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Human CRP Protein expressed in HEK-293 Cells - ABIN6253726
Meyer, Ueland: Targeted quantification of C-reactive protein and cystatin c and its variants by immuno-MALDI-MS. in Analytical chemistry 2014
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Cumulative incidence of metabolic syndrome was significantly increased according to hs-CRP tertile level.
Patients undergoing haemodialysis with a lower albumin level and higher CRP level have an increased risk of peripheral arterial disease.
this study in a middle-aged and elderly Japanese population showed a positive association between plasma CRP level and colorectal adenoma, notably in larger and multiple adenomas.
Sarcopenia is associated with systemic inflammatory response such as high CRP/Alb ratio, while the latter is an independent prognostic marker in patients with esophageal cancer
gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production.
Combinative index (arterial lactate, NT-proBNP and CRP) could serve as a valuable predictor for the 28-day mortality rate in patients with sepsis.
CRP rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing Systemic Lupus erythematosus
The study showed that higher CRP and lower T3 levels were associated with stroke severity on admission. Functional outcome is likely secondary to stroke severity but functional outcome at discharge was associated with higher CRP levels.
These findings reveal that the CRP- and PTX3-binding characteristics of FHL-1 differ from those of FH, likely underpinning independent immune regulatory functions in the context of the human retina.
Short-term changes in daily movement behaviour can affect salivary CRP, a marker of systemic inflammation.
M1 macrophages were characterized by elevated CRP mRNA expression (by 67%), CRP protein levels (by 108%), and upregulation of NFkappaB activation
Levels of CRP and PCT in CSF did not present greater accuracy in differentiating bacterial from viral meningitis compared to serum levels.
elevated serum C-reactive protein (CRP) is a well-known proxy for infections/immune abnormalities. Our results show elevated C-reactive protein levels to be associated with an increase in risk for schizophrenia.
High CRP expression is associated with Nonalcoholic fatty liver disease.
High C-reactive protein expression is associated with impaired glucose tolerance.
Findings indicate that childhood infections do not have an independent, lasting effect on circulating inflammatory marker levels subsequently in childhood; however, elevated inflammatory markers may be harmful for intellectual development/function.
maternal serum level has predictive value for chorioamnionitis
serum level elevated in preterm labor leading to preterm birth
Among healthy women attempting pregnancy after one or two pregnancy losses, elevated C-reactive protein is associated with reduced fecundability.
Suggest a close association between CRP and metabolic syndrome, while the association between the dietary inflammatory index and MetS was limited.
Enhanced external counterpulsation decreased C-reactive protein and increased flow-mediated dilation in hypercholesterolemia.
serum C-reactive protein correlates with macrophage accumulation and coronary artery disease in hypercholesterolemic pigs
CRP inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H oxidase via p38 kinase activation.
The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS. (postweaning multisystemic wasting syndrome)
These data suggest that CRP might play a pathogenic role in the development of myointimal hyperplasia in polytetrafluoroethylene grafts.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP
CRP stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2) synthesis.
Data show that during posttranplant obliterative bronchiolitis development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.
CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling.
FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex.
These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways.
these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP.
CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway.
mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia.
Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells
These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways.
Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.
the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo
CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors.
Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
The interactions of CRP and the BBB are a two-phase process, with increased paracellular permeability at a high dose that enables its entry into the CNS and serves to induce reactive gliosis and impair CNS function.
Radiation combined injury-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival.
In mice with photochemically induced thrombosis, acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma.
CRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice.
Which processes in glucose homeostasis are altered by CRP? Data suggest that CRP attenuates insulin-induced skeletal muscle blood flow; CRP contributes to insulin resistance via IgG receptor IIB-mediated inhibition of glucose delivery to muscle.
CRP is not only a biomarker, but also a mediator in DKD.
C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice.
data show, for the first time, a significant increase of c-reactive protein (CRP) in the blood of calves 1 d after colostrum intake.
Rabbit CRP acute-phase system binds phosphocholine and phosphoethanolamine.
IL-6 augments mechanical strain-induced CRP synthesis in vessels via the stretch-activated channel-NF-kappaB pathway.
CRP antagonism of eNOS is mediated by coupling of FcgammaRI to FcgammaRIIB by Src kinase and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo.
Metformin attenuated the progression of aortic atherosclerosis via down-regulation of serum C-reactive protein.
During abdominal aortic aneurysm formation, increased serum hsCRP levels derive from aneurysmal arteries with degenerating elastic lamina.
crystal of C-reactive protein diffracted to 2.3 A resolution and belonged to space group R3, with unit-cell parameters a = b = 114.7, c = 61.0 A
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
, pentraxin 1
, C-reactive protein, petaxin related
, C-reactive protein member of the pentraxin family
, C-reactive protein, member of the pentraxin family
, amyloid P component, serum
, serum amyloid P component
, pentraxin-related C-reactive protein
, uncharacterized protein LOC751795