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anti-Human Beclin 1 Antibodies:
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Human Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN153048
Gulati, Gaspers, Dann, Joaquin, Nobukuni, Natt, Kozma, Thomas, Thomas: Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. in Cell metabolism 2008
Show all 80 Pubmed References
Dog (Canine) Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN259945
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
Show all 35 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IF (cc), IF (p) - ABIN675384
Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. in Cancer letters 2013
Show all 9 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN3042322
Bu, Zhao, Zhang, Wang, Li, Yan: Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress. in American journal of cancer research 2016
Show all 7 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
Show all 12 Pubmed References
Polyclonal Beclin 1 Primary Antibody for IHC (fro), WB - ABIN540768
Massey, Kaushik, Sovak, Kiffin, Cuervo: Consequences of the selective blockage of chaperone-mediated autophagy. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 5 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN387797
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
Show all 10 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
Show all 11 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for WB - ABIN3044080
Wang, Ma, Hu, Xie, Wu, Zeng, Song: Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. in BMC cancer 2017
Show all 5 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for WB - ABIN6137526
Hang, Zhao, Su, Sun, Chen, Zhao, Du: Choline Inhibits Ischemia-Reperfusion-Induced Cardiomyocyte Autophagy in Rat Myocardium by Activating Akt/mTOR Signaling. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018
Show all 4 Pubmed References
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
these findings reveal a new regulatory mechanism of HSPB6 in cell survival through its interaction with BECN1.
High beclin1 expression is associated with Glioma.
Our data presents evidence that AEG-1, LC3-II, Beclin-1, and HIF-1alpha are significantly up-regulated in T-NHL tissues, and hypoxia triggers AEG-1, LC3-II and Beclin-1 expression in T-NHL cells.
Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric cancer were analyzed immunohistochemically for the expression of autophagic proteins microtubule-associated proteins 1A/1B light chain 3A and 3B (LC3A, LC3B) and beclin-1.
Study demonstrated that the expression of Beclin 1 was upregulated in 4nitroquinoline1oxideinduced oral carcinogenesis, accompanied with myeloidderived suppressor cells and regulatory T cells accumulation.
decreased Beclin-1 expression might relate to poor differentiation and unfavorable outcome in hepatocellular carcinoma
BECN1knockout inhibited the migratory and invasive ability of MDAMB231 cells by partially reversing signals of epithelial-mesenchymal transition.Analysis of publicly available gene expression datasets revealed increased expression of BECN1 in triple-negative breast cancer samples.
Low beclin 1 expression is associated with synovial sarcoma.
ISG15 reduces miR-17-5p levels and thereby promotes Beclin-1-mediated autophagy
CaMKII can directly phosphorylate Beclin 1 at Ser90 to promote K63-linked ubiquitination of Beclin 1 and activation of autophagy; it also promotes K63-linked ubiquitination of inhibitor of differentiation 1/2 (Id-1/2) by catalyzing phosphorylation of Id proteins and recruiting TRAF-6
PFN1 could promote autophagy through taking part in Beclin1 complex and contribute to bortezomib resistance, which may become a novel molecular target in the therapy of MM.
The results suggest that autophagy-associated proteins LC3A, LC3B, and Beclin-1 might be potential biomarkers for subclassification, differentiation, and local metastasis in primary lung tumor.
Silencing Beclin-1 can attenuate hypoxia-induced VM formation and the metastatic ability of U87MG cells and is a potential target for VM inhibition in glioma.
Endogenous HER2 interacts with Beclin 1 in breast cancer cells and inhibits autophagy. BECN1 allelic loss is common and associated with a worse prognosis in patients with HER2-overexpressing breast tumors.
To induce the redistribution of Beclin 1 among its self-associated form or Atg14L/UVRAG-containing complexes enhances both autophagy and endolysosomal trafficking.
Phosphorylated and activated deoxycytidine kinase inhibits ionizing radiation (IR)-induced total cell death and apoptosis, and promotes IR-induced autophagy through the mTOR pathway and by inhibiting the binding of Bcl2 protein to BECN1 in breast cancer cells.
Variation found in the BECN1 promoter modulates expression levels of this gene. Machado-Joseph Disease patients carrying the rs60221525 C allele presented a tendency for earlier estimated age at onset. Moreover, patients with the rs60221525 C allele presented a more severe clinical picture, compared to patients without this allele.
that after Caspase 3-mediated Beclin 1 cleavage at 146/149 sites, the N-terminal fragments of Beclin 1 may partially translocate into nuclei in neurons subjected to AD-like injury
miR-216b enhances the efficacy of vemurafenib and reverses drug resistance by targeting Beclin-1, UVRAG and ATG5 in melanoma.
TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity.
data demonstrate that disruption of the beclin 1-BCL2 complex is an effective mechanism to increase autophagy, prevent premature ageing, improve healthspan and promote longevity in mammals
HER2 interacts with Beclin 1 in breast cancer cells and inhibits autophagy. Mice with increased basal autophagy due to a genetically engineered mutation in Becn1 are protected from human HER2-driven mammary tumorigenesis, and HER2 fails to inhibit autophagy in primary cells derived from these mice.
Catalase ameliorates diabetes-induced cardiomyopathy through reduced RelA-mediated transcription of BECN1.
findings suggested E. faecalis LTA may increased macrophages autophagy via inhibiting PI3K/Akt/mTOR pathway and this process was Beclin1 dependent.
that TPT1 knockdown altered the BECN1 interactome, a representative MTOR-independent pathway, to stimulate autophagosome formation
The results suggest that SPK2 interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 and activating autophagy while protecting neurons against ischemic injury.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP activation, and enhanced macrophage beclin1 dependent autophagy.
These results suggest that the phosphorylated CAV1 functions to activate autophagy through binding to the BECN1/VPS34 complex under oxidative stress and to protect against ischemic damage.
Intracerebral hemorrhage contributes to microglia autophagic activation through BECN1 (and ATG5) pathway.
These data demonstrate the essential role of Beclin-1 in the formation of autophagosomes and lysosome biogenesis and underline that deletion of this key system is deleterious for cell viability.
AMP-activated protein kinase (AMPK) regulates autophagy by phosphorylating BECN1 at Thr388
BECN1/Beclin 1 binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2-AMPK-AKT-MTOR and CASP2-AMPK-MAPK by decreasing CASP2.
proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 and re-establishment of the autophagic pathway.
Genetically disrupting BECN1-BCL2 binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents Alzheimer's disease progression.
Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt/mTOR pathway in APP/PS1 transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease.
identify FAK as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
The results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes.
this study shows that knockdown of beclin1 enhances macrophage-associated phagocytosis and intracellular killing of Pseudomonas aeruginosa
provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1-PIK3C3 complex formation
A study of the expression of BECN1, LC3-II, and LAMP1 throughout the luteal phase of the estrous cycle in order to assess autophagy during corpus luteum development is reported.
Data indicate that the expression of MAP1LC3A, B and autophagy-associated genes (ATG5, mTOR, Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6