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Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.
membrane targeting of ELMO via Arl4A promotes cytoskeletal reorganization including membrane ruffling and stress fiber disassembly via an ELMO-DOCK1800-Rac (show AKT1 Proteins) signaling pathway.
Study shows that three related Arf-like GTPases Arl4a, Arl4c (show ARL4C Proteins), and Arl4d (show ARL4D Proteins), are able to recruit ARNO (show CYTH2 Proteins) and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form.
The loss of PTEN was shown to lead to increased levels of ARF4L protein but no change in transcript levels. The ARF4L transcript preferentially localized to the polysomal compartment after PTEN loss in glioma.
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
This gene was a target of WNT (show WNT2 Proteins) signlaing in the dorsal somite.
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor-like 4A
, ADP-ribosylation factor-like 4a
, ADP-ribosylation factor-like protein 4a
, ADP-ribosylation factor-like 4
, ADP-ribosylation factor-like protein 4A
, ADP-ribosylation-like 4