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results provide evidence that PGI2/IP signaling suppresses the STAT6-independent pathway of allergic airway inflammation
Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir) is involved in insulin secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin.
Deletion of the I prostanoid receptor had no effect on the attenuation of atherogenesis by mPGES-1 deletion in the low-density lipoprotein receptor knockout mice.
Prostacyclin promotes the up-regulation of Nox4 in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions.
Its signaling increase cAMP concentration, which prototes sysnesis of HGF, causing angiogenesis.
an essential role of the COX-2/PGI2 receptor axis in the cardioprotection afforded by the late ischemic preconditioning
findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target
PGI2-induced PPAR delta activation accelerates blastocyst hatching in mice
For the first time these results show that activation of prostaglandin I2 receptor can attenuate damage following cerebral ischemia.
identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4(+) Th2 cells into the inflammatory site
The prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB phosphorylation.
Prostaglandin I2 receptor signaling promotes T helper cell type (Th)1 differentiation through a cyclic adenosine monophosphate (AMP)-protein kinase A pathway, thereby initiating acquired cutaneous immune responses.
The prostaglandin I(2)-IP system is essential for EPCs to accomplish their function and plays a critical role in the regulation of vascular remodeling.
Results identify the cyclooxygenase-2 gene as a target of APOE signaling, link HDL and APOE to prostacyclin receptor IP action, and describe a potential new basis for the cardioprotective effect of HDL and APOE.
results suggest that signaling through IP has antiviral effects while protecting against respiratory syncytial virus-induced illness
The -CSLC motif of the IP is a direct target for inhibition by the FTI SCH66336, and in the presence of strong farnesyltransferase inhibition, the IP does not undergo compensatory geranylgeranylation.
Baseline systolic blood pressurewas significantly lower in the IP(-/-) group than in the IP(+/+) mice.
IP plays a suppressive role in the development of pressure overload-induced cardiac hypertrophy via the inhibition of both cardiomyocyte hypertrophy and cardiac fibrosis
IP receptors play an important role in preimplantation embryo development and mediate the embryo's response to exogenous PGI(2)
The decrease in acid secretion in the damaged stomach is mediated by endogenous PGs derived from COX-1, through PGE(2)/EP3 receptors and prostacyclin/IP receptors.
these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the human prostacyclin receptor (hIP), and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms.
role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature.
Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (PTGIR) is involved in insulin secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin.
The human prostacyclin receptor gene is under the transcriptional regulation of dihydrotestosterone, where this regulation is further influenced by serum-cholesterol levels.
cPGI2 generates via its cognate cell-surface receptor IP-R, converting white adipocytes to brite adipocytes.
these findings suggest that reduced IPR expression in DM2 platelets may contribute to platelet hyperactivity in humans with type 2 diabetes.
A total of 38 non-synonymous mutations were identified within the coding region of the hIP receptor, mapping to 36 distinct residues, including several mutations previously reported to affect the signaling of the hIP receptor.
Prostaglandin I2- Prostaglandin I2 receptor signaling regulates human Th17 and Treg cell differentiation.
The present report is the first to show an association between the A984C polymorphism of the IP gene and platelet activation in Japanese subjects.
these data provide critical insights into the transcriptional regulation of the human prostacyclin receptor gene within the vasculature, including during megakaryocytic differentiation
IP receptor heteridimerization with thromboxane receptor facilitates receptor trafficking to membrane lipid rafts.
Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3-dependent
IKEPP was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP
the IP receptor was expressed in blood vessels of renal cell carcinoma specimens, but not in glomerular vessels of normal renal tissue; findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target
VDAC is the ATP conduit in the IP receptor-mediated signaling pathway in human erythrocytes.
Human prostacyclin receptor interacts with the PDZ adapter protein PDZK1; this interaction plays important role in endothelial cell migration and angiogenesis.
study identified a novel 8 residue ER export motif within the functionally important alpha-H8 of the hIP.
decreased maternal plasma levels in severe preeclamptic pregnant women
of 18 non-synonymous mutations, all with frequencies less than 2% in our study cohort, eight of the 18 had defects in binding, activation, and/or protein stability/folding
IP(R212C) exerts a dominant action on the wild-type IP and thromboxane receptor through dimerization. This likely contributes to accelerated cardiovascular disease in individuals carrying 1 copy of the variant allele.
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
, PGI2 receptor
, prostacyclin receptor
, prostaglandin I2 receptor
, prostanoid IP receptor
, prostaglandin I receptor (IP)