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anti-Human Mu Opioid Receptor 1 Antibodies:
anti-Mouse (Murine) Mu Opioid Receptor 1 Antibodies:
anti-Rat (Rattus) Mu Opioid Receptor 1 Antibodies:
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Cat (Feline) Polyclonal Mu Opioid Receptor 1 Primary Antibody for IEM, ICC - ABIN617908
Gracy, Svingos, Pickel: Dual ultrastructural localization of mu-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbens. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
Show all 127 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IHC - ABIN966719
Wang, Johnson, Persico, Hawkins, Griffin, Uhl: Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. in FEBS letters 1994
Show all 7 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IF (p), IHC (p) - ABIN701755
Laureano, Dalle Molle, Alves, Luft, Desai, Ross, Silveira: Intrauterine growth restriction modifies the hedonic response to sweet taste in newborn pups - Role of the accumbal μ-opioid receptors. in Neuroscience 2016
Show all 2 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IF (p), IHC (p) - ABIN703210
Brewer, Baran, Whitfield, Jensen, Clemens: Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. in Frontiers in neural circuits 2014
Show all 2 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for IHC, IHC (p) - ABIN441215
Dever, Xu, Fitting, Knapp, Hauser: Differential expression and HIV-1 regulation of μ-opioid receptor splice variants across human central nervous system cell types. in Journal of neurovirology 2012
Show all 2 Pubmed References
Human Polyclonal Mu Opioid Receptor 1 Primary Antibody for ICC, IHC (fro) - ABIN250447
Vassoler, Wright, Byrnes: Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring. in Neuropharmacology 2016
Polyclonal Mu Opioid Receptor 1 Primary Antibody for WB - ABIN4948303
Rodríguez-Muñoz, de la Torre-Madrid, Gaitán, Sánchez-Blázquez, Garzón: RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. in Cellular signalling 2007
ADRB2 (show ADRB2 Antibodies) gene expressed in HIV-associated neurocognitive impairment and encephalitis chaperones OPRM1, normally located intracellularly in astrocytes, to the cell surface.
These results are in line with previous studies suggesting that mu-opioid receptor signalling has been elaborated beyond its basic function of pain modulation to play an important role in managing our social encounters.
Significant interaction of OPRM1 genotype, binding potential for [(11)C]carfentanil in the ventral striatum, and relapse risk in alcoholics.
Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK (show EPHA3 Antibodies)) cells stably transfected with one of KOP (show SPINT2 Antibodies), MOP (show NLN Antibodies) or DOP (show COPB2 Antibodies)
In utero exposure to opioids is associated with increased DNA methylation (show HELLS Antibodies) of ABCB1 (show ABCB1 Antibodies), CYP2D6 (show CYP2D6 Antibodies), and OPRM1 opioid-related genes in the newborn infant.
This study demonstrates that OPRM1 118A>G and the combined OPRM1/COMT (show COMT Antibodies) genotype are associated with experimental thermal pain sensitivity in a paediatric population.
This study found significant effects for rs563649, but not rs1799971 of OPRM1, the so far most frequently analyzed opioidergic SNP in pain research.
DRD2 (show DRD2 Antibodies) A2/A1, DRD3 (show DRD3 Antibodies) Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 (show GRIK1 Antibodies) rs2832407C>A are not associated with alcoholism alone or in interaction.
The OPRM1 rs1799971 A > G polymorphism is not strongly associated with alcohol-dependence. (Meta-analysis)
that promoter fragments of OPRK1 (show OPRK1 Antibodies) and OPRM1 were able to upregulate gene expression with mild cognitive impairment
Oprm1 knock-out mice lacking 6TM genetic variants failed to show morphine-induced hyperalgesia.
Findings implicate truncated Oprm1 6TM splice variants in analgesic mechanisms and suggest that they may help explain many of the subtle, but important, clinical differences among mu opioids.
The data show that somatic MORs in POMC (show POMC Antibodies) neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
C termini generated from 3' alternative splicing of the mu opioid receptor gene are pharmacologically distinct.
Double mothering normalized the abnormal response to maternal separation in Oprm1-knockout mice, in an animal model of Autism.
OPRM1, expressed by primary afferent nociceptors, initiates opiate tolerance and opioid-induced hyperalgesia development.
Study reveals dissociable Mu opioid receptors (MOR) functions across mesocorticolimbic networks. Beyond a role in reward processing, operating at the level of local ventral tegmental area neurons, MORs also moderate motivation for appetitive stimuli within forebrain circuits that drive motivated behaviors.
MOR-T394 mutation or polymorphisms could be a risk factor in developing opioid abuse and addiction and therefore be used as a new biomarker in prediction and prevention of opioid abuse and addiction
MOR epigenetic regulation requires multiple coordinated signals converging at the MOR promoter, involving mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) activation and mitogen- and stress-activated protein kinase 1 (show RPS6KA5 Antibodies).
inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling
MicroRNA miR (show MYLIP Antibodies)-212/132 cluster is actively repressing the expression of mu opioid receptor (Oprm1) by targeting a sequence in the 3' UTR (show UTS2R Antibodies) of its mRNA.
demonstrate that zfMOR exhibits a pharmacological profile similar to that of the mammalian MOR.
Coactivation of mu opioid receptors with nociceptin (show PNOC Antibodies) receptors produces synergistic antinociception.
Thisstudy adds to the growing literature showing that variation in the mu-opioid receptor gene OPRM1 is associated with social attachment and rejection.
OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors.
findings suggest a role for OPRM1 variation in the expression of attachment behavior, especially as a function of separation from the caregiver
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.
micro opioid receptor isoform hMOR-1A2
, mu opiate receptor
, mu opioid receptor hMOR-1a
, mu-type opioid receptor
, MOP receptor
, mu opioid receptor splice variant rMOR-1S
, mu opioid receptor splice variant rMOR-1Z
, opioid receptor B
, opioid receptor, mu 1
, mu opioid receptor
, mu-opioid receptor
, outer membrane protein OprM