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These results delineate a role for Galphai2 in early thymocyte development and for Galphai2/3 in multiple aspects of T cell biology.
In conclusion, Galphai2 deficiency in erythrocytes confers partial protection against suicidal cell death.
This study reveals how RGS proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.
this study shows that Galphai2 controls arrest in response to chemokine stimulation of neutrophils
In Galphai2-knockdown mice, they showed defects in social interaction, novelty recognition and active avoidance learning.
Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
RGS proteins and Galphai2 play a significant role in regulating states of wakefulness, NREM sleep, and REM sleep
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
An essential role for Galpha(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A) expression in hematopoietic cells results in a loss of GTP-binding protein alpha subunits Galphai2, Galphai3, and Galphaq.
S1P sensitizes ICAPS through G-protein coupled S1P1 receptor activation of Galphai-PI3K-PKC-p38 signaling pathway in sensory neurons
Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Galphai2 and Galphai3, indicating important roles for both Galphai isoforms.
RGS protein/Galphai2 interactions have an essential role in B lymphocyte-directed cell migration and trafficking.
Data (including data from knockout mice) suggest that Gnai2 in islet beta-cells is necessary for up-regulation of insulin secretion in response to high glucose in presence of L-arginine or L-ornithine.
The absence of Galphai2 and Galphai3 in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract.
Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase -dependent manner
Galphas- and Galphai2-mediated signaling in the sinoatrial node is important in the reciprocal regulation of heart rate through the autonomic nervous system.
Galphai2-deficient mice spontaneously develop colitis and colonic neoplasms the severity of which are determined by the interplay between Th1 and Th2 cell pathways.
3.6 A structure of the human A1R in complex with adenosine and heterotrimeric Gi2 protein determined by Volta phase plate cryo-electron microscopy
The data show that the nonpalmitoylated CB1 receptor significantly reduced its association with Galphai2 .
MicroRNA-222-3p/GNAI2/AKT signaling axis inhibits epithelial ovarian cancer cell growth and is associated with good overall survival.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3, with no evidence for functional coupling to Galphagust.
Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.
Galpha(i2) activates the TRPC4 channel by direct binding.
We observed increased expression of Galphai1/3 in wounded human skin and keloid skin tissues, suggesting the possible involvement of Galphai1/3 in wound healing and keloid formation.
Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 subunit, were studied.
There is an interaction between the activated Gsalpha subunit and membrane lipid microdomains in the pathophysiology of some major depressive disorders.
These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 Ca(2+) channels
The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A.
Gialpha2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration.
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha(i2) for degradation through ubiquitination
Galphai2 as a novel claudin-5 partner required for TJ integrity in brain endothelial cells.
Suggest that Gnia2 is involved in endothelial TLR pathways along a signaling cascade that is distinct from MyD88.
SDF-1 treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2, and ZAP-70.
Study identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in tongue squamous cell carcinoma. initiation and progression.
CXCL12 upregulated T-cell activation, and an alpha(i) G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12.
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 2
, guanine nucleotide-binding protein G(i) subunit alpha-2
, Gi2 protein alpha-subunit
, GTP-binding regulatory protein Gi alpha-2 chain
, guanine nucleotide-binding protein G(i), alpha-2 subunit
, guanine nucleotide-binding regulatory protein alpha inhibitory subunit
, Gi-alpha-2 protein
, guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2
, guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2
, G alpha inhibitory type 2 (a)
, G alpha inhibitory type 2 (b)
, GTP-binding protein (G-alpha-i2)
, guanine nucleotide binding protein (G protein), alpha inhibiting 2
, guanine nucleotide binding protein, alpha inhibiting 3
, Galpha i2a
, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
, guanine nucleotide-binding protein Gi2 alpha-subunit