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Human CCR2 Protein expressed in Wheat germ - ABIN1329948
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
T cell-stimulated CLL cells actively recruited monocytes; recruitment critically depended on the C-C-motif-chemokine-receptor-2 axis.
Study found that the activation of CCR2 by its ligand CCL2 (show CCL2 Proteins) increased the expression of SMO and Gli-1 (show GLI1 Proteins), resulting in Hh pathway activation, epithelial-mesenchymal transition and hepatocellular carcinoma cell invasion.
results confirmed that the CCR2 3'UTR acts as a metastasis suppressor by acting as a ceRNA for STARD13 and thus inhibiting RhoA-ROCK1-MLC-F-actin pathway in breast cancer cells.
It can be concluded that MCP-1 and CCR2 polymorphisms are not associated with AgP in Turkish population.
beta-arrestin2/AP-1-dependent beta2AR signaling has a critical role in the regulation of CCR2 expression and recruitment of leukocytes to the heart following injury
Results indicated that MCP-1 and CCR2 polymorphisms may influence the progression of IgAN, but not increase/decrease its susceptibility
High CCR2 expression is associated gastric cancer.
Our data strongly support the use of CCR2 and CD180 (show CD180 Proteins) mRNAs as whole blood pharmacodynamic (PD)biomarkers for BRD4 (show BRD4 Proteins) inhibitors, especially in situations where paired tumor biopsies are unavailable. In addition, they can be used as tumor-based PD biomarkers for hematologic tumors.
Through experiments with chimeras of MCP-1 and MCP-3, we identified the chemokine amino-terminal region as being the primary determinant of both the binding and signaling selectivity of these two chemokines at CCR2.
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate Gene for Celiac Disease Pathogenesis
Using the Theiler's virus model of encephalitis in C57BL/6 mice study shows that CCR2 as well as CX3CR1 (show CX3CR1 Proteins) plays a key role in the accumulation of myeloid cells in the CNS and activation of hippocampal myeloid cells upon infection.
Enhanced bacterial clearance in CCR2(-/-) mice correlated with reduced numbers of IMs in spleens and increased numbers of neutrophils in livers.
Inflammatory CCR2(+) cells that reach the injured kidney at initial stages.
ANG II is up-regulated in serum and heart tissues of mice with EAM and that ANG II significantly drives monocyte/macrophage infiltration through the C-C chemokine receptor 2/5 (CCR2/5) axis.
this study shows that CCR-2/TLR-2 triggered signaling in murine peritoneal macrophages intensifies bacterial (Staphylococcus aureus) killing by reactive oxygen species through TNF-R1 (show TNFRSF1A Proteins)
this paper shows CCR2(-) and CCR2(+) corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion
this study shows that the chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis
Although CCR2 and CX3CR1 (show CX3CR1 Proteins) may synergistically impact inflammatory phenotypes, their joint deficiency did not influence the metabolic effects of a 45% high-fat diet-induced obesity in these model conditions.
Chemokine receptor 2 (CCR2(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (show CD3E Proteins)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (show CCL1 Proteins) CCL2 (show CCL2 Proteins), a ligand for CCR2, included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta (show IL1B Proteins) was greater in FACS-isolated microglia than in brain-invading monocytes
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
C-C chemokine receptor type 2
, MCP-1 receptor
, monocyte chemoattractant protein 1 receptor
, monocyte chemotactic protein 1 receptor
, C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
, C-C CKR-2
, JE/FIC receptor
, MIP-1 alphaR
, chemoattractant protein-1 receptor
, chemokine (C-C) receptor 2
, chemokine receptor CCR2
, chemokine receptor