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The analysis of the distribution of genotypes in CEP135 rs4865047 and NPY2R rs1902491 detected significant differences only in the single nucleotide polymorphism rs4865047 genotype between the case and control group in comparison to the reference group. No significant association was found for the NPY2R SNP rs1902491 genotype.
genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD
not detected in infantile hemanogiomas
polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis.
The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.
Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
The results of this study provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing
Data indicate modest association of the age at onset (AO) with two neuropeptide Y (NPY) promoter variations and a highly significant association with NPY receptor NPY2R promoter single nucleotide polymorphism (SNP rs2234759).
This study reviews neuropeptide Y2 receptor modulators (mainly non-peptidic antagonists) and their structure-activity relationships.
this study concludes that common genetic variation in the proximal NPY2R promoter influences transcription factor binding so as to alter gene expression in neuroendocrine cells, and consequently cardiometabolic traits in humans.
we determined the role of the C-terminus in the anterograde transport of the human neuropeptide Y receptor (hYR) type 2
Surface masking of the Y2 receptor could to a degree reflect restricted access of the large (34-36-residue) physiological agonists.
NPY2R expression in neonatal saliva is predictive of an immature feeding pattern.
The influence of beta-arrestin adaptors and endocytosis mechanisms on plasma membrane diffusion and particle brightness of GFP-tagged neuropeptide Y (NPY) receptors, was investigated.
Four genetic loci were strongly and independently associated with obesity, NPY2R, NPFFR2, MC4R, and FTO.
protocol for the preparation of fully active Y2 G protein-coupled receptor
Data present a site-directed mutagenesis study of four amino acid positions in the human Y2 receptor.
Results report on the functional reconstitution of the hY(2)R and the hY(4)R in Sf9 insect cells using the baculovirus system.
It was concluded that PYY signaling through Y2R is not required for the normal appetite-suppressing and body weight-lowering effects of Roux-en-Y gastric bypass in this global knockout mouse model.
High Npy2r expression is associated with chronic social defeat stress.
These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. The effect on visceral pain seems to be mediated by peripheral Y2 receptors.
NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Findings suggest that neuropeptide Y is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
confirms the critical role of Y2 signalling to control neuropeptide Y and associated pro-opiomelanocortin expression in the arcuate nuclei
Study shows that NPY inhibits fear learning and promotes cued extinction by reducing fear expression also via activation of presynaptic Y2 receptors on central amygdala neurons
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
an integrated neural circuit modulates growth hormone release relative to food intake; data provide essential information to address the differential roles of Y1 and Y2 receptors in regulating the release of GH under fed and fasting states
Our results showed the altered expression of NPY, Y1R and Y2R but not Y5R in hippocampus and temporal lobe cortex of tremor rat brain.
Data from knockout (KO) mice suggest roles for neuropeptide Y (NPY) and NPY2 receptors in fear acquisition/fear stimulus discrimination. Npy1r/Npy2r double KO mice display excessive recall of conditioned fear/impaired fear extinction.
NPY Y2 receptors control the level of hyperactive behavior under conditions of limited food access.
Peripheral Y2 receptor signaling is critical in the regulation of oxidative fuel selection and physical activity and protects against high-fat diet-induced obesity.
Data show that Y2R is mostly presynaptic, coexists with NPY and NPY Y1R, and suggest that Y2Rs thus have a modulatory role in mediating presynaptic neurotransmitter release.
NPY-Y2 receptor exerts a direct control over both the tonic and phasic release of dopamine
Data describe the complex interaction between Y2/Y4 receptors in control of bone mass, and suggest that the reduction in cortical bone observed in the absence of leptin is due to the anti-osteogenic effect of elevated hypothalamic NPY levels.
Data from studies in knockout mice suggest that signaling through Y2 receptor prevents development of long-term anxiety-/depression-like behaviour caused by acute immune challenge. Study includes comparison with Y4 receptor knockout mice.
Taken together, this work demonstrates the critical roles of Y2 and Y4 receptors in the regulation of body composition and energy metabolism, highlighting dual antagonism of Y2 and Y4 receptors as a potentially effective anti-obesity treatment.
PYY/PYY(3-36) potently inhibits basal and stress/serotonin/cholinergic-stimulated propulsive colonic motor function in conscious mice, likely via Y(2) receptors
data reveal an anti-osteogenic effect of Y2 receptors on hypothalamic NPY-expressing neurons on trabecular but not on cortical bone
Lower mRNA levels of neuropeptide Y receptor 1 (NPY1R) and NPY5R but not NPY or NPY2R in the central nucleus of the amygdala predicted elevated anxious temperament.
The rabbit kidney and the human CHO cell-expressed Y2 dimers are converted by agonists to monomers in vitro at a similar rate in the presence of divalent cations.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved.
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > PYY and NPY free acid.
, Y2 receptor
, neuropeptide Y receptor type 2
, neuropeptide Y receptor 2
, neuropeptide Y receptor Y2-like
, neuropeptide Y-Y2 receptor
, neuropeptide Y/peptide YY-Y2 receptor
, neuropeptide Y receptor Y2
, Neuropeptide Y receptor type 2
, neuropeptide Y Y2 receptor
, gastric Y2 receptor
, neuropeptide Y receptor type 2-like