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anti-Human Beclin 1 Antibodies:
anti-Mouse (Murine) Beclin 1 Antibodies:
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Human Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN153048
Gulati, Gaspers, Dann, Joaquin, Nobukuni, Natt, Kozma, Thomas, Thomas: Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. in Cell metabolism 2008
Show all 73 Pubmed References
Dog (Canine) Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN259945
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
Show all 31 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN314194
Ko, Lin, Flomenberg, Pestell, Howell, Sotgia, Lisanti, Martinez-Outschoorn: Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. in Cancer biology & therapy 2012
Show all 16 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IF (cc), IF (p) - ABIN675384
Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. in Cancer letters 2013
Show all 8 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IP, ELISA - ABIN1583582
Russell, Tian, Yuan, Park, Chang, Kim, Kim, Neufeld, Dillin, Guan: ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. in Nature cell biology 2013
Show all 6 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN387797
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
Show all 9 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
Show all 10 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
Show all 10 Pubmed References
Monoclonal Beclin 1 Primary Antibody for IHC (fro), WB - ABIN534092
Aita, Liang, Murty, Pincus, Yu, Cayanis, Kalachikov, Gilliam, Levine: Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. in Genomics 1999
Show all 4 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN438264
Song, Qu, Guo, Zhao, Zhao, Gao, Sun, Shen, Wu, Wei: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. in Autophagy 2009
Show all 3 Pubmed References
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
autophagy induction stabilized microtubules by degrading SCG10 (show STMN2 Antibodies), a microtubule disassembly protein in neurons. In mice with spinal cord injury, local administration of a specific autophagy-inducing peptide, Tat (show TAT Antibodies)-beclin1, to lesion sites markedly attenuated axonal retraction of spinal dorsal column axons and cortical spinal tract and promoted regeneration of descending axons following long-term observation
Results provide evidence that Beclin-1 plays a major role in breast cancer subtypes, and identified AFF3 (show AFF3 Antibodies) as his direct target.
significantly different gene expressions of BECN1 and PRKCB (show PRKCB Antibodies) between the control and the Alzheimer's disease (AD) groups and of CDKN2A (show CDKN2A Antibodies) between the control and the preclinical AD groups, are reported.
EHMT2 (show EHMT2 Antibodies) can directly repress Beclin-1 and the inhibition of EHMT2 (show EHMT2 Antibodies) may be a useful therapeutic approach for cancer prevention by activating autophagy
oxidative stress activates the TRPM2 (show CLU Antibodies)-Ca(2 (show CA2 Antibodies)+)-CAMK2 (show CAMK2B Antibodies) cascade to phosphorylate BECN1 resulting in autophagy inhibition
Inhibition of Beclin-1 resulted in a dramatic decline of autophagy and increase of apoptosis in drug-resistant cells, accompanied by a remarkable reduction in S phase and a raise in G2/M phase of cell cycle and reverse the effect induced by miR (show MLXIP Antibodies)-30a-5p suppression.
AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)) regulates autophagy by phosphorylating BECN1 at Thr388
In patients treated with immunomodulatory drugs (IMiDs) lack of or low Beclin-1 expression resulted in a significantly improved OS and PFS compared to those treated with bortezomib or nonnovel agents.
beta-asarone changed the cellular morphology, inhibited cell proliferation, and enhanced the expression of P53 (show TP53 Antibodies), LC3 (show MAP1LC3A Antibodies)-II/I, Beclin-1, AMPK (show PRKAA1 Antibodies), and pAMPK while inhibiting the expression of P62 (show GTF2H1 Antibodies), Bcl-2 (show BCL2 Antibodies), mTOR (show FRAP1 Antibodies), and pmTOR in glioma cells.
PINK1 (show PINK1 Antibodies) silencing impaired BECN1 enrichment at mitochondria-associated membranes independently of PARK2 (show PARK2 Antibodies), suggesting a novel role for PINK1 (show PINK1 Antibodies) in regulating mitophagy.
Intracerebral hemorrhage contributes to microglia autophagic activation through BECN1 (and ATG5) pathway.
These data demonstrate the essential role of Beclin-1 in the formation of autophagosomes and lysosome biogenesis and underline that deletion of this key system is deleterious for cell viability.
BECN1/Beclin 1 binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2 (show CASP2 Antibodies)-AMPK (show PRKAA1 Antibodies)-AKT (show AKT1 Antibodies)-MTOR (show FRAP1 Antibodies) and CASP2 (show CASP2 Antibodies)-AMPK (show PRKAA1 Antibodies)-MAPK (show MAPK1 Antibodies) by decreasing CASP2 (show CASP2 Antibodies).
proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR (show CFTR Antibodies) mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 and re-establishment of the autophagic pathway.
Genetically disrupting BECN1-BCL2 (show BCL2 Antibodies) binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents Alzheimer's disease progression.
Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP (show APP Antibodies) and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway in APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease.
identify FAK (show PTK2 Antibodies) as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
The results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes.
this study shows that knockdown of beclin1 enhances macrophage-associated (show CD163 Antibodies) phagocytosis and intracellular killing of Pseudomonas aeruginosa
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6