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anti-Human Mu Opioid Receptor 1 Antibodies:
anti-Mouse (Murine) Mu Opioid Receptor 1 Antibodies:
anti-Rat (Rattus) Mu Opioid Receptor 1 Antibodies:
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Cat (Feline) Polyclonal Mu Opioid Receptor 1 Primary Antibody for IEM, ICC - ABIN617908
Gracy, Svingos, Pickel: Dual ultrastructural localization of mu-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbens. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
Show all 127 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IHC - ABIN966719
Wang, Johnson, Persico, Hawkins, Griffin, Uhl: Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. in FEBS letters 1994
Show all 7 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IHC, IHC (p) - ABIN441215
Dever, Xu, Fitting, Knapp, Hauser: Differential expression and HIV-1 regulation of μ-opioid receptor splice variants across human central nervous system cell types. in Journal of neurovirology 2012
Show all 2 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IF (p), IHC (p) - ABIN701755
Laureano, Dalle Molle, Alves, Luft, Desai, Ross, Silveira: Intrauterine growth restriction modifies the hedonic response to sweet taste in newborn pups - Role of the accumbal μ-opioid receptors. in Neuroscience 2016
Show all 2 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IF (p), IHC (p) - ABIN703210
Brewer, Baran, Whitfield, Jensen, Clemens: Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. in Frontiers in neural circuits 2014
Show all 2 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for ICC, IHC (fro) - ABIN250447
Vassoler, Wright, Byrnes: Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring. in Neuropharmacology 2016
Polyclonal Mu Opioid Receptor 1 Primary Antibody for WB - ABIN4948303
Rodríguez-Muñoz, de la Torre-Madrid, Gaitán, Sánchez-Blázquez, Garzón: RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. in Cellular signalling 2007
Genetic variations in the mu-opioid receptor (OPRM1) gene have been related to high sensitivity to rewarding effects of alcohol.
Findings suggest no OPRM1-based susceptibility to the number of heavy-drinking peers, adding to the existing mixed findings from correlational studies. Future research on OPRM1-related susceptibility to alcohol-promoting peer environments through meta-analytic synthesis and both experimental and prospective, multiwave designs is needed to resolve these mixed findings.
The MDR1 (show TBC1D9 Antibodies)/CYP3A4 (show CYP3A4 Antibodies)/OPRM1 gene polymorphisms influenced the fentanyl consumption and the physiological effects of intravenous analgesia in the Chinese women who received lower segment caesarean section surgeries.
Participants with the OPRM1 118G allele evidenced steeper breath alcohol concentration (BrAC) trajectories and greater peak BrAC relative to 118A homozygous participants. Significant indirect associations of OPRM1 with follow-up heavy drinking were observed.
Study demonstrated in a cohort of 84 cancer patients that high-dose opioid use correlates with OPRM1 hypermethylation in peripheral leukocytes; and showed that targeted re-expression of mu-opioid receptor on cancer cells inhibits mechanical and thermal hypersensitivity, and prevents opioid tolerance, in a mouse cancer pain model. Epigenetic regulation of OPRM1 contributes to opioid tolerance in cancer patients.
In summary, our results suggest that, by genetic association, the mu-opioid receptor interacts with serotonin transporter (show SLC6A4 Antibodies) and serotonin 1A receptor to modulate exercise-induced hypoalgesia in fibromyalgia.
Significant epistatic interactions were determined between OPRM1 and DAT1 genotypes on alcohol consumption and subjective effects in social drinkers.
OPRM1/mu-opioid receptor system was uniformly expressed by epidermal keratinocytes from psoriasis patients and controls.
Morphine-induced MOP receptor endocytosis is facilitated by concurrent M3 activation.M3 and MOP (show NLN Antibodies) assemble in receptor heterocomplexes mainly located at the plasma membrane.M3-MOP receptor pharmacological interaction is independent of heterocomplex formation.M3 and MOP receptor heteromers disrupt upon both receptor endocytosis.
A quantitative trait loci in OPRM1 is associated with alcohol use phenotypes and the subjective response to alcohol.
Suggest that peripheral and central MOR and central KOR (show OPRK1 Antibodies) may be involved in the modulation of scratching behaviour in imiquimod-treated mice.
Results demonstrate that MOR-dependent behavioral effects of BPN including pain sensitivity, locomotor hyperactivity and approach behavior in the NIH test, are modified by genetic variation in the A112G SNP with the A carrier being most responsive to drug effects.
The CeA (show CEA Antibodies) was subsequently targeted with bilateral infusions of the MOR antagonist naloxonazine, which significantly reduced sodium appetite in mice. The CeA (show CEA Antibodies) is therefore identified as a key node in the circuit that contributes to sodium appetite. Moreover, endogenous opioids, acting via MOR, within the CeA (show CEA Antibodies) promote this form of appetitive behavior
Oprm1 knock-out mice lacking 6TM genetic variants failed to show morphine-induced hyperalgesia.
Findings implicate truncated Oprm1 6TM splice variants in analgesic mechanisms and suggest that they may help explain many of the subtle, but important, clinical differences among mu opioids.
The data show that somatic MORs in POMC (show POMC Antibodies) neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
C termini generated from 3' alternative splicing of the mu opioid receptor gene are pharmacologically distinct.
Double mothering normalized the abnormal response to maternal separation in Oprm1-knockout mice, in an animal model of Autism.
OPRM1, expressed by primary afferent nociceptors, initiates opiate tolerance and opioid-induced hyperalgesia development.
Study reveals dissociable Mu opioid receptors (MOR) functions across mesocorticolimbic networks. Beyond a role in reward processing, operating at the level of local ventral tegmental area neurons, MORs also moderate motivation for appetitive stimuli within forebrain circuits that drive motivated behaviors.
MicroRNA miR (show MYLIP Antibodies)-212/132 cluster is actively repressing the expression of mu opioid receptor (Oprm1) by targeting a sequence in the 3' UTR (show UTS2R Antibodies) of its mRNA.
demonstrate that zfMOR exhibits a pharmacological profile similar to that of the mammalian MOR.
A nonsynonymous SNP in the first exon of the OPRM1 gene (OPRM1 A118G) encodes the ligand-binding domain the receptor and which has been associated with increased alcohol-induced stimulation and euphoria.
Coactivation of mu opioid receptors with nociceptin (show PNOC Antibodies) receptors produces synergistic antinociception.
Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.
findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.
micro opioid receptor isoform hMOR-1A2
, mu opiate receptor
, mu opioid receptor hMOR-1a
, mu-type opioid receptor
, MOP receptor
, mu opioid receptor splice variant rMOR-1S
, mu opioid receptor splice variant rMOR-1Z
, opioid receptor B
, opioid receptor, mu 1
, mu opioid receptor
, mu-opioid receptor
, outer membrane protein OprM