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anti-Human Beclin 1 Antibodies:
anti-Mouse (Murine) Beclin 1 Antibodies:
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Human Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN153048
Gulati, Gaspers, Dann, Joaquin, Nobukuni, Natt, Kozma, Thomas, Thomas: Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. in Cell metabolism 2008
Show all 76 Pubmed References
Dog (Canine) Polyclonal Beclin 1 Primary Antibody for ICC, IF - ABIN259945
Liang, Kleeman, Jiang, Gordon, Goldman, Berry, Herman, Levine: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. in Journal of virology 1998
Show all 33 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN314194
Ko, Lin, Flomenberg, Pestell, Howell, Sotgia, Lisanti, Martinez-Outschoorn: Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. in Cancer biology & therapy 2012
Show all 16 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IF (cc), IF (p) - ABIN675384
Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. in Cancer letters 2013
Show all 9 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IP, ELISA - ABIN1583582
Russell, Tian, Yuan, Park, Chang, Kim, Kim, Neufeld, Dillin, Guan: ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. in Nature cell biology 2013
Show all 6 Pubmed References
Human Monoclonal Beclin 1 Primary Antibody for IF, IHC (p) - ABIN387797
Metzger, Saukko, Van Che, Tong, Puder, Riess, Nguyen: Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. in Human genetics 2010
Show all 9 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC (p), WB - ABIN388545
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
Show all 10 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for FACS, IHC (p) - ABIN388546
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
Show all 10 Pubmed References
Human Polyclonal Beclin 1 Primary Antibody for IHC, IHC (p) - ABIN438264
Song, Qu, Guo, Zhao, Zhao, Gao, Sun, Shen, Wu, Wei: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. in Autophagy 2009
Show all 3 Pubmed References
Monoclonal Beclin 1 Primary Antibody for IHC (fro), WB - ABIN534092
Aita, Liang, Murty, Pincus, Yu, Cayanis, Kalachikov, Gilliam, Levine: Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. in Genomics 1999
Show all 4 Pubmed References
Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
Variation found in the BECN1 promoter modulates expression levels of this gene. Machado-Joseph Disease patients carrying the rs60221525 C allele presented a tendency for earlier estimated age at onset. Moreover, patients with the rs60221525 C allele presented a more severe clinical picture, compared to patients without this allele.
that after Caspase 3 (show CASP3 Antibodies)-mediated Beclin 1 cleavage at 146/149 sites, the N-terminal fragments of Beclin 1 may partially translocate into nuclei in neurons subjected to AD-like injury
miR-216b enhances the efficacy of vemurafenib and reverses drug resistance by targeting Beclin-1, UVRAG and ATG5 in melanoma.
TRIM50 (show TRIM50 Antibodies), via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 (show ULK1 Antibodies) and autophagy activity.
The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 and Rab5a (show RAB5A Antibodies).
CISD2 (show CISD2 Antibodies) was increased in glioma samples and was associated with poor prognosis and aggressive tumor behavior. The miR449a/CISD2 (show CISD2 Antibodies)/beclin1mediated autophagy regulatory network contributed to the proliferation of glioma cells
low expression levels of Beclin 1 may contribute towards the degeneration of chondrocytes. Beclin 1 overexpression increased cell viability, inhibited apoptosis and MMPs, likely via the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway.
A construct lacking the C-terminal BARA (show LIN9 Antibodies) domain but including the coiled-coil region exhibits a homodimer KD 3.5-fold weaker than that of full-length BECN1, indicating that both the BARA (show LIN9 Antibodies) domain and the coiled-coil region of BECN1 contribute to dimer formation
While 3-methyladenine rescues cell damage. Our data thus suggest that I/R promotes NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) activity mediated Beclin 1-mediated autophagic flux, thereby exacerbating myocardial injury.
that TPT1 (show TPT1 Antibodies) knockdown altered the BECN1 interactome, a representative MTOR (show FRAP1 Antibodies)-independent pathway, to stimulate autophagosome formation
Catalase (show CAT Antibodies) ameliorates diabetes-induced cardiomyopathy through reduced RelA (show NFkBP65 Antibodies)-mediated transcription of BECN1.
findings suggested E. faecalis LTA (show LTA Antibodies) may increased macrophages autophagy via inhibiting PI3K/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway and this process was Beclin1 dependent.
The results suggest that SPK2 (show SPHK2 Antibodies) interacts with Bcl2 (show BCL2 Antibodies) via its BH3 domain, thereby dissociating it from Beclin-1 and activating autophagy while protecting neurons against ischemic injury.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha (show EIF2A Antibodies)-CHOP (show DDIT3 Antibodies) activation, and enhanced macrophage beclin1 dependent autophagy.
These results suggest that the phosphorylated CAV1 (show CAV1 Antibodies) functions to activate autophagy through binding to the BECN1/VPS34 (show PIK3C3 Antibodies) complex under oxidative stress and to protect against ischemic damage.
Intracerebral hemorrhage contributes to microglia autophagic activation through BECN1 (and ATG5) pathway.
These data demonstrate the essential role of Beclin-1 in the formation of autophagosomes and lysosome biogenesis and underline that deletion of this key system is deleterious for cell viability.
AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)) regulates autophagy by phosphorylating BECN1 at Thr388
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR (show FRAP1 Antibodies), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6