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prostacyclin regulates bone growth via the Epac/Rap1 pathway
cAMP binds Xepac protein enabling it to activate the Ca2 (show CA2 Antibodies)+ pathway, which is necessary to start and maintain X. laevis vitellogenin (show VTG Antibodies) uptake.
Cyclic AMP (show APRT Antibodies) (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2 (show RAPGEF4 Antibodies), which exhibit different tissue distribution and is involved in GDP/GTP (show AK3 Antibodies) exchange along with activating Rap1 (show RABGEF1 Antibodies)- and Rap2 (show RAP2A Antibodies)-mediated signaling pathways.
These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma.
Authors show that blockade of cAMP signaling using MDL12330A led to an increase in PUMA (show BBC3 Antibodies) transcript levels, but not p21 (show CDKN1A Antibodies) in melanoma cells. Results suggest that transcriptional repression is one of the functions of the cAMP-Epac signaling pathway.
Results show that Epac1 binds to importin beta1 which prevents its accumulation in plasma membrane and, uncover a cAMP-independent function of Epac1 at the plasma membrane in the regulation of neurite outgrowth.
Data show that the Epac-Rap1 signaling axis is involved in triapine resistance.
This study indicates a novel role for Epac1 in PGE2-induced epithelial-to-mesenchymal transition and subsequent activation of beta-catenin (show CTNNB1 Antibodies)
EPAC1 and EPAC2 (show RAPGEF4 Antibodies) expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability.
study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein (show AKAP13 Antibodies) 9 (AKAP9 (show AKAP9 Antibodies)).
We show that hematopoietic cell generation requires cAMP signaling through the Exchange proteins activated by cAMP (cAMP-Epac) axis..in hematopoietic progenitor and stem-like cells, cAMP induction mitigated oxidative stress, created a redox-state balance, and enhanced C-X-C chemokine receptor type 4 (CXCR4 (show CXCR4 Antibodies)) expression, benefiting the maintenance of these primitive cells
No significant association was observed between RAPGEF3 SNPs and the risk of Alzheimer's disease or neuropsychiatric inventory scores.
Epac activation reduces inflammation and microvascular permeability in an acute lung injury model.
studies indicate that Epac1 plays important roles in promoting VSMC proliferation and phenotypic switch in response to vascular injury, therefore, representing a therapeutic target for vascular proliferative diseases.
These data indicate that Epac1 may be protective to the retina through inhibition of key inflammatory mediators.
Arrhythmic effects of Epac-mediated ryanodine receptor (show RYR3 Antibodies) activation in Langendorff-perfused murine hearts
In retinopathy, EPAC-1 expression is decreased in a microRNA-7-mediated manner, contributing to endothelial dysfunction.
Epac1 exerts a tonic inhibition of in vivo basal microvascular permeability
In behavioral tests, Epac1-/- mice exhibited similar phenotype to those of WT mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (show CNR1 Antibodies) receptors. Among the six isoforms of phospholipase C (PLC (show PLC Antibodies); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (show PLCE1 Antibodies), PLCzeta (show PLCz1 Antibodies), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (show DHDDS Antibodies)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Data suggest that Epac1 reduces formation of the NLRP3 (show NLRP3 Antibodies) inflammasome to reduce inflammatory responses in the retinal vasculature.
Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (show LEP Antibodies) expression and secretion in white adipose tissue.
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner
Rap guanine nucleotide exchange factor (GEF) 3
, RAP guanine-nucleotide-exchange factor 3
, exchange protein directly activated by cAMP 1
, rap guanine nucleotide exchange factor 3
, Rap1 guanine-nucleotide exchange factor
, rap guanine nucleotide exchange factor 3-like
, EPAC 1
, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
, cAMP-regulated guanine nucleotide exchange factor I
, exchange factor directly activated by cAMP 1
, cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)
, epac 1