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In conclusion, Galphai2 deficiency in erythrocytes confers partial protection against suicidal cell death.
This study reveals how RGS (show PITX2 Proteins) proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.
this study shows that Galphai2 controls arrest in response to chemokine (show CCL1 Proteins) stimulation of neutrophils
In Galphai2-knockdown mice, they showed defects in social interaction, novelty recognition and active avoidance learning.
Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
RGS (show PITX2 Proteins) proteins and Galphai2 play a significant role in regulating states of wakefulness, NREM sleep, and REM (show REM1 Proteins) sleep
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
An essential role for Galpha (show SUCLG1 Proteins)(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.
The data show that the nonpalmitoylated CB1 (show CNR1 Proteins) receptor significantly reduced its association with Galphai2 .
MicroRNA-222-3p/GNAI2/AKT (show AKT1 Proteins) signaling axis inhibits epithelial ovarian cancer cell growth and is associated with good overall survival.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3 (show GNAI3 Proteins), with no evidence for functional coupling to Galphagust.
Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.
Galpha (show SUCLG1 Proteins)(i2) activates the TRPC4 (show TRPC4 Proteins) channel by direct binding.
Changes in ion selectivity and pore dilation of the TRPC4 (show TRPC4 Proteins) channel elicited by the Galphai2 subunit, were studied.
Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase (show HDAC1 Proteins) -dependent manner
These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 (show CACNA1A Proteins) Ca(2 (show CA2 Proteins)+) channels
The ubiquitination of Galphai2 and Galphaq (show GNAQ Proteins) is suppressed by expression of Ric-8A (show RIC8A Proteins). The suppression likely requires Ric-8A (show RIC8A Proteins) interaction with these Galpha (show SUCLG1 Proteins) proteins; the C-terminal truncation of Galphaq (show GNAQ Proteins) and Galphai2 completely abrogates their interaction with Ric-8A (show RIC8A Proteins).
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 2
, guanine nucleotide-binding protein G(i) subunit alpha-2
, Gi2 protein alpha-subunit
, GTP-binding regulatory protein Gi alpha-2 chain
, guanine nucleotide-binding protein G(i), alpha-2 subunit
, guanine nucleotide-binding regulatory protein alpha inhibitory subunit
, Gi-alpha-2 protein
, guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2
, guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2
, G alpha inhibitory type 2 (a)
, G alpha inhibitory type 2 (b)
, GTP-binding protein (G-alpha-i2)
, guanine nucleotide binding protein (G protein), alpha inhibiting 2
, guanine nucleotide binding protein, alpha inhibiting 3
, Galpha i2a
, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
, guanine nucleotide-binding protein Gi2 alpha-subunit