MLXIP Proteins)-329 also suppresses wound-healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo. Rab10 was identified as a target of miR (show MLXIP Proteins)-329 in osteosarcoma and mediates its biofunction
Data suggest that MGCRABGAP (show TBC1D21 Proteins) is involved in mammalian spermiogenesis by modulating RAB10.
the target gene RAB10 regulated by miRNA-369-3p, miRNA-30e-5p, miRNA-30e-3p, and miRNA-655 may play key role in the progression and development of AD.
The Anaplasma phagocytophilum surface protein, uridine monophosphate kinase (show UCK2 Proteins), was identified as a guanine nucleotide-independent, Rab10-specific ligand.
Rab10 is a target of the GTPase-activating protein (show RASA1 Proteins) AS160 (show TBC1D4 Proteins), which is inhibited after phosphorylation by the protein kinase (show CDK7 Proteins) Akt (show AKT1 Proteins).
Rab10 silencing increased the plasma membrane residence of HAS3 (show HAS3 Proteins), resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 overexpression suppressed hyaluronan synthesis.
Rab10 regulates endoplasmic reticulum dynamics/morphology. Suggest that these dynamics could be coupled to phospholipid synthesis.
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C
Rab10 plays a role in oligodendrocyte precursor cell maturation.
SEC16A (show INPP5E Proteins) and RAB10 promote insulin (show INS Proteins)-stimulated mobilization of GLUT4 (show SLC2A4 Proteins) from a perinuclear recycling endosome/trans Golgi network compartment.
Glut4 (show SLC2A4 Proteins) traffics predominantly through the specialized Rab10-dependent pathway both before and after insulin (show INS Proteins) stimulation.
role of Rab10 in mouse embryo
These results suggest that the association of Rab10-GTP (show AK3 Proteins) with Exoc6 (show EXOC6 Proteins)/6b is a molecular link between insulin (show INS Proteins) signaling and the exocytic machinery in GLUT4 (show SLC2A4 Proteins) translocation.
RAB10 and its GTPase-activating protein (show RASA1 Proteins) AS160 (show TBC1D4 Proteins) comprise the principal signaling module downstream of insulin receptor (show INSR Proteins) activation that regulates the accumulation of GLUT4 (show SLC2A4 Proteins) transport vesicles at the plasma membrane.
Rab10 coordinates with myosin-Va (show MYO5A Proteins) to mediate the final steps of insulin (show INS Proteins)-stimulated vesicle translocation to the plasma membrane.
show that continuous replenishment of TLR4 (show TLR4 Proteins) from Golgi to plasma membrane is regulated by the small GTPase (show RACGAP1 Proteins) Rab10, which is essential for optimal macrophage activation following ipopolysaccharide stimulation.
Rab10 is a target of AS160 (show TBC1D4 Proteins) and a positive regulator of GLUT4 (show SLC2A4 Proteins) trafficking to the cell surface upon insulin (show INS Proteins) stimulation.
Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development.
RAB10 belongs to the RAS (see HRAS\; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998
GTP-binding protein RAB10
, ras-related GTP-binding protein
, ras-related protein Rab-10
, ras-related protein rab10
, rab10 GTP-binding protein
, RAB10, member RAS oncogene family L homeolog
, ras-related GTP-binding protein RAB10