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a decision analysis comparing allo-HCT vs chemotherapy in first complete remission for patients with cytogenetically intermediate-risk acute myeloid leukemia (show BCL11A Proteins), depending on the presence or absence of FLT3 (show FLT3 Proteins)-ITD), NPM1 (show NPM1 Proteins), and CEBPA mutations showed that allo-HCT was a favored postremission strategy in patients with FLT3 (show FLT3 Proteins)-ITD, and chemotherapy was favored in patients with biallelic CEBPA mutations.
This is the first study providing evidence that the c.690G>T, p.(Thr230Thr) (rs34529039) polymorphism of the CEBPA gene, together with up-regulation of its mRNA expression, are negative factors worsening ovarian cancer outcome
CSF3R (show CSF3R Proteins) mutations co-occur with CEBPA mutations in pediatric acute myeloid leukemia (show BCL11A Proteins).
While much is known about how C/EBPalpha orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPalpha deregulation in leukemia remains elusive. In this review, we will summarize the latest research addressing these topics with special emphasis on CEBPA mutations
miR-182 is a strong regulator of C/EBPalpha. There is a regulatory loop between C/ (show MLXIP Proteins)EBPalpha and miR-182. While C/EBPalpha blocks miR-182 expression by direct promoter binding during myeloid differentiation, enforced expression of miR-182 reduces C/EBPalpha protein level and impairs granulopoiesis in vitro and in vivo.
CHOP (show DDIT3 Proteins) negatively regulates Polo-like kinase 2 (show PLK2 Proteins) expression via recruiting C/EBPalpha to the upstream-promoter in human osteosarcoma cell line during ER stress
C/EBPalpha overexpression suppressed the epithelial-mesenchymal transition (EMT (show ITK Proteins)) that was characterized by a gain of epithelial and loss of mesenchymal markers. Further study showed that C/EBPalpha suppressed the transcription of beta-catenin (show CTNNB1 Proteins) and downregulated the levels of its downstream targets.
Binding of C/EBPalpha was associated with increased deacetylation near the transcription start site (TSS) of the PLK1 promoter.
a MEF2C and CEBPA correlation in CML disease progression
CEBPA gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.
The Bach2 (show BACH2 Proteins)-C/EBPbeta (show CEBPB Proteins) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.
Data demonstrate the importance of a controlled balance between C/EBPalpha and miR (show MLXIP Proteins)-182 for the maintenance of healthy granulopoiesis.
Functional characterization of C/EBPa and C/EBPb (show CEBPB Proteins) proteomes suggests they can regulate novel pathways.
results indicate that JMJD2B regulates PPARgamma (show PPARG Proteins) and C/EBPalpha during adipogenesis
A single +42-kb enhancer is essential for CEBPA expression in myeloid cells only.
these data indicate that CycC (show CCNC Proteins) activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha.
Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha, PPAR-gamma (show PPARG Proteins), FAS (show FAS Proteins), perilipin A (show PLIN1 Proteins), and STAT-3 (show STAT3 Proteins).
we show that SIX1 (show SIX1 Proteins) binds to adipogenic and brown marker genes and interacts with C/EBPa, C/EBPb (show CEBPB Proteins) and EBF2 (show EBF2 Proteins), suggesting their functional cooperation during adipogenesis.
these results indicate that C/EBPalpha functions throughout osteoclastogenesis as well as in Osteoclast function. This study provides additional understanding of the roles of C/EBPalpha in Osteoclast biology.
the DNA sequences to which EVI1 (show MECOM Proteins) binds at +35 and +37 kb and show that mutation of one of these releases Cebpa from EVI1 (show MECOM Proteins)-induced suppression.
C/ebpalpha plays a role in liver growth regulation via the p53 (show TP53 Proteins) pathway.
Dnmt1 (show DNMT1 Proteins) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (show ALDH1L1 Proteins)) involving CEBPalpha helps relieve embryonic oxidative stress induced (show SQSTM1 Proteins) by ethanol exposure.
Bmi1 (show BMI1 Proteins) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (show SUMO1 Proteins), SUMO2 (show SUMO2 Proteins), and SUMO3 (show SUMO3 Proteins)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (show CTNNA1 Proteins) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (show IL6 Proteins)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (show MSTN Proteins) in muscles were higher in the concentrate-fed group than in the grass hay (show GTF2H5 Proteins)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha