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anti-Human RARRES2 Antibodies:
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Mouse (Murine) Polyclonal RARRES2 Primary Antibody for IF (cc), IF (p) - ABIN1715135
Krautbauer, Wanninger, Eisinger, Hader, Beck, Kopp, Schmid, Weiss, Dorn, Buechler: Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver. in Experimental and molecular pathology 2013
Show all 3 Pubmed References
Mouse (Murine) Polyclonal RARRES2 Primary Antibody for IHC (p) - ABIN1701633
Gonzalvo-Feo, Del Prete, Pruenster, Salvi, Wang, Sironi, Bierschenk, Sperandio, Vecchi, Sozzani: Endothelial cell-derived chemerin promotes dendritic cell transmigration. in Journal of immunology (Baltimore, Md. : 1950) 2014
Results show that rs3735167 is the lead RARRES2 polymorphism for chemerin levels in Taiwanese. Chemerin levels, but not the rs3735167 genotypes, predicted the long-term outcome of coronary artery disease.
Current knowledge about the relationship between chemerin and lower gastrointestinal (GI) diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and colorectal cancer (CRC) is REVIEWED.
Chemerin upregulated expression and phosphatase activity of PTEN by interfering with PTEN-CMKLR1 interaction, leading to weakened ubiquitination of PTEN and decreased p-Akt (Ser473) level, which was responsible for suppressed migration, invasion and metastasis of HCC cells.
the strong association of chemerin and fetuin-A with insulin resistance and some inflammatory markers may provide an interesting link between obesity, inflammation and diabetes mellitus
Data show that chymase cleavage of chemerin (chem163S) to partially active chemerin (chem156F) can be found in synovial fluids where it can play a role in modulation of the inflammation in joints.
FXIa, generated on contact phase activation, cleaves chem163S to generate chem158K, which can be further processed to the most active chemerin form, providing a molecular link between coagulation and inflammation.
Circulating chemerin is increased and correlates to inflammatory parameters in patients with advanced carotid stenosis.
chemerin and leptin are elevated and omentin-1 and visfatin levels are decreased in Gestational diabetes mellitus women complicated by obesity.
The elevated levels of circulating TIG2 (chemerin) were associated with gestational diabetes mellitus.[meta-analysis]
This study show the serum PARRES2 levels had significant positive correlation with seizure severity Chalfont score and the duration of epilepsy.
findings of this study suggest that chemerin in synovial fluid may play role as a predisposing factor and may represent a novel potential prognostic biochemical marker in the pathogenesis of temporomandibular joint disorders
G allele of chemerin rs17173608 compared to T allele decreased the risk of end-stage renal disease in a sample of Iranian population.
Data suggest that down-regulation of serum levels of chemerin (an inflammatory cytokine biomarker) can occur in weight-loss therapy as short in duration as 4-week aerobic exercise plus dieting in obese female adolescents; this effect was not observed by dieting alone. This study was conducted in weight-loss summer camp in China.
results demonstrate a strong inverse association between serum chemerin levels and renal function.
The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers.
Data suggest that, in overweight and obese subjects, weight reduction induces changes in chemerin serum levels in parallel with adiponectin plasma levels; chemerin is down-regulated and adiponectin is up-regulated in both insulin-resistant and insulin-sensitive subjects after weight reduction; however, only changes in chemerin in insulin-sensitive subjects were found to be statistically significant.
No associations were observed between SNPs in RARRES2 and obesity.
Serum chemerin level during the first trimester of pregnancy has the potential to predict risk of gestational diabetes mellitus.
The SD to LD transition was mimicked by 2 weeks of ICV infusion of human chemerin into rats. It also increased expression of the cytoskeletal protein vimentin, implicating hypothalamic remodeling in this response.Acute ICV bolus injection of chemerin on a 12 h:12 h photoperiod inhibited food intake and decreased body weight with associated changes in hypothalamic neuropeptides involved in growth and feeding after 24 hr.
We studied the association between retinoic acid receptor responder 2 rs17173608 and rs4721 gene polymorphisms and gestational diabetes mellitus. We found that RARRES2 rs4721 polymorphism increased the risk of gestational diabetes mellitus. RARRES2 rs17173608 polymorphism is not associated with gestational diabetes mellitus.
Total serum chemerin levels and ex vivo CMKLR1 and GPR1 activation were significantly induced in high fat diet.
findings show that chemerin-activated CMKLR1 regulation in inflammatory macrophages is largely GRK6 and beta-arrestin mediated, which may impact innate immunity and have therapeutic implications in rheumatic disease.
Systemic and hepatic chemerin, and chemerin receptor activation were not changed in hepatocellular carcinoma. Chemerin protein was induced in liver in NASH, but was unchanged in HCC tissues. Hepatic and serum chemerin and ex vivo analyzed chemerin receptor activation do not differ in murine NASH-associated HCC when compared to NASH.
endogenously secreted chemerin plays an autocrine/paracrine role in white adipose tissue, identifying chemerin as a therapeutic target to modulate adipose remodelling.
elevated levels of chemerin were found in colons of mice with experimental colitis, and a neutralizing anti-chemerin antibody improved intestinal inflammation
Data suggest a potential role for chemerin and CMKLR1 in the regulation of inflammatory responses in the tumor microenvironment.
Suggest reduction of chemerin could contribute to the antiobesity/antidiabetic properties described for alpha-lipoic acid.
Study indicates that Chemerin plays a role in the negative cross-talk between skeletal muscle and adipose tissue. Specifically, Chemerin promotes the adipogenic differentiation potential and alters the myoblast cell fate from myogenesis to adipogenesis.
Data indicate that chemerin may play an important role in regulating mitochondrial remodelling and function in skeletal muscle.
The chemerin15 (C15) precursor, chemerin, and its receptor, ChemR23, are both upregulated after skin damage and the receptor is expressed by macrophages, neutrophils, and keratinocytes. C15 delivery dampens immediate inflammatory events.
findings reveal previously uncharacterized regulators of chemerin expression in skin and identify a physiologic role for chemerin in skin barrier defense against microbial pathogens.
A novel autocrine/paracrine role for chemerin in regulating osteoclast differentiation of hematopoietic stem cells
this study reports that retinoic acid-activated endothelial cells can promote myeloid and plasmacytoid dendritic cell transmigration across endothelial cell monolayers through the endogenous production of chemerin
Data suggest that chemerin/ChemR23 (chemokine-like receptor 1) signaling is not essential for adipocyte differentiation, but it appears to play a role in control of body weight and energy metabolism as overweight/obesity progresses.
Studies using isolated islets and perfused pancreas revealed impaired glucose-dependent insulin secretion (GSIS) in chemerin-deficient mice. Conversely, chemerin transgenic mice revealed enhanced GSIS and improved glucose tolerance.
Following TNFalpha treatment, increased elastase and tryptase modify the balance between activation and deactivation, elevating active chemerin concentration in adipocyte media and subsequent CMKLR1 activation.
results of this study indicate that chemerin plays a role in the negative cross-talk between skeletal muscle and adipose tissue to regulate myogenesis
Downstream targets of Chemerin/ChemR23 signaling are phosphorylated in vitro and are expressed in mouse tooth development, suggesting roles for Chemerin/ChemR23-mediated epithelial-mesenchymal cell signaling during tooth morphogenesis.
These results rule out the direct anti-inflammatory effect of chemerin on macrophages ex vivo, described previously in the literature, despite the expression of a functional ChemR23 receptor in these cells.
Chemerin increases in airways during viral infection; Chemerin appears to have anti-inflammatory properties, by acting on ChemR23 expressed by non-leukocytic cells dampening the inflammatory response promoted by the viral infection; the chemerin/ChemR23 system plays important roles in the physiopathology of viral pneumonia
Chemerin regulates energy metabolism partly through the Akt and ERK1/2 signaling pathways.
Data show that the fat and energy moblization during lactation influences circulating retinoic acid receptor responder protein 2 (RARRES2) levels as well as the expression of RARRES2 and chemokine-like receptor 1 (CMKLR1) in subcutaneous adipose tissue (SAT) and ovarian cells.
These results suggest that Chemerin promotes lipolysis in mature adipocytes and induces adipogenesis during preadipocyte re-differentiation, further indicating a dual role for Chemerin in the deposition of intramuscular fat in ruminant animals.
chemerin is a novel regulator of lactogenesis via its own receptor in bovine mammary epithelial cells
This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein.
RAR-responsive protein TIG2
, retinoic acid receptor responder protein 2
, tazarotene-induced gene 2 protein
, CHO functionally unknown type II transmembrane protein
, Tazarotene-induced gene 2 protein