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Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
Data suggest that Cys3602 in RyR2 (ryanodine receptor 2) plays important role in activation/termination of Ca2+ release, but it is not essential for calmodulin regulation of RyR2.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons.
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
Using mass spectrometry this study identified calmodulin as a calcium-dependent GluN2A (show GRIN2A Proteins) binding partner.
new insights into the role of BTK (show BTK Proteins), an important target for autoimmune diseases, in B cell activation (show BLNK Proteins)
The relationships between the interaction of alphaCaMKII with CaM and the conformational change of alphaCaMKII, were investigated.
the conformational changes of calmodulin (show KRIT1 Proteins) upon Ca(2 (show CA2 Proteins)+) and mastoparan binding
MLCK and calmodulin (CaM) co-purify with unphosphorylated SMM from chicken gizzard, suggesting that they are tightly bound.
Systematic review and meta-analysis of 5 case-control studies involving 2183 osteoarthritis patients 2654 healthy control subjects did not find association between the disease and the rs12885713 polymorphism of CALM1.
We demonstrate that under these conditions the TRPV5 (show TRPV5 Proteins) C-terminus is exclusively bound to the CaM C-lobe only, while it confers conformational freedom to the CaM N-lobe (show LTF Proteins). We also show that at elevated calcium levels, additional interactions between the TRPV5 (show TRPV5 Proteins) C-terminus and CaM N-lobe (show LTF Proteins) occur, resulting in formation of a tight 1:1 complex, effectively making the N-lobe (show LTF Proteins) the calcium sensor.
we present a model for TRPV6 (show TRPV6 Proteins) CaM-dependent inactivation, which involves a novel so-called "two-tail" mechanism whereby CaM bridges two TRPV6 (show TRPV6 Proteins) monomers resulting in closure of the channel pore.
The conservation of homologous residues in helix B of other Kv7 subtypes confer similar competition of Ca(2+)-calmodulin (CaM) with PIP2 binding to their proximal C-termini and suggest that PIP2-CaM interactions converge to Kv7 helix B to modulates channel activity in a Kv7 subtype-dependent manner.
This review provides an overview over our present knowledge concerning the structural and functional aspects of the role of CaM as an adaptor protein and as a regulator of known adaptor/scaffold proteins
Our up-to-date review discusses CaM's role in PI3K signaling at the membrane in KRAS-driven cancers. This is significant since it may help development of K-Ras-specific pharmacology.
Calmodulin is up-regulated and can serve as the potential serum biomarker for predicting the recurrence of nasopharyngeal carcinoma.
cSH2 domain of p85alpha engages its two CaM-binding motifs in the interaction with the N- and C-lobes of CaM as well as the flexible central linker, and our nuclear magnetic resonance experiments provide structural details.
The dynamics of calmodulin interactions with neurogranin (show NRGN Proteins) and Ca(2 (show CA2 Proteins)+) /CAMKII (show CAMK2G Proteins) alpha proteins has been reported.
our work reveals a novel model by which CaM promotes cell migration through inhibiting the ubiquitination and degradation of TBC1D3 (show TBC1D3 Proteins).
analysis of CaM docked to a functioning KCNQ K(+) channel (KCNQ2 and KCNQ3) [KCNQ2, KCNQ3]
Asp-CaM complex has a critical role in centrosome-pole cohesion and centrosome inheritance in neural stem cells
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
characterized the interdomain motions in the calcium-bound state of calmodulin (Ca(2+)-CaM) using NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations
Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V (show MYO5A Proteins).
null behavioral phenotype originates in the nervous system and involves a calmodulin function that requires calcium binding to all four sites of the protein
the direct interaction of melatonin with intact calcium-saturated CaM is calcium-dependent; Molecular dynamics simulations follow the dynamics of melatonin in the binding pocket of CaM
potential functional role for calmodulin in regulation of the glycolytic pathway
A mutation to the gene encoding calmodulin deregulates muscle contraction.
Drosophila CaM is able to fully activate inducible nitric oxide synthase (iNOS (show NOS2 Proteins)); moreover, iNOS (show NOS2 Proteins) activation by CaM, like neuronal NOS (show NOS1 Proteins), is not dependent on Ca2 (show CA2 Proteins)+ being bound to all four Ca2 (show CA2 Proteins)+-binding sites, but has specific and distinct requirements.
Calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2 (show CA2 Proteins)+)-stimulating G protein-coupled receptor (show GPBAR1 Proteins), which could prevent cell damage due to extra Ca(2 (show CA2 Proteins)+) influx.
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
, Calmodulin 1 (phosphorylase kinase, delta)
, calmodulin 1 (phosphorylase kinase, delta)
, phosphorylase kinase subunit delta
, phosphorylase kinase, delta subunit
, prepro-calmodulin 1
, Calmodulin-2 A
, Calmodulin-2 B
, CG8472 gene product from transcript CG8472-RC