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Human CRP Protein expressed in HEK-293 Cells - ABIN6253726
Meyer, Ueland: Targeted quantification of C-reactive protein and cystatin c and its variants by immuno-MALDI-MS. in Analytical chemistry 2014
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dissociation of pCRP to mCRP could be rapidly induced by ROS from copper- hydrogen peroxide system in dependence on mildly acidic stress regardless of a redox-balanced microenvironment.
Higher preoperative CRP levels have a robust prognostic impact on recurrence-free survival in differentiated thyroid carcinoma patients. In addition, higher preoperative CRP levels were associated with age >/= 55 y and T3 + T4.
Compared with fentanyl combined anesthesia, the remifentanil combined anesthesia can significantly reduce serum levels of cytokines IL-8, IL-6, CRP, TNF- α and oxidative stress level, and is, therefore, more secure for patients undergoing laparoscopic surgery for colon cancer.
Serum levels of C-reactive protein are related to heart failure and left ventricular hypertrophy in hemodialysis patients.
Simultaneous positivity of serum IL-6 either with synovial IL-6 or synovial CRP almost excludes false negative detection of prosthetic joint infection at the site of interest.
Concurrent elevation of preoperative SCC-Ag, CYFRA 21-1 and CRP serum levels can be correlated with worse survival rates in oral cavity squamous cell carcinoma.
CRP6w may serve as a prognostic biomarker in patients with resected non-small cell lung cancer.
In rheumatoid arthritis patients, an inverse U-shaped relationship was found between C-reactive protein and systolic blood pressure.
Higher levels of myocardial infarction-triggered acute stress disorder symptoms associate with a greater inflammatory response and elevated circulating C-reactive protein levels in patients with acute myocardial infarction independently of important covariates.
In summary, diabetes was associated with decreased pulmonary volumes in a large sample of middle-aged adults in northern France. Our results showed that hs-CRP mediated a small part of this association. The mechanisms involved in the association between diabetes and pulmonary volumes mostly remain to be understood.
This study disclosed no difference in CRP levels per se between exudative AMD patients with control group. However, higher levels of CRP in the presence of C allele of Y402H might confer more risk for the development of exudative AMD.
Patients with elevated C-reactive protein (hsCRP) and homocysteine (HCY) levels had a 2.50-fold increased risk of developing metabolic syndrome (MetS).
in pregnant women, serum levels of CRP can early recognize subjects at higher risk for maternal and neonatal complications.
CRP rs1205 is associated with fasting glucose level.
Among participants with obesity-induced higher hsCRP levels, a higher frequency of vegetable/legume intake was inversely related to hsCRP.
this study showed that HBV and HCV infections are associated with CRP plasma level and chronic liver inflammation. Research may determine if these findings may be interpreted as a potential escape of the virus from the immune response, and studies involving other components of the immune response as well as the effects of antiviral and antifibrotic therapies that can restore liver function and CRP expression are needed.
High-sensitivity C-reactive protein levels (and HMGB1) are significantly higher in Parkinson's disease patients compared to controls.
In obese females, hs-CRP levels might be a promising biomarker of visceral fat amount and dysfunction, in addition to predict the effectiveness of bariatric surgery in terms of loss of visceral fat area one-year after surgery.
C-reactive protein <100 mg/L is associated with a lower risk of intra-abdominal complication and readmission rates after colorectal resection.
Patients with elevated levels of C-reactive protein had worse cognitive and depressive symptoms at one year follow-up compared to patients with lower levels of C-reactive protein.
Enhanced external counterpulsation decreased C-reactive protein and increased flow-mediated dilation in hypercholesterolemia.
serum C-reactive protein correlates with macrophage accumulation and coronary artery disease in hypercholesterolemic pigs
CRP inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H oxidase via p38 kinase activation.
The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS. (postweaning multisystemic wasting syndrome)
These data suggest that CRP might play a pathogenic role in the development of myointimal hyperplasia in polytetrafluoroethylene grafts.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP
CRP stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2) synthesis.
Data show that during posttranplant obliterative bronchiolitis development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.
this study shows that C-reactive protein impairs dendritic cell development, maturation, and function
CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling.
FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex.
These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways.
these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP.
CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway.
mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia.
Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells
These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways.
Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.
the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo
CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors.
Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
The interactions of CRP and the BBB are a two-phase process, with increased paracellular permeability at a high dose that enables its entry into the CNS and serves to induce reactive gliosis and impair CNS function.
Radiation combined injury-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival.
In mice with photochemically induced thrombosis, acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma.
CRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice.
Which processes in glucose homeostasis are altered by CRP? Data suggest that CRP attenuates insulin-induced skeletal muscle blood flow; CRP contributes to insulin resistance via IgG receptor IIB-mediated inhibition of glucose delivery to muscle.
CRP is not only a biomarker, but also a mediator in DKD.
data show, for the first time, a significant increase of c-reactive protein (CRP) in the blood of calves 1 d after colostrum intake.
Rabbit CRP acute-phase system binds phosphocholine and phosphoethanolamine.
IL-6 augments mechanical strain-induced CRP synthesis in vessels via the stretch-activated channel-NF-kappaB pathway.
CRP antagonism of eNOS is mediated by coupling of FcgammaRI to FcgammaRIIB by Src kinase and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo.
Metformin attenuated the progression of aortic atherosclerosis via down-regulation of serum C-reactive protein.
During abdominal aortic aneurysm formation, increased serum hsCRP levels derive from aneurysmal arteries with degenerating elastic lamina.
crystal of C-reactive protein diffracted to 2.3 A resolution and belonged to space group R3, with unit-cell parameters a = b = 114.7, c = 61.0 A
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
, pentraxin 1
, C-reactive protein, petaxin related
, C-reactive protein member of the pentraxin family
, C-reactive protein, member of the pentraxin family
, amyloid P component, serum
, serum amyloid P component
, pentraxin-related C-reactive protein
, uncharacterized protein LOC751795