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Human CXCR2 Protein expressed in Wheat germ - ABIN1330037
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
PADI4 (show PADI4 Proteins) contributes to gastric tumorigenesis by upregulating CXCR2, KRT14 (show KRT14 Proteins) and TNF-alpha (show TNF Proteins) expression.
Association of polymorphic markers of chemokine (show CCL1 Proteins) genes, their receptors, and CD14 (show NDUFA2 Proteins) gene with coronary atherosclerosis
In this review, we summarize the biological functions and clinical significance of the CXCL8 (show IL8 Proteins)-CXCR1 (show CXCR1 Proteins)/2 signaling pathway in cancer. Targeting CXCL8 (show IL8 Proteins) or CXCR1 (show CXCR1 Proteins)/2 may be an attractive therapeutic strategy for tumors.
KHSV miR (show MLXIP Proteins)-K3 activates the GRK2 (show ADRBK1 Proteins)/CXCR2/AKT (show AKT1 Proteins) axis inducing KSHV-induced angiogenesis and promoting KSHV latency.
CXCR2 mRNA and protein expression levels were significantly decreased in preeclamptic placentas than normal control. The invasive abilities of the two trophoblast cell lines were significantly inhibited when CXCR2 was silenced, but that CXCR2 overexpression promoted trophoblast cells invasion.
CXCR2 promotes breast cancer metastasis and chemoresistance via suppressing AKT1 (show AKT1 Proteins) and activating COX2.
we conclude that CXCR2 is required for the recruitment of TANs, which in turn can suppress antitumor T-cell responses. We showed that CXCR2 ligands, particularly CXCL5 (show CXCL5 Proteins), are elevated in both human and mouse PDA.
CXCR4 (show CXCR4 Proteins) and CXCR2 were highly expressed in a high invasive gastric cancer cell model and in gastric cancer tissues; crosstalk between CXCR4 (show CXCR4 Proteins) and CXCR2 contributed to EMT (show ITK Proteins), migration and invasion of gastric cancer.
A unique viral protein, vCXCL1, which targets three chemokine (show CCL1 Proteins) receptors: CXCR1 (show CXCR1 Proteins) and CXCR2 expressed on neutrophils and CXCR1 (show CXCR1 Proteins) and CX3CR1 (show CX3CR1 Proteins) expressed on Natural killer cells.
The expressions of CXCL1 (show CXCL1 Proteins) in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients
Results also demonstrated that in CXCR2 (show CXCR1 Proteins), genotypes BC, CC and FF were probably relevant with mastitis and the genotypes AA, AB and EE may have better milk quality.
these data provide novel insight into a dynamic IL-17A (show IL17A Proteins)-CXCR2-neutrophil axis during acute segmented filamentous bacteria colonization and demonstrate a central role for neutrophils in limiting segmented filamentous bacteria expansion
Combining CSF1R (show CSF1R Proteins) inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
Results demonstrated that complete Freund's adjuvant increased CXCL1 (show CXCL1 Proteins) and CXCR2 expression in the dorsal root ganglion, with the cellular distribution in all sizes neurons. In addition, specific inhibition of CXCR2 in the dorsal root ganglion attenuated established inflammatory pain.
postnatal development of the intestinal microbiota is an important susceptibility factor for experimental biliary atresia, which involves Cxcr2 signaling
this study demonstrates CXCR2-driven activation of NLRP3 (show NLRP3 Proteins) inflammasome in macrophages, and indicates a potential host-directed therapeutic target to limit the damaging inflammation associated with overt production of proinflammatory IL-1beta (show IL1B Proteins)
upregulation of CCRL2 (show CCRL2 Proteins) observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
RelA (show NFkBP65 Proteins) has a role in regulating OIS in preneoplastic lesions; the RelA (show NFkBP65 Proteins)/CXCL1 (show CXCL1 Proteins)/CXCR2 axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma
TNFalpha (show TNF Proteins)-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting
These data demonstrate that the CXCR2 network and CXCL4 (show PF4 Proteins) play a role in the maintenance of normal HSC (show FUT1 Proteins)/HPC cell fates, including survival and self-renewal.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
C-X-C chemokine receptor type 2
, interleukin 8 receptor beta
, interleukin-8 receptor CXCR2
, CXCR2 gene for IL8 receptor type B
, GRO/MGSA receptor
, IL-8 receptor type 2
, IL-8R B
, chemokine (CXC) receptor 2
, high affinity interleukin-8 receptor B
, interleukin 8 receptor B
, interleukin 8 receptor type 2
, interleukin 8 receptor, beta
, interleukin-8 receptor type B
, chemokine receptor CXCR2
, interleukin 8 receptor, alpha
, IL-8 receptor alpha chain
, chemokine (C-X-C) receptor 2
, IL-8 receptor
, High affinity interleukin-8 receptor B
, interleukin-8 receptor, beta