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Zebrafish larvae lacking beta1AR (show ADRB1 Proteins) expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
we identified the beta2 adrenergic receptor (ADRB2) as a downstream target for PHD3 (show EGLN3 Proteins) in skeletal muscle
Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6 (show GAS6 Proteins)) expressed by osteoblasts.
Adrenergic Receptor beta-2 signaling in the airway epithelium promotes eosinophilic inflammation, mucous metaplasia, and airway contractility.
the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR (show ADRB1 Proteins) TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (show SCP2 Proteins)), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C Proteins) and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.
activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP (show APP Proteins) at Thr668
Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin (show INS Proteins)-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes
beta2-AR deletion is associated to selective hepatic insulin (show INS Proteins) resistance and preserved skeletal muscle insulin (show INS Proteins) sensitivity.
The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.
knocking out of the beta1/2 (show TFAP2B Proteins) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor (show NR3C1 Proteins) with neonatal glucose and lipid metabolism.
ADRb2 shows lipid scrambling activity.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R (show OXTR Proteins)) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
The authors suggest that increased circulating beta2-adrenergic receptor autoantibodies are associated with smoking-related emphysema.
These results suggested that adrenergic stimulation via beta1- and beta2-adrenergic receptors in the human endolymphatic sac (show ADCY10 Proteins) was involved in regulation of inner ear fluid ion homeostasis
Phosphopeptide ligation onto the beta2-adrenergic receptor (beta2AR) allows stabilization of a high-affinity receptor active state by beta-arrestin1 (show ARRB1 Proteins).
This study provided proof that SNPs within ADRB2 is significantly associated with the susceptibility to and the prognosis of cervical vertigo, so that NPY (show NPY Proteins) and NA might serve as the precise diagnostic marker and treatment target of cervical vertigo.
A functional SNP (rs12654778), upstream of ADRB2, was significantly associated with increased risk for COPD (show ARCN1 Proteins).
Data indicate clustering of beta-2 adrenergic receptor (beta2AR) variants based on their signaling profiles.
We found that polymorphic Arg16Gly in the ADRB2 gene and Ala54Thr in the FABP2 (show FABP2 Proteins) gene had a discernible effect on the renal function in Chinese type 2 DN. Our data further revealed that homozygous Gly16 allele and Thr54 allele concomitantly conferred a significantly higher risk in the eGFR (show EGFR Proteins) reduction.
decreased beta2AR functionality in patients with OA and LC was independent of patient's beta2AR genotype.
Phosphorylation of the C-terminal region of ADRB2 allosterically alters the conformation around M215(5.54) and M279(6.41), located on transemembrane helices 5 and 6.
Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2.
The Galphas (show GNAS Proteins) and Galphaq (show GNAQ Proteins) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Proteins), respectively. The beta2-AR/Galphas (show GNAS Proteins) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Proteins)/Galphaq (show GNAQ Proteins) peptide interactions are predominantly hydrophobic.
A persistent B2R (show BDKRB2 Proteins)-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA (show PLAT Proteins).
Prolactin (show PRL Proteins) infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway
Intracoronary intermedin (show ADM2 Proteins) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (show CALCA Proteins) receptors and beta-adrenoreceptor-mediated nitric oxide release.
The results imply ADRB-2-mediated actions in the development of primate follicles
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
adrenergic receptor beta-2
, adrenergic, beta-2-, receptor, surface
, beta-2 adrenergic receptor
, beta-2b-adrenergic receptor
, beta-2 adrenoceptor
, beta-2 adrenoreceptor
, beta 2-AR
, adrenergic receptor beta 2
, adrenergic, beta-2, receptor, surface
, catecholamine receptor
, beta2-adrenergic receptor
, Adrenergic beta 2- receptor surface
, adrenergic receptor, beta 2
, Beta-2 adrenergic receptor
, Beta-2 adrenoceptor
, Beta-2 adrenoreceptor
, beta 2 adrenergic receptor
, beta-2-adrenergic receptor