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Human CXCR2 Protein expressed in Wheat germ - ABIN1330037
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
CXCR4 (show CXCR4 Proteins) and CXCR2 were highly expressed in a high invasive gastric cancer cell model and in gastric cancer tissues; crosstalk between CXCR4 (show CXCR4 Proteins) and CXCR2 contributed to EMT (show ITK Proteins), migration and invasion of gastric cancer.
A unique viral protein, vCXCL1, which targets three chemokine (show CCL1 Proteins) receptors: CXCR1 (show CXCR1 Proteins) and CXCR2 expressed on neutrophils and CXCR1 (show CXCR1 Proteins) and CX3CR1 (show CX3CR1 Proteins) expressed on Natural killer cells.
The expressions of CXCL1 (show CXCL1 Proteins) in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients
CXCR2 preferentially supports the maintenance of human pluripotent stem cell characteristics as well as facilitates ectodermal differentiation after the commitment to differentiation, and the mechanism might be associated with mTOR (show FRAP1 Proteins), beta-catenin (show CTNNB1 Proteins), and hTERT activities.
Our result showed that CXCR2 expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 and CXCR3 (show CXCR3 Proteins) expressions are related to poorer overall survival (P < 0.001; P < 0.001).
These data demonstrate that the CXCR2 network and CXCL4 (show PF4 Proteins) play a role in the maintenance of normal HSC (show FUT1 Proteins)/HPC cell fates, including survival and self-renewal.
CXCR1 (show CXCR1 Proteins) and CXCR2 regulate hepatocyte exosome release. The mechanism utilized by CXCR1 (show CXCR1 Proteins) remains elusive, but CXCR2 appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 (show CXCR1 Proteins) is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect.
TNF-alpha (show TNF Proteins) augments CXCR2 and CXCR3 (show CXCR3 Proteins) to promote the progression of renal cell carcinoma (show MOK Proteins) leading to a poor prognosis.
Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif.
Treatment with 1,25D3 increased poly(I:C)-induced IL-8 (show IL8 Proteins) mRNA and protein expression after 2 to 6 hours. However, when cells were pretreated with 1,25D3 for 24 hours, 1,25D3 decreased cytokine expression
Results also demonstrated that in CXCR2 (show CXCR1 Proteins), genotypes BC, CC and FF were probably relevant with mastitis and the genotypes AA, AB and EE may have better milk quality.
Results demonstrated that complete Freund's adjuvant increased CXCL1 (show CXCL1 Proteins) and CXCR2 expression in the dorsal root ganglion, with the cellular distribution in all sizes neurons. In addition, specific inhibition of CXCR2 in the dorsal root ganglion attenuated established inflammatory pain.
postnatal development of the intestinal microbiota is an important susceptibility factor for experimental biliary atresia, which involves Cxcr2 signaling
this study demonstrates CXCR2-driven activation of NLRP3 (show NLRP3 Proteins) inflammasome in macrophages, and indicates a potential host-directed therapeutic target to limit the damaging inflammation associated with overt production of proinflammatory IL-1beta (show IL1B Proteins)
upregulation of CCRL2 (show CCRL2 Proteins) observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
RelA (show NFkBP65 Proteins) has a role in regulating OIS in preneoplastic lesions; the RelA (show NFkBP65 Proteins)/CXCL1 (show CXCL1 Proteins)/CXCR2 axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma
TNFalpha (show TNF Proteins)-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting
the results of this study indicate a new potential use for gastrin-releasing peptide receptor (show GRPR Proteins) antagonist for treatment of drug-induced liver injury through a mechanism involving adhesion molecule (show NCAM1 Proteins) modulation and possible direct binding to CXCR2
this study shows that astragaloside IV alleviates E. coli-caused peritonitis through modulating GRK2 (show ADRBK1 Proteins)-CXCR2 signal in neutrophils
Study shows that CXCR2 signaling in the myeloid compartment is tumor promoting and required for pancreatic cancer metastasis.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
C-X-C chemokine receptor type 2
, interleukin 8 receptor beta
, interleukin-8 receptor CXCR2
, CXCR2 gene for IL8 receptor type B
, GRO/MGSA receptor
, IL-8 receptor type 2
, IL-8R B
, chemokine (CXC) receptor 2
, high affinity interleukin-8 receptor B
, interleukin 8 receptor B
, interleukin 8 receptor type 2
, interleukin 8 receptor, beta
, interleukin-8 receptor type B
, chemokine receptor CXCR2
, interleukin 8 receptor, alpha
, IL-8 receptor alpha chain
, chemokine (C-X-C) receptor 2
, IL-8 receptor
, High affinity interleukin-8 receptor B
, interleukin-8 receptor, beta