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Human Polyclonal GABARAPL2 Primary Antibody for FACS, IHC (p) - ABIN650659
Sou, Tanida, Komatsu, Ueno, Kominami: Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. in The Journal of biological chemistry 2006
Show all 4 Pubmed References
Human Polyclonal GABARAPL2 Primary Antibody for IHC, IHC (p) - ABIN4313669
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
This study reveals the important role of SERP1/Ysy6 and Atg8 in endoplasmic reticulum stress response and virulence in Candida albicans.
Mechanism of cargo-directed Atg8 conjugation during selective autophagy has been described.
Cardiolipin interaction with various Atg8 human orthologs, namely LC3B, GABARAPL2 and GABARAP, was investigated.
rs12599322 in ATG8 was significantly associated with higher DNA damage levels in Chinese population.
describe a protocol for the reconstituted conjugation systems for mammalian Atg8 homologs in vitro using purified recombinant Atg proteins and liposomes.
Using X-ray crystallography and NMR spectroscopy, the structural transition centered on the C-terminus of GATE-16 protein was identified.
Results showed that the mRNA and protein levels of GABARAPL1 and GATE-16 were decreased in the cerebellum of multiple system atrophy relative to controls
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
these results suggest that TRPML3 plays a role in autophagosome maturation through the interaction with GATE16, by providing Ca(2+) in the fusion process.
low GABARAPL2/GATE-16 expression is associated with an immature myeloid leukemic phenotype and these proteins are necessary for neutrophil differentiation of APL cells
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.
ATG8 proteins act as scaffolds for assembly of the ULK complex at the phagophore
Legionella pneumophila could interfere with autophagy by using the bacterial effector protein RavZ to directly uncouple Atg8 proteins attached to phosphatidylethanolamine on autophagosome membranes. [RavZ]
Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy
identified 14 TBC domain-containing Rab GAPs that bind directly to ATG8 modifiers and that colocalize with LC3-positive autophagy membranes in cells
The level of GABARAPs is decreased in Lewy body disease.
ORP7 negatively regulates GS28 protein stability via sequestration of GATE-16, and may mediate the effect of 25-OH on GS28 and Golgi function.
The GATE-16 N termini in general and specific residues needed for the fusion activity are essential for the proteins role in autophagosome biogenesis.
Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A for ATG8 substrates
analysis of human NSF possible binding mode to GABARAP and GATE-16
we characterized the Xenopus laevis xAtg4B protease along with two of its substrates, xLC3B and xGATE16. More specifically, we were interested in finding well-behaved and stable protease fragments with optimal proteolytic activity
Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. Gate-16 specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate uniform distribution of interferon-inducible GTPases. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of IFN-inducible GTPases.
Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).
GABA(A) receptor-associated protein-like 2
, gamma-aminobutyric acid receptor-associated protein-like 2
, ganglioside expression factor 2
, golgi-associated ATPase enhancer of 16 kDa
, MAP1 light chain 3 related protein
, MAP1 light chain 3-related protein
, general protein transport factor p16
, GABA(A) receptor-associated protein like 2
, gamma-aminobutyric acid (GABA-A) receptor-associated protein-like 2