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Full name:: Staufen, RNA Binding Protein, Homolog 1 (Drosophila) Proteins (STAU1)

On www.antibodies-online.com are 6 Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) Proteins from 3 different suppliers available. Additionally we are shipping STAU1 Antibodies (66) and STAU1 Kits (1) and many more products for this protein. A total of 90 STAU1 products are currently listed.

Synonyms:: 5830401L18Rik, AW549911, C85792, CG5753, DKFZp459A0124, Dmel\\CG5753, Dmstau, dStau, fi67e05, MGC145034, stau, STAU1, Stauf, Staufen, Staufen1, wu:fi67e05, XStau, XStau1, zgc:77271

list all proteins	Gene Name	GeneID	UniProt
	STAU1	20853	Q9Z108
	STAU1	6780	O95793
Rat STAU1	STAU1	84496
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STAU1 Proteins (STAU1) by Origin

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Asymmetric Protein Localization

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More Proteins for STAU1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) interaction partners

The role of Miranda in the localization of Staufen during the division of neuroblasts is described.
Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number.
the expression of Adf (show CFL1 Proteins)-1 targets Staufen and Fasciclin II (show NCAM2 Proteins) (FasII), identified through larval brain ChIP-Seq for Adf (show CFL1 Proteins)-1, is negatively regulated by Adf (show CFL1 Proteins)-1, and manipulations of these genes predictably modify dendrite growth.
Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport.
Miranda has a role in coupling oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway

Mouse (Murine) Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) interaction partners

The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4 (show KLF4 Proteins)/Ddx5 (show DDX5 Proteins)/Stau1 axis during mammalian corticogenesis.
we suggest a model in which dynein's interaction with Staufen1 regulates mRNA localization along the axon and the synapses, and alterations in this process may correlate with synapse disruption and amyotrophic lateral sclerosis toxicity.
Collectively our results show that Staufen1 is highly expressed during early stages of differentiation/development and that it can impair differentiation by regulating c-myc (show MYC Proteins) thereby highlighting the multifunctional role of Staufen1 in skeletal muscle cell
For Stau1-mediated mRNA decay, Stau1 binds to the 3' untranslated region of target mRNA and recruits Upf1 (show UPF1 Proteins) to elicit rapid mRNA degradation.
Dvl2 (show DVL2 Proteins) has an inhibitory role in myogenesis and Stau1 coordinates myogenesis through the regulation of Dvl2 (show DVL2 Proteins) mRNA.
Expression of Stau1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase (show COMT Proteins)).
Identification of mRNA/protein (mRNP) complexes and their association with rough endoplasmic reticulum equipeed with a kinesin motor
Results suggest that Stau1 negatively regulates myogenesis in C2C12 myoblasts through a mechanism that is different from Stau1-mediated mRNA decay.
Staufen is present in the preimplantation mouse embryo
Stau1 is crucial for synapse development in vitro but not critical for normal behavioral function

Human Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) interaction partners

E2F1 (show E2F1 Proteins) induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B (show CDKN2B Proteins) signaling axis.
ADAR1p110 isoform competitively inhibits binding of Staufen1 to the 3'-untranslated-region dsRNAs and antagonizes Staufen1-mediated mRNA decay.
Stau1 is a stress response gene that remains efficiently translated during hypoxia and ER stress despite the substantial global inhibition of cap-dependent protein translation, promoting cell recovery following stress
Our findings suggest that HCV may appropriate Stau1 to its advantage to prevent PKR (show PKLR Proteins)-mediated inhibition of eIF2alpha (show EIF2A Proteins), which is required for the synthesis of HCV proteins for translocation of viral RNA genome to the polysomes for efficient translation and replication.
together, these data highlight the broad impact of Stau1 as a splicing regulator and suggest that Stau1 may act as a disease modifier in DM1.
expression of human Staufen1 is essential for proper dendritic arborisation during neuroblastoma (show ARHGEF16 Proteins) cell differentiation, yet it is not necessary for maintenance of differentiated state, and suggest potential human Stauf1 mRNA targets involved in the process
The changing pattern of STAU distribution during meiotic maturation of human oocytes implicates a novel mechanism for the regulation of protein synthesis based on mRNA localization
in vivo atlas of mRNA secondary structures recognized by Staufen 1
TINCR, together with Staufen1, seems to stabilize a subset of mRNAs required for epidermal differentiation.
Staufen1 is an important factor in HCV replication and it might play a role early in the HCV replication cycle, rather than virion morphogenesis.

Cow (Bovine) Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) interaction partners

STAU1 & STAU2 & ELAVL1 (show ELAVL1 Proteins) mRNAs & proteins were detected throughout cow preimplantation development (show MTA2 Proteins) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (show ELAVL2 Proteins) mRNAs were detectable from the GV to the morula stage; ELAVL2 (show ELAVL2 Proteins) protein was in all stages

Xenopus laevis Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) interaction partners

present in a ribonucleoprotein complex; associates with both a kinesin motor protein (show KIF16B Proteins) and vegetally localized RNAs Vg1 and VegT; results suggest a central role for Staufen in RNA localization in Xenopus oocytes

Zebrafish Staufen, RNA Binding Protein, Homolog 1 (Drosophila) (STAU1) interaction partners

Maternally expressed staufen is dispersed in the mature oocyte and early embryo. In the adult, staufen is expressed in specific brain nuclei, the testis, neurons and Leydig cells
stau1 is required for the survival and migration of primordial germ cells.

STAU1 Protein Profile

Protein Summary

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.

Alternative names and synonyms associated with STAU1

staufen double-stranded RNA binding protein 1 (STAU1)
staufen (stau)
staufen double-stranded RNA binding protein 1 (stau1)
RNA binding protein homolog (STAUFEN)
staufen (RNA binding protein) homolog 1 (Drosophila) (Stau1)
staufen double-stranded RNA binding protein 1 (Stau1)
staufen double-stranded RNA binding protein 1 L homeolog (stau1.L)

5830401L18Rik protein
AW549911 protein
C85792 protein
CG5753 protein
DKFZp459A0124 protein
Dmel\\CG5753 protein
Dmstau protein
dStau protein
fi67e05 protein
MGC145034 protein
stau protein
STAU1 protein
Stauf protein
Staufen protein
Staufen1 protein
wu:fi67e05 protein
XStau protein
XStau1 protein
zgc:77271 protein

Protein level used designations for STAU1

staufen, RNA binding protein, homolog 1 (Drosophila) , double-stranded RNA-binding protein Staufen homolog 1 , double-stranded RNA-binding protein Staufen homolog 1-like , CG5753-PA , CG5753-PB , CG5753-PC , stau-PA , stau-PB , stau-PC , stauffen , staufen, RNA binding protein, homolog 1 , Staufen 1 , staufen , RNA binding protein homolog , staufen RNA binding protein homolog 1

GENE ID	SPECIES
458319	Pan troglodytes
477258	Canis lupus familiaris
100056924	Equus caballus
100173606	Pongo abelii
100393512	Callithrix jacchus
100589756	Nomascus leucogenys
37065	Drosophila melanogaster
549296	Xenopus (Silurana) tropicalis
704197	Macaca mulatta
100049686	Sus scrofa
20853	Mus musculus
6780	Homo sapiens
513944	Bos taurus
84496	Rattus norvegicus
432335	Xenopus laevis
334440	Danio rerio
419213	Gallus gallus

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