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prostacyclin regulates bone growth via the Epac/Rap1 pathway
cAMP binds Xepac protein enabling it to activate the Ca2 (show CA2 Antibodies)+ pathway, which is necessary to start and maintain X. laevis vitellogenin (show VTG Antibodies) uptake.
EPAC1 and EPAC2 (show RAPGEF4 Antibodies) expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability.
study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein (show AKAP13 Antibodies) 9 (AKAP9 (show AKAP9 Antibodies)).
We show that hematopoietic cell generation requires cAMP signaling through the Exchange proteins activated by cAMP (cAMP-Epac) axis..in hematopoietic progenitor and stem-like cells, cAMP induction mitigated oxidative stress, created a redox-state balance, and enhanced C-X-C chemokine receptor type 4 (CXCR4 (show CXCR4 Antibodies)) expression, benefiting the maintenance of these primitive cells
No significant association was observed between RAPGEF3 SNPs and the risk of Alzheimer's disease or neuropsychiatric inventory scores.
This review focus is on the function of Epac in the heart. Accumulating evidence has revealed that both Epac1 and Epac2 (show RAPGEF4 Antibodies) play important roles in the structure and function of the heart under physiological and pathological conditions. [review]
This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1 (show SLC9A3R1 Antibodies). Our findings identify a new CFTR (show CFTR Antibodies)-interacting protein and demonstrate that cAMP activates CFTR (show CFTR Antibodies) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1.
The contribution of EGFR (show EGFR Antibodies), EPAC, and Ca(2 (show CA2 Antibodies)+) in CDCA-induced activation of CFTR (show CFTR Antibodies)-dependent Cl(-) secretion.
Microtubule stabilization was further suggested by the finding that ascorbate increased the amount of Epac1 bound to alpha-tubulin (show TUBA4A Antibodies).
during Epac1-induced activation of mTORC1 and mTORC2 (show CRTC2 Antibodies), Epac1 may have an additional function as a scaffold protein (show HOMER1 Antibodies)
The overexpression of EPAC1 can be used as a marker to predict the outcome of patients with GC, and EPAC1 represents a potential therapeutic modality for treating gastric cancer
Arrhythmic effects of Epac-mediated ryanodine receptor (show RYR3 Antibodies) activation in Langendorff-perfused murine hearts
In retinopathy, EPAC-1 expression is decreased in a microRNA-7-mediated manner, contributing to endothelial dysfunction.
Epac1 exerts a tonic inhibition of in vivo basal microvascular permeability
In behavioral tests, Epac1-/- mice exhibited similar phenotype to those of WT mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (show CNR1 Antibodies) receptors. Among the six isoforms of phospholipase C (PLC (show PLC Antibodies); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (show PLCE1 Antibodies), PLCzeta (show PLCz1 Antibodies), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (show DHDDS Antibodies)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Data suggest that Epac1 reduces formation of the NLRP3 (show NLRP3 Antibodies) inflammasome to reduce inflammatory responses in the retinal vasculature.
Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (show LEP Antibodies) expression and secretion in white adipose tissue.
data demonstrate that endogenous PGE2, EP2 (show SPAG11A Antibodies) receptors, and EPAC are prerequisites for maximal LPS (show TLR4 Antibodies)-induced IL-33 (show IL33 Antibodies) expression and that exogenous PGE2 can amplify IL-33 (show IL33 Antibodies) production via EP2 (show SPAG11A Antibodies) and EP4 (show PTGER4 Antibodies) receptors.
Epac1 is involved in AC5 (show ADCY5 Antibodies)-mediated catecholamine stress-induced cardiac fibrosis. Epac1 is involved in AC5 (show ADCY5 Antibodies)-mediated elongation of atrial fibrillation.
Within heart mitochondria, different Epac1 microdomains control myocardial cell death.
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner
Rap guanine nucleotide exchange factor (GEF) 3
, RAP guanine-nucleotide-exchange factor 3
, exchange protein directly activated by cAMP 1
, rap guanine nucleotide exchange factor 3
, Rap1 guanine-nucleotide exchange factor
, rap guanine nucleotide exchange factor 3-like
, EPAC 1
, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
, cAMP-regulated guanine nucleotide exchange factor I
, exchange factor directly activated by cAMP 1
, cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)
, epac 1