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anti-Human CACNB4 Antibodies:
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Human Polyclonal CACNB4 Primary Antibody for ELISA, WB - ABIN188690
Escayg, Jones, Kearney, Hitchcock, Meisler: Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. in Genomics 1999
Human Polyclonal CACNB4 Primary Antibody for ELISA, WB - ABIN547378
Badou, Basavappa, Desai, Peng, Matza, Mehal, Kaczmarek, Boulpaep, Flavell: Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. in Science (New York, N.Y.) 2005
The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated.
Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy.
Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy
The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif.
CACNB4 is associated with acute lung injury in mice
The novel nucleotide substitution T87C (D29D)in CACNB4 was observed in 2 migrainous vertigo patients and was not present in control DNA samples.
No pathogenic mutation were identified in CACNB4.
plays a role in neurotransmitter release.
proband identified with severe myoclonic epilepsy in infancy heterozygous for de novo SCN1A nonsense mutation & CACNB4 missense mutation (R468Q); greater Ca(v)2.1 currents caused by the mutation may increase neurotransmitter release in excitatory neurons
Study demonstrates that the lack of the voltage-gated calcium channel beta4 subunit causes a decreased late development in cerebellar cortical networks, characterized by reduced parallel fibre-purkinje cell input, shorter purkinje cell dendrites and depressed purkinje cell output.
an alternatively spliced beta4 subunit of voltage-gated calcium channels lacking the variable N terminus (beta4e) is identified
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
Cacnb4 is associated with acute lung injury
neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties
analysis of calcium channel beta4b subunit nuclear targeting in nerve and muscle cells
Paroxysmal dyskinesias as well as absence epilepsy, chronic ataxia, and hypoactivity noted in the lethargic mouse mutant with CCHB4 gene mutation
L-type calcium channel beta 2 and 4 subunits may play a major role in conferring calcium handling heterogeneity within the developing embryonic myocardium
CACNB4 has a role in initiation of zebrafish epiboly
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.
calcium channel voltage-dependent subunit beta 4
, dihydropyridine-sensitive L-type, calcium channel beta-4 subunit
, voltage-dependent L-type calcium channel subunit beta-4
, calcium channel beta 4 subunit
, voltage-dependent calcium channel beta 4 subunit
, calcium channel, voltage-dependent, beta 4 subunit
, voltage-gated calcium channel beta 4.1 subunit
, voltage-dependent L-type calcium channel subunit beta-4-like
, voltage-dependent calcium channel beta 4a subunit
, voltage-gated calcium channel beta-4.2