No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human Caveolin 3 Antibodies:
anti-Mouse (Murine) Caveolin 3 Antibodies:
anti-Rat (Rattus) Caveolin 3 Antibodies:
Go to our pre-filtered search.
Human Polyclonal Caveolin 3 Primary Antibody for IHC (p), IHC - ABIN451754
Fine, Lisanti, Argani, Li: Caveolin-3 is a sensitive and specific marker for rhabdomyosarcoma. in Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2005
Human Polyclonal Caveolin 3 Primary Antibody for FACS, ICC - ABIN258384
Dınız, Eryaşar, Türe, Akçay, Ortaç, Tekgül, Akhan: A regional panorama of dysferlinopathies. in Turk patoloji dergisi 2012
Under mechanical stress the regulation of mechanoprotection by caveolae is directly coupled with the regulation of IL6/STAT3 signaling in muscle cells and that this regulation is absent in Cav3-associated dystrophic patients.
Kir2.x isoforms have a unique intracellular pattern of distribution in association with specific Cav3 domains and that critically depends on interaction with N-terminal Kir2.x Cav3-binding motifs
T78M cav-3 induces complex modifications in ion channel function that ultimately alter membrane excitability and thus generate a susceptible substrate that, in concert with other structural alterations and/or genetic mutations, may become arrhythmogenic.
Case series demonstrates that exercise intolerance, myalgia and rhabdomyolysis may be caused by CAV3 mutations and broadens phenotypic spectrum of caveolinopathies. Percussion-induced rapid muscle contractions were seen in 5 of 6 patients. A previously reported heterozygous mutation in CAV3 (p.T78M) and 3 novel variants (p.V14I, p.F41S, p.F54V) were identified. >50% reduction of caveolin-3 in 5 patients vs controls.
our study indicates that TASK-1 is functionally regulated by caveolin-3, possibly via association with each other on the cell surface. These results point out a novel mechanism in the regulation of TASK-1.
The caveolin 3 G56S variant is not a clearly pathogenic mutation, but may influence cellular functions and morphologies resulting in an increased cellular vulnerability in terms of a modifying factor.
Our results indicate that HCN4 channel function is modulated by cav-3. LQTS-associated mutations of cav-3 differentially influence pacemaker current properties indicating a pathophysiological role in clinical manifestations.
This study demonstrated that the Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.
Study characterized the secondary structure, dynamics, and topology of a lipidated full-length human Cav3 construct, demonstrated that the N-terminal domain undergoes a dramatic topological rearrangement in both micelles and vesicles that is reversibly mediated by pH
The Cav3 P104L mutation of limb girdle muscular dystrophy-1C leads to disordered glucose metabolism in muscle cells.
Data (including data from studies using recombinant proteins that lack typical in-vivo post-translational modifications such as palmitoylation) suggest Cav3 exhibits little tendency to partition into liquid-ordered domains of unilamellar vesicles.
MURC/cavin-4, especially in combination with Cav-3, may play a consistent role in the differentiation process of rhabdomyosarcoma.
This study demonstrated that cav3 mutation in stinct disorders including limb-girdle muscular dystrophy 1C, rippling muscle disease, and isolated creatine kinase elevation in Greece.
In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes.
We identified three novel sequence variations (c.183C>G, p.S61R; c.220C>A, p.R74S; c.220C>T, p.R74C) and found evidence that one was associated with hypercreatine kinase-emia
our results indicate that inhibition of Cav3 currents by 5,6-epoxyeicosatrienoic acid is an important mechanism controlling the vascular tone.
detrimental effect of Cav-3 V82I variant on cell viability may participate in determining the susceptibility to cardiac death.
The caveolin-3:p.T78M did not exhibit a long-QT syndrome phenotype.
Cav3 is an important negative regulator for cardiac late sodium cutrrent via nNOS dependent direct S-nitrosylation of SCN5A.
data show a developmental change in HCN4-Cav3 association in human embryonic stem cell-derived cardiomyocytes. Cav3 expression and its association with ionic channels likely represent a crucial step of cardiac maturation
these findings revealed a novel role of FAT10 in protection against ischemia-induced injury via stabilization of Cav-3
Pathogenic p.P104 mutation causes endoplasmic reticulum stress, impairs protein processing, ECM remodeling and sarcolemmal integrity.
Cav-3 and Smad3 may be involved in the occurrence and development of viral myocarditis.
CAV3 protein has a physiological role in glycometabolism, growth and proliferation, independent of insulin stimulation
Data show that caveolin-3 binds to low glycosylated extracellular matrix metalloproteinase inducer (LG-EMMPRIN) in cardiac cells and in the hearts of healthy mice.
Cav-3 overexpressing mice have changes in ECG intervals, heart rates, and cardiac ion channel expression
Loss of CAV3 interferes with downstream insulin signaling and lipid uptake and increases susceptibility to palmitate-induced insulin resistance.
eNOS, caveolin-3, and connexin-43 were detected in subsarcolemmal mitochondria
Data show increased expression of T-type Ca(2+) current and association of protein kinase C alpha (PKCalpha) with caveolin-3 (Cav-3)was disrupted in the hypertrophic ventricular myocyte.
Cardioprotection in myocardial infarction is abolished in caveolin-3 knockout mice.
The lithogenic diet was associated with significantly lower CAV3 in the liver and lower CAV3 and CCKAR in the gallbladder compared with the control mice.
Cav-3 may be a novel participant in B-cell expression, T-cell cytokine production and activation of inflammation
Cav3 protein can modify integrin function and mechanotransduction in the cardiomyocyte and intact heart
Deinactivation of Cav3 channels increases T-type Ca(2+) influx and increases feedback inhibition in olfactory bulb.
Data reveal the membrane cholesterol dependence of normoxic myocardial and coronary function, I/R tolerance, and morphine-mediated cardioprotection in murine hearts (all declining with cholesterol depletion).
The Cav-1 and Cav-3 knockout mice exhibited enhanced lesion volume and cytokine/chemokine production after Traumatic brain injury.
Cav-3 has a pivotal role in defending cardiomyocytes against the TNF pro-apoptotic action and alpha-linoleic acid has the capacity to regulate this mechanism preventing cardiac degenerative diseases.
the distribution of ryanodine receptors (RyRs) and caveolin-3 (CAV3) in mouse ventricular myocytes
Palmitate diet-induced loss of cardiac caveolin-3 constitutes a novel mechanism for lipid-induced contractile dysfunction.
Cav3 is involved in muscle development and is required for correct intracellular organization and myoblast fusion.
cloned and characterized caveolin-3 from porcine muscle; caveolin-3 was expressed specifically in skeletal muscle & heart; first evidence that caveolin-3 has a certain regulated expression pattern during the prenatal period of skeletal muscle development
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
, calveolin 3
, caveolin 3