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OPRM1 single nucleotide variants did not affect the duration of epidural fentanyl administered for early labor analgesia in nulliparous women
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association of micro Opioid Receptor polymorphism in patients of rheumatoid arthritis and its correlation with severity of disease and prevalent alleles of the OPRM1 genes
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OPRM1 A118G polymorphism (rs1799971) may be associated with a response to treatment, but not typology or predisposition toward alcoholism.
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Results demonstrate a significant association between OPRM1 and ratio between the second and fourth digits (2D:4D). Mediation analysis indicates that, in women, OPRM1 variation drives digit ratios, which are related positively to impulsivity and negatively to romantic relationship quality.
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The rs1799971 and rs1323040 polymorphisms of the OPRM1 gene and rs2032582 and rs1128503 polymorphisms of the ABCB1 gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
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MOP plays a key oncogenic function in hepatocarcinogenesis. Its overexpression is associated with poor prognosis in patients with hepatocellular carcinoma.
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cancer pain patients with GG genotype of OPRM1 need a larger dose of oxycodone that patients with AA and AG genotypes
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OPRM1 gene polymorphisms could identify the risk of gastrointestinal adverse events in prescription opioid use disorder patients
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The OPRM1 A118G AA genotype associated with elevated risk of alcohol-related hospital readmission, more readmissions, and fewer days until first readmission in male patients only. After normalizing patient 2D:4D against control 2D:4D, we found that normalized 2D:4D ratios were lower in male 118G patients than male AA patients, suggesting prenatal androgens interact with OPRM1 to influence alcohol dependence risk.
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The results indicated that genetic variation of microopioid receptor 1 (OPRM1) may contribute to interindividual differences in morphine consumption with recommendation grade A for OPRM A118G single nucleotide polymorphism (rs1799971).
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Subjects with morbid obesity and binge eating disorder (BED) had widespread reduction in OPRM1 binding compared to control subjects. However, there was no significant difference in brain OPRM1 binding between subjects with morbid obesity and BED.
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Of the 63 patients enrolled, 45 (71%) were homozygous genotype A/A (118A group), whereas 18 carried the G variants of OPRM1 (A/G or G/G) (118G group). In the Italian population participating in this study there was a different incidence of pruritus in the postcesarean period in response to intrathecal opioids related to OPRM1 gene polymorphism, but not of postoperative pain.
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Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women.
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Results from the present study suggest that, in patients with hip osteoarthritis, genetic variants in OPRM1 and OPRD1 may contribute to the pain phenotype.
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The findings of this study suggested that increased ethanol consumption in male 118GG mice may be due to increased ethanol reward, while increased drinking in female 118GG mice might be due to decreased sensitivity to the sedative/ataxic effects of ethanol.
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The results showed that, while both the 118AA and 118GG mice demonstrated robust avoidance of the heroin-paired saccharin cue following daily taste-drug pairings, only the 118AA mice suppressed intake of the heroin-paired saccharin cue when 48h elapsed between each taste-drug pairing
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There was no association between OPRM1 SNPs and oral pain sensitivity.
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This study showed that The opioid receptor mu 1 (OPRM1) rs1799971 and catechol-O-methyltransferase (COMT) rs4680 as genetic markers for placebo analgesia.
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A functional polymorphism in the mu opioid receptor OPRM1 (A118G, rs1799971) and interactive effects of maternal overcontrol have been shown to impact sympathetic nervous system activation and stress reactivity associated with the development of Anxiety in school-aged children.
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Possession of the OPRM1 minor allele, 118G and lower mother-child language style matching were both associated with greater Separation Anxiety Disorder symptoms.