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Human CXCR2 Protein expressed in Wheat germ - ABIN1330037
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
Human CXCR2 Protein expressed in Escherichia coli (E. coli) - ABIN4988970
Zhang, Ling, Pang, Wang, Liu, Wang, Liang, Guo, Qin, Wang: Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles. in Theranostics 2017
CXCR2 was a direct target of microRNA (miR)-4437, a negative regulator of CXCR2, which was downregulated in peripheral leucocytes from patients with ischemic stroke.
CXCR2 pathway is instrumental in the anti-angiogenic therapy-mediated resistance and vascular mimicry formation in glioblastoma.
Both GRO-alpha and IL-8 can activate TAK1/NFkappaB signaling via the CXCR2 receptor.
These results suggest a direct involvement of IL-8-CXCR1/2 axes in GBM progression by promoting both cell proliferation and invasion and indirectly by promoting neovascularization in the form of vascular mimicry.
These data were in close agreement with the reduced cell migration and colony formation. Results from the present study suggested that reparixin and SCH527123 may be promising therapeutic agents for the treatment of pancreatic cancer by inhibiting the IL8/CXCR1/2 signaling cascade.
The CXCR2 rs1126579 TT genotype had a significantly increased possibility of HCV spontaneous clearance.
increased production of IL-8 associated with neutrophils infiltration into the liver and decreased CXCR1/2 expression on peripheral neutrophils. CXCR1 and CXCR2 expression levels could be served as early markers to predict the severity of acute-on-chronic liver failure.
CXCR2 protein expression was up-regulated in both the epileptic foci of temporal lobe epilepsy patients and in the pilocarpine mouse model. The CXCR2 selective antagonist SB225002, which was i.p. administered during the spontaneous recurrent seizures (SRSs) latency window preceding SRS onset, suppressed SRSs activity during the chronic period of epilepsy.
inflammation triggered property of Microcystin-LR via IL-8/CXCR2 signaling
results indicated that the CXCR2 +1208 CT genotype is less frequent in advanced stages of prostate cancer, suggesting that this chemokine receptor plays a role in the pathogenesis of this disease
CXCR2 expression is a promoter of CRC local as well as distant metastasis and unfavorably associated with CRC patients' prognosis. Moreover, CXCR2 can stratify high-risk patients especially in normally early stage low-risk CRC patients.
PADI4 contributes to gastric tumorigenesis by upregulating CXCR2, KRT14 and TNF-alpha expression.
Association of polymorphic markers of chemokine genes, their receptors, and CD14 gene with coronary atherosclerosis
In this review, we summarize the biological functions and clinical significance of the CXCL8-CXCR1/2 signaling pathway in cancer. Targeting CXCL8 or CXCR1/2 may be an attractive therapeutic strategy for tumors.
KHSV miR-K3 activates the GRK2/CXCR2/AKT axis inducing KSHV-induced angiogenesis and promoting KSHV latency.
CXCR2 mRNA and protein expression levels were significantly decreased in preeclamptic placentas than normal control. The invasive abilities of the two trophoblast cell lines were significantly inhibited when CXCR2 was silenced, but that CXCR2 overexpression promoted trophoblast cells invasion.
CXCR2 promotes breast cancer metastasis and chemoresistance via suppressing AKT1 and activating COX2.
we conclude that CXCR2 is required for the recruitment of TANs, which in turn can suppress antitumor T-cell responses. We showed that CXCR2 ligands, particularly CXCL5, are elevated in both human and mouse PDA.
this study shows that neutrophil expression levels of CVCR2 are decreased in septic patients
CXCR4 and CXCR2 were highly expressed in a high invasive gastric cancer cell model and in gastric cancer tissues; crosstalk between CXCR4 and CXCR2 contributed to EMT, migration and invasion of gastric cancer.
Results also demonstrated that in CXCR2, genotypes BC, CC and FF were probably relevant with mastitis and the genotypes AA, AB and EE may have better milk quality.
Role of CXCR2 in the control of infection, hypernociception and tissue damage in S. aureus-induced septic arthritis. The kinetics of neutrophil recruitment correlated with the bacterial load recovered from inflamed joints after intra-articular injection of S. aureus.
Only band III granulocyte myeloid-derived suppressor cells (G-MDSCs) display significant expansion in B16 melanoma, Lewis lung carcinoma, or MC38 colon carcinoma. The expanded G-MDSCs also show increased CXCR2 expression.
TIARP independently down-regulated CXCL2 and IL-6 production by fibroblast-like synoviocytes, and the expression of chemokine receptors (CXCR1 and CXCR2) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints.
these data provide novel insight into a dynamic IL-17A-CXCR2-neutrophil axis during acute segmented filamentous bacteria colonization and demonstrate a central role for neutrophils in limiting segmented filamentous bacteria expansion
Combining CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
Results demonstrated that complete Freund's adjuvant increased CXCL1 and CXCR2 expression in the dorsal root ganglion, with the cellular distribution in all sizes neurons. In addition, specific inhibition of CXCR2 in the dorsal root ganglion attenuated established inflammatory pain.
postnatal development of the intestinal microbiota is an important susceptibility factor for experimental biliary atresia, which involves Cxcr2 signaling
this study demonstrates CXCR2-driven activation of NLRP3 inflammasome in macrophages, and indicates a potential host-directed therapeutic target to limit the damaging inflammation associated with overt production of proinflammatory IL-1beta
upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
RelA has a role in regulating OIS in preneoplastic lesions; the RelA/CXCL1/CXCR2 axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma
TNFalpha-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting
These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.
the results of this study indicate a new potential use for gastrin-releasing peptide receptor antagonist for treatment of drug-induced liver injury through a mechanism involving adhesion molecule modulation and possible direct binding to CXCR2
this study shows that astragaloside IV alleviates E. coli-caused peritonitis through modulating GRK2-CXCR2 signal in neutrophils
Study shows that CXCR2 signaling in the myeloid compartment is tumor promoting and required for pancreatic cancer metastasis.
CXCR2/CXCL1 axis promotes granulocytic myeloid-derived suppressor cells recruitment and facilitates arginase I expression and activity of these cells at maternal-fetal interface
CXCR2 plays a critical role in particle-induced osteolysis.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
C-X-C chemokine receptor type 2
, interleukin 8 receptor beta
, interleukin-8 receptor CXCR2
, CXCR2 gene for IL8 receptor type B
, GRO/MGSA receptor
, IL-8 receptor type 2
, IL-8R B
, chemokine (CXC) receptor 2
, high affinity interleukin-8 receptor B
, interleukin 8 receptor B
, interleukin 8 receptor type 2
, interleukin 8 receptor, beta
, interleukin-8 receptor type B
, chemokine receptor CXCR2
, interleukin 8 receptor, alpha
, IL-8 receptor alpha chain
, chemokine (C-X-C) receptor 2
, IL-8 receptor
, High affinity interleukin-8 receptor B
, interleukin-8 receptor, beta