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genetic variation in NPY (show NPY Proteins) and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD
polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis.
The C-terminal alpha-helix of Neuropeptide Y (show NPY Proteins), which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.
Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
The results of this study provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing
Data indicate modest association of the age at onset (AO) with two neuropeptide Y (NPY (show NPY Proteins)) promoter variations and a highly significant association with NPY (show NPY Proteins) receptor NPY2R promoter single nucleotide polymorphism (SNP rs2234759).
This study reviews neuropeptide Y2 receptor modulators (mainly non-peptidic antagonists) and their structure-activity relationships.
this study concludes that common genetic variation in the proximal NPY2R promoter influences transcription factor binding so as to alter gene expression in neuroendocrine cells, and consequently cardiometabolic traits in humans.
These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. The effect on visceral pain seems to be mediated by peripheral Y2 receptors.
NPY (show NPY Proteins) and agonists of Y2R and Y5R (show NPY5R Proteins) may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Findings suggest that neuropeptide Y (show NPY Proteins) is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
confirms the critical role of Y2 signalling to control neuropeptide Y (show NPY Proteins) and associated pro-opiomelanocortin (show POMC Proteins) expression in the arcuate nuclei
Study shows that NPY (show NPY Proteins) inhibits fear learning and promotes cued extinction by reducing fear expression also via activation of presynaptic Y2 receptors on central amygdala neurons
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY (show NPY Proteins) synthesis and NPY (show NPY Proteins) receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
an integrated neural circuit modulates growth hormone release relative to food intake; data provide essential information to address the differential roles of Y1 and Y2 receptors in regulating the release of GH under fed and fasting states
Our results showed the altered expression of NPY (show NPY Proteins), Y1R (show NPY1R Proteins) and Y2R but not Y5R (show NPY5R Proteins) in hippocampus and temporal lobe cortex of tremor rat brain.
Data from knockout (KO) mice suggest roles for neuropeptide Y (NPY (show NPY Proteins)) and NPY2 receptors in fear acquisition/fear stimulus discrimination. Npy1r (show NPY1R Proteins)/Npy2r double KO mice display excessive recall of conditioned fear/impaired fear extinction.
NPY (show NPY Proteins) Y2 receptors control the level of hyperactive behavior under conditions of limited food access.
Lower mRNA levels of neuropeptide Y (show NPY Proteins) receptor 1 (NPY1R (show NPY1R Proteins)) and NPY5R (show NPY5R Proteins) but not NPY (show NPY Proteins) or NPY2R in the central nucleus of the amygdala predicted elevated anxious temperament.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor (show NPY5R Proteins) subtypes are well conserved, whereas Y4 receptors are less well conserved.
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > PYY and NPY free acid.
, Y2 receptor
, neuropeptide Y receptor type 2
, neuropeptide Y receptor 2
, neuropeptide Y receptor Y2-like
, neuropeptide Y-Y2 receptor
, neuropeptide Y/peptide YY-Y2 receptor
, neuropeptide Y receptor Y2
, Neuropeptide Y receptor type 2
, neuropeptide Y Y2 receptor
, gastric Y2 receptor
, neuropeptide Y receptor type 2-like