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Human CXCR2 Protein expressed in Wheat germ - ABIN1330037
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
Human CXCR2 Protein expressed in Escherichia coli (E. coli) - ABIN4988970
Zhang, Ling, Pang, Wang, Liu, Wang, Liang, Guo, Qin, Wang: Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles. in Theranostics 2017
These data were in close agreement with the reduced cell migration and colony formation. Results from the present study suggested that reparixin and SCH527123 may be promising therapeutic agents for the treatment of pancreatic cancer by inhibiting the IL8 (show IL8 Proteins)/CXCR1 (show CXCR1 Proteins)/2 signaling cascade.
The CXCR2 rs1126579 TT genotype had a significantly increased possibility of HCV spontaneous clearance.
increased production of IL-8 (show IL8 Proteins) associated with neutrophils infiltration into the liver and decreased CXCR1 (show CXCR1 Proteins)/2 expression on peripheral neutrophils. CXCR1 (show CXCR1 Proteins) and CXCR2 expression levels could be served as early markers to predict the severity of acute-on-chronic liver failure.
CXCR2 protein expression was up-regulated in both the epileptic foci of temporal lobe epilepsy patients and in the pilocarpine mouse model. The CXCR2 selective antagonist SB225002, which was i.p. administered during the spontaneous recurrent seizures (SRSs) latency window preceding SRS (show SMS Proteins) onset, suppressed SRSs activity during the chronic period of epilepsy.
inflammation triggered property of Microcystin-LR via IL-8 (show IL8 Proteins)/CXCR2 signaling
results indicated that the CXCR2 +1208 CT genotype is less frequent in advanced stages of prostate cancer, suggesting that this chemokine receptor plays a role in the pathogenesis of this disease
CXCR2 expression is a promoter of CRC (show CALR Proteins) local as well as distant metastasis and unfavorably associated with CRC (show CALR Proteins) patients' prognosis. Moreover, CXCR2 can stratify high-risk patients especially in normally early stage low-risk CRC (show CALR Proteins) patients.
PADI4 (show PADI4 Proteins) contributes to gastric tumorigenesis by upregulating CXCR2, KRT14 (show KRT14 Proteins) and TNF-alpha (show TNF Proteins) expression.
Association of polymorphic markers of chemokine (show CCL1 Proteins) genes, their receptors, and CD14 (show NDUFA2 Proteins) gene with coronary atherosclerosis
In this review, we summarize the biological functions and clinical significance of the CXCL8 (show IL8 Proteins)-CXCR1 (show CXCR1 Proteins)/2 signaling pathway in cancer. Targeting CXCL8 (show IL8 Proteins) or CXCR1 (show CXCR1 Proteins)/2 may be an attractive therapeutic strategy for tumors.
Results also demonstrated that in CXCR2 (show CXCR1 Proteins), genotypes BC, CC and FF were probably relevant with mastitis and the genotypes AA, AB and EE may have better milk quality.
TIARP (show STEAP4 Proteins) independently down-regulated CXCL2 (show CXCL2 Proteins) and IL-6 (show IL6 Proteins) production by fibroblast-like synoviocytes, and the expression of chemokine (show CCL1 Proteins) receptors (CXCR1 (show CXCR1 Proteins) and CXCR2) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints.
CXCR2 protein expression was up-regulated in both the epileptic foci of temporal lobe epilepsy patients and in the pilocarpine mouse model. The CXCR2 selective antagonist SB225002, which was i.p. administered during the spontaneous recurrent seizures (SRSs) latency window preceding SRS (show SRR Proteins) onset, suppressed SRSs activity during the chronic period of epilepsy.
these data provide novel insight into a dynamic IL-17A (show IL17A Proteins)-CXCR2-neutrophil axis during acute segmented filamentous bacteria colonization and demonstrate a central role for neutrophils in limiting segmented filamentous bacteria expansion
Combining CSF1R (show CSF1R Proteins) inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
we conclude that CXCR2 is required for the recruitment of TANs, which in turn can suppress antitumor T-cell responses. We showed that CXCR2 ligands, particularly CXCL5 (show CXCL5 Proteins), are elevated in both human and mouse PDA.
Results demonstrated that complete Freund's adjuvant increased CXCL1 (show CXCL1 Proteins) and CXCR2 expression in the dorsal root ganglion, with the cellular distribution in all sizes neurons. In addition, specific inhibition of CXCR2 in the dorsal root ganglion attenuated established inflammatory pain.
postnatal development of the intestinal microbiota is an important susceptibility factor for experimental biliary atresia, which involves Cxcr2 signaling
this study demonstrates CXCR2-driven activation of NLRP3 (show NLRP3 Proteins) inflammasome in macrophages, and indicates a potential host-directed therapeutic target to limit the damaging inflammation associated with overt production of proinflammatory IL-1beta (show IL1B Proteins)
upregulation of CCRL2 (show CCRL2 Proteins) observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
C-X-C chemokine receptor type 2
, interleukin 8 receptor beta
, interleukin-8 receptor CXCR2
, CXCR2 gene for IL8 receptor type B
, GRO/MGSA receptor
, IL-8 receptor type 2
, IL-8R B
, chemokine (CXC) receptor 2
, high affinity interleukin-8 receptor B
, interleukin 8 receptor B
, interleukin 8 receptor type 2
, interleukin 8 receptor, beta
, interleukin-8 receptor type B
, chemokine receptor CXCR2
, interleukin 8 receptor, alpha
, IL-8 receptor alpha chain
, chemokine (C-X-C) receptor 2
, IL-8 receptor
, High affinity interleukin-8 receptor B
, interleukin-8 receptor, beta