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anti-Human COX2 Antibodies:
anti-Mouse (Murine) COX2 Antibodies:
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Human Monoclonal COX2 Primary Antibody for IP, IHC - ABIN3210019
Cheng, Whitehead, Hachinski, Cechetto: Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the rat. in Neurobiology of disease 2006
Studied role of HPV16 E6 and COX-2 in invasive ductal breast cancer using qPCR and IHC, and in vitro studies. Found HPV16 E6 promoted breast cancer proliferation; Cox-2 inhibition suppressed HPV16 E6 effects on proliferation thru NF-kappaB (show NFKB1 Antibodies) signaling pathway.
reviews the cardiovascular effects of COX-2 inhibitors with a focus on the mechanisms contributing to the clinical readouts of COX-2 inhibition.
Colorectal carcinoma harboring ALK (show ALK Antibodies) fusions represent a rare aggressive subtype of colorectal carcinoma with distinct clinicopathologic features. This report provides the first clinical evidence that such patients may benefit from targeted monotherapy with ALK (show ALK Antibodies) inhibitors.
This finding may provide a new option besides COX (show COX8A Antibodies) inhibition to optimize cancer therapy. The outcome of this translational research will guide us to develop a novel omega-6-based diet-care strategy in combination with current chemotherapy for colon cancer prevention and treatment.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (show FOSB Antibodies) which, in turn, induces COX-2 expression.
A single SNP (rs689466) localized at 5' -1192 of the PTGS2 (show PTGS2 Antibodies) gene exhibited significant association with febrile seizure (FS) based on case-control allelic association analyses. A significant decrease in the frequency of the G allele in FS was observed compared to that in controls. Using case-control genotypic association analysis, the -1192A allele is most likely to confer susceptibility to FS by a recessive action model.
The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability
High PTGS2 (show PTGS2 Antibodies) expression is associated with metastasis of esophageal squamous cell cancer.
Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B (show PTPN1 Antibodies), which in turn activates the epidermal growth factor receptor (show EGFR Antibodies)-p38 mitogen-activated protein kinase (show MAPK14 Antibodies) pathway that induces cyclooxygenase-2 (show PTGS2 Antibodies) expression.
Cobalt protoporphyrin induces COX-2 expression through activating P2X7 (show P2RX7 Antibodies) receptors and ASK1 (show MAP3K5 Antibodies)/MAP kinases as well as PIAS1 (show PIAS1 Antibodies) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (show JUN Antibodies) which, in turn, induces COX-2 expression.
Results indicate that Cox-2 promotes Col10a1 (show COL10A1 Antibodies) expression and chondrocyte hypertrophy in vitro.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (show ROS1 Antibodies) in macrophages.
Our data suggest that there are physiologically important gender differences in hypoxic acclimatization in COX-2-deficient mice. The COX-2 signaling pathway appears to be required for acclimatization in oxygen-limiting environments only in males, whereas female COX-2-deficient mice may be able to access COX-2-independent mechanisms to achieve hypoxic acclimatization.
increased COX2 expression has an impact on the aging process
These results establish a novel signaling process whereby PAK1 (show PAK1 Antibodies) upregulates COX-2, reduces anandamide levels and restricts tonic endocannabinoids-mediated processes.
Angiotensin II-AT1-receptor (show AGTRAP Antibodies) signaling is necessary for COX-2-dependent normal postnatal nephrogenesis and maturation.
AhR (show AHR Antibodies) controls COX-2 protein via mRNA stability.
Podocyte-specific knockout of COX2 enhanced albuminuria and did not attenuate the histologic features of diabetic kidney disease.
B1 receptors are coupled to COX2 (show PTGS2 Antibodies) in causing endothelium-independent contractions in endotoxin-treated pig coronary arteries
Expression of COX-2 (show PTGS2 Antibodies) was strongest in gilts with acute endometritis, but did not differ between those with chronic endometritis and normal endometrium.
Data indicate that the proton-pumping pathway of heart cytochrome c (show CYCS Antibodies) oxidase includes a hydrogen-bond network and a water channel (show AQP4 Antibodies) located in tandem between the positive and negative side of the mitochondrial membrane.
Study suggests that His503 is involved in the proton supply to the D-path as a proton acceptor in cytochrome c (show CYCS Antibodies) oxidase.
Data suggest that the axial Met residue moderately increased the redox potential of the Cu(A) site in cytochrome c (show CYCS Antibodies) oxidase.
Studies indicate that heart cytochrome c (show CYCS Antibodies) oxidase subunits I, II and III are encoded by the mitochondrial genome.
extensive pre- and intrapartal rise of COX (show COX7A1 Antibodies)-II expression in bovine placentomes with a 70-100-fold increase of COX (show COX7A1 Antibodies)-II-mRNA levels
Pretreatment of cells with selective COX-2 blocker etodolac markedly inhibited ICl.
Safflower injection may attenuate lung ischemia/reperfusion injury through inhibiting cyclooxygenase-2 (show PTGS2 Antibodies) expression.
The RNA interference targeting COX-2 can effectively inhibit the expression of COX-2 and MMP-2 (show MMP2 Antibodies) in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, cytochrome c oxidase subunit II
, cytochrome c oxidase subunit ii
, cytochrome C oxidase subunit II