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Human CCR2 Protein expressed in Wheat germ - ABIN1329948
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
beta-arrestin2/AP-1-dependent beta2AR signaling has a critical role in the regulation of CCR2 expression and recruitment of leukocytes to the heart following injury
Results indicated that MCP-1 and CCR2 polymorphisms may influence the progression of IgAN, but not increase/decrease its susceptibility
High CCR2 expression is associated gastric cancer.
Our data strongly support the use of CCR2 and CD180 (show CD180 Proteins) mRNAs as whole blood pharmacodynamic (PD)biomarkers for BRD4 (show BRD4 Proteins) inhibitors, especially in situations where paired tumor biopsies are unavailable. In addition, they can be used as tumor-based PD biomarkers for hematologic tumors.
Through experiments with chimeras of MCP-1 and MCP-3, we identified the chemokine amino-terminal region as being the primary determinant of both the binding and signaling selectivity of these two chemokines at CCR2.
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate Gene for Celiac Disease Pathogenesis
Studies indicate manipulating CCL2-CCR2 interaction as a potential approach for combating metastatic disease.
Interruption of either CCL2 (show CCL2 Proteins)-CCR2 signaling or cathepsin B (show CTSB Proteins) function significantly impaired perineural invasion (PNI (show SERPINE2 Proteins)).
No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism with colorectal cancer prevalence
CCR2 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits.
Although CCR2 and CX3CR1 (show CX3CR1 Proteins) may synergistically impact inflammatory phenotypes, their joint deficiency did not influence the metabolic effects of a 45% high-fat diet-induced obesity in these model conditions.
Chemokine receptor 2 (CCR2(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (show CD3E Proteins)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (show CCL1 Proteins) CCL2 (show CCL2 Proteins), a ligand for CCR2, included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta (show IL1B Proteins) was greater in FACS-isolated microglia than in brain-invading monocytes
TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice.
Suggest role for CCR2 expression in podocytes to mediate diabetic renal injury, independent of monocyte/macrophage recruitment.
CCL2 recruits T cells into the brain in a CCR2-independent manner.
in vitro and in vivo results show that CCR2 intrinsically mediates the expression of inflammatory T cell cytokines, and its absence on T cells results in attenuated colitis progression
tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment
CCR2 expression on bone marrow-derived cells, likely macrophages, is essential to muscle regeneration independent of TLR signaling, aging, and sex.
we demonstrated that CX3CR1 (show CX3CR1 Proteins)(Lo)CCR2(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1 (show CX3CR1 Proteins)(Hi)CCR2(Lo) macrophages and CX3CR1 (show CX3CR1 Proteins)(Hi)CCR2(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (show CCNA1 Proteins) population, with resident microglia accounting for the approximately 15% remaining.
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
C-C chemokine receptor type 2
, MCP-1 receptor
, monocyte chemoattractant protein 1 receptor
, monocyte chemotactic protein 1 receptor
, C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
, C-C CKR-2
, JE/FIC receptor
, MIP-1 alphaR
, chemoattractant protein-1 receptor
, chemokine (C-C) receptor 2
, chemokine receptor CCR2
, chemokine receptor