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Studies indicate the importance of the AKAP79/PP2B (show CAN ELISA Kits)/protein kinase A complex's role in synaptic long-term depression in the CA1 (show CA1 ELISA Kits) region of the hippocampus.
Cigarette smoke-induced changes in AKAP5 and AKAP12 (show AKAP12 ELISA Kits) in patients with COPD (show ARCN1 ELISA Kits) may affect efficacy of pharmacotherapy.
human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330
GPR30 (show GPER ELISA Kits) interacted with membrane-associated guanylate kinases and protein kinase A-anchoring protein (show AKAP10 ELISA Kits) (AKAP) 5 in the plasma membrane in a PDZ (show INADL ELISA Kits)-dependent manner.
a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.
Patients with bipolar disorder have higher density of AKAP5-expressing neurons in the anterior cingulate cortex compared with controls.
AKAP79, PKC, PKA and PDE4 (show PDE4A ELISA Kits) participate in a Gq-linked muscarinic receptor (show CHRM5 ELISA Kits) and adenylate cyclase 2 (show ADCY2 ELISA Kits) cAMP signalling complex.
The results of this study suggested that antagonizing the TRPV1 (show TRPV1 ELISA Kits)-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia.
AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli.
Antagonizing the interaction between AKAP79 and TRPV1 (show TRPV1 ELISA Kits) inhibits inflammatory hyperalgesia.
the C-helix of protein kinase A inhibitory regulatory subunit is identified as a highly dynamic switch which relays cyclic AMP (show TMPRSS5 ELISA Kits) binding to the helical catalytic-subunit binding regions
AKAP150 regulates Ca(2 (show CA2 ELISA Kits)+ )cycling and myocardial ionotropy following pathological stress, promoting pathological remodelling and heart failure propensity.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
This study demonstrated that the AKAP150 oordinates metabotropic glutamate (show GRIN1 ELISA Kits) receptor sensitization of peripheral sensory neurons.
Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities.
Identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII (show CAMK2G ELISA Kits) and highlight a significant role for cardiac beta-ARs (show SLURP1 ELISA Kits) in this phenomenon.
endothelial-dependent dilation of resistance arteries is enabled by MEP (show CTSL1 ELISA Kits)-localized AKAP150, which ensures the proximity of PKC (show PKC ELISA Kits) to TRPV4 (show TRPV4 ELISA Kits) channels and the coupled channel gating necessary for efficient communication from endothelial to smooth muscle cells
Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa (show KCNMA1 ELISA Kits) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
Anchoring of protein kinase A and adenylyl cyclase by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA (show GRIA3 ELISA Kits) receptor activity.
the direct anchoring of both PKA and AC to TRPV1 (show TRPV1 ELISA Kits) by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
A kinase (PRKA) anchor protein 5
, A-kinase anchor protein 5
, A-kinase anchor protein 5-like
, a-kinase anchor protein 5-like
, A-kinase anchor protein 79 kDa
, A-kinase anchor protein, 79kDa
, A-kinase anchoring protein 75/79
, AKAP 79
, cAMP-dependent protein kinase regulatory subunit II high affinity binding protein
, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
, A-kinase anchor protein 75 kDa
, AKAP 75
, anchor protein regulatory subunit (AKAP75)
, A-kinase anchor protein 150 kDa
, AKAP 150
, RII-B-binding protein