Browse our anti-Adenosine A2b Receptor (ADORA2B) Antibodies

Zebrafish Adenosine A2b Receptor (ADORA2B) interaction partners

1. activation of PPARalpha (show PPARA Antibodies) promoted angiogenesis just as activation of A2B receptors through an epoxide dependent mechanism

Pig (Porcine) Adenosine A2b Receptor (ADORA2B) interaction partners

1. mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Antibodies)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Antibodies)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells

Human Adenosine A2b Receptor (ADORA2B) interaction partners

1. findings suggest that hypoxia, through HIF1A (show HIF1A Antibodies), contributes to the development and progression of pulmonary fibrosis through its regulation of ADORA2B expression on alternatively activated macrophages, cell differentiation, and production of profibrotic mediators

2. The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS (show ROS1 Antibodies) production in colorectal cancer cells via adenosine receptor-independent mechanism.

3. the effects of TNF-alpha (show TNF Antibodies) were investigated on the expression/responsiveness of the A2B adenosine receptor (A2BAR), a Gs-coupled receptor that promotes mesenchymal stem cell (MSC (show MSC Antibodies)) differentiation into osteoblasts.

4. Actinin (show ACTN1 Antibodies)-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression

5. cells lacking A2b do not respond in this manner to hypoxia or ATP but transfection of A2b restores this response, that Epac1 (show RAPGEF3 Antibodies) is critically involved, and that Rap1B (show RAP1B Antibodies) is important for the relative positioning of the centrosome and nucleus.

6. Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. [review]

7. Findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.

8. erythrocyte AMP-activated protein kinase (show PRKAA2 Antibodies) was activated in humans at high altitude. It is a key protein functioning downstream of the A2B adenosine receptor, phosphorylating and activating BPG mutase and thus inducing 2,3-BPG production and O2 release from erythrocytes.

9. A2B receptor activation is critically required for the stimulatory effect of adenosine on IL-10 (show IL10 Antibodies) production and suppression of nitric oxide release.

10. Data show that ADORA2B mRNA and protein were significantly up-regulated in oral squamous cell carcinoma (OSCC) and that ADORA2B controls cellular proliferation via HIF-1alpha (show HIF1A Antibodies) activation, suggesting it may be a key regulator of tumoral progression in OSCCs.

Mouse (Murine) Adenosine A2b Receptor (ADORA2B) interaction partners

1. Obesity is related with a condition of colonic inflammation, leading to an increase of A2BR expression. A2BR, modulating the activity of excitatory tachykininergic nerves, participate to the enteric dysmotility associated with obesity.

2. these results suggest that A2BAR stimulation inhibits the activation of ERK1/2, p38 (show CRK Antibodies) and NF-kappaB (show NFKB1 Antibodies) by RANKL (show TNFSF11 Antibodies), which suppresses the induction of osteoclast marker genes, thus contributing to the decrease in osteoclast cell-cell fusion and bone resorption activity.

3. the pivotal role of CXCR4 (show CXCR4 Antibodies)- and CXCR7 (show CXCR7 Antibodies)-inhibition in acute pulmonary inflammation, which depended on A2B-receptor signaling, is reported.

4. Adora2B stimulation promotes FGF2 (show FGF2 Antibodies) and CXCL12 (show CXCL12 Antibodies) expression in FAP (show FAP Antibodies)-positive melanoma-associated (show ZNF654 Antibodies) fibroblasts, contributing to the creation of a tumor-promoting microenvironment.

5. activation of adenosine A2B receptors on myeloid cells caused nociceptor hyperexcitability and promoted chronic pain via soluble IL-6 (show IL6 Antibodies) receptor trans-signaling.

6. findings suggest that hypoxia, through HIF1A (show HIF1A Antibodies), contributes to the development and progression of pulmonary fibrosis through its regulation of ADORA2B expression on alternatively activated macrophages, cell differentiation, and production of profibrotic mediators

7. It has been reported that signaling through hepatocellular Adora2b adenosine receptors dampens IR injury of the liver.

8. Diabetes resulted in an increased A2A/A2B receptor expression in coronary arteries which resulted in enhanced A2A/A2B-mediated increase in coronary flow observed in diabetic hearts.

9. A2B adenosine receptor-induced VEGF (show VEGFA Antibodies) production and angiogenesis are involved in myeloid-derived suppressor cells in a mouse melanoma model

10. Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors

Cow (Bovine) Adenosine A2b Receptor (ADORA2B) interaction partners

1. Purinergic stimulation of cilia beat frequency requires A(2B (show ADRA2B Antibodies)) adenosine receptor activation, likely via protein kinase A-dependent pathway.

2. It is likely that adenosine acts through A(2B (show ADRA2B Antibodies)) receptors and adenylyl cyclases to stimulate CNGA2 (show CNGA2 Antibodies).

Rabbit Adenosine A2b Receptor (ADORA2B) interaction partners

1. Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Antibodies)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.